Pain Thera up 10%  [Aug 6, 12]

Pain Therapeutics up 11% [Oct 10, 11]

Pain Thera up 15% [Aug 9, 11]

Pain Thera down 26% [Jun 27, 11]

Pain Thera down 43% [Jun 24, 11]  delayed in gaining U.S. approval for a second time of a new type of painkiller designed to curb drug abuse [Bloomberg, Jun 24, 11]

Pain Therapeutics up 13% [Mar 30, 11]

Pain Therapeutics up 10% [Feb 11, 11]

Pain Therapeutics  down 17% [Jul 7, 09] after its partner for painkiller Remoxy -- King Pharmaceuticals -- said it plans to resubmit a new drug application later than investors had expected. [Wall Street Journal, Jul 8]

Pain Thera down 10% [Mar 5, 09]

Pain Thera up 20% [Mar 3, 09]

Pain Thera down 26% [Mar 2, 09]

Pain Therapeutics down 21% [Dec 11, 08]

An FDA panel on Thursday gave Pain Therapeutics’s tamper-free pain pill mixed reviews. At least 10 members of the Food and Drug Administration panel said Remoxy, the drug developed by Pain Therapeutics and licensed by King Therapeutics Inc., was less likely to be abused than painkillers currently on the market, according to the news agency Reuters.  But eight members said Pain Therapeutics didn’t show that the long-acting, tamper-proof version of the $2 billion painkiller oxycodone would prevent abuse.  [San Francisco Business Times, Nov 13, 08]

Pain Thera  up 11% [Oct 16, 08]

Pain Therapeutics up 12% [Sep 18, 08]

<="" a="">Palmer Labs (Durham, NC)

A giant nonprofit and a technology startup in the Triangle each snagged a slice of a $78 million federal stimulus grant to promote biofuels research. Both grant recipients are hiring engineers, project managers and other scientists for the research efforts. ... Palmer Labs (Durham, NC; no SBIR), 18-month-old, nearly $1.5million .. RTI International $750,000 to study new ways of cooking wood waste [John Murawski, Raleigh News & Observer, Jan 15, 10] Love stimulus? Remember that somebody has to pay for it, and the government has no money of its own.

<="" a="">Paloma Pharmaceuticals (Jamaica Plain, MA)

Paloma Pharmaceuticals  (Jamaica Plain, MA; no SBIR) has pulled in $500,000 in a first tranche of a planned $2 million securities offering, according to a regulatory filing. [Mass High Tech, Sep 4, 09]

<="" a="">Panacos Pharmaceuticals

Panacos Pharmaceuticals (Gaithersburg, MA; $3M SBIR) has announced a number of restructuring efforts, including layoffs of seven employees, the closing of the company’s Gaithersburg, Md., facility and the retainment of a financial advisor for the purpose of exploring a possible sale of the company or of its HIV development efforts.  [Mass High Tech, Feb 24, 09]

Panacos Pharmaceuticals said it has sold the rights and assets of bevirimat, a potential HIV drug, for $7 million.  The buyer is another biotech firm, Myriad Pharmaceuticals  of Salt Lake City, Panacos said. [Boston Globe, Jan 21, 09]

Panacos Pharmaceuticals (Watertown, MA; $4.5M SBIR) has laid off 18 employees, about 55 percent of its staff, and has announced that the company’s strategic considerations include financing, partnering or selling the company or its assets, Panacos officials said.   ....  In September, Panacos reported a quarterly loss of $8.2 million on total quarterly revenue of $20,000 [Mass High Tech, Dec 12, 08]

Panacos Pharmaceuticals (Gaithersburg, MD; $4M SBIR) reports it has completed negotiations to sever ties with its former partner Hercules Technology Growth Capital Inc. VC firm Hercules had on Nov. 19 accused Panacos of defaulting on a loan agreement signed in June 2007.  [Mass High Tech, Nov 24, 08]

Panacos Pharmaceuticals(Watertown, MA; $5+M SBIR) has been warned by NASDAQ for being below the buck. [Mass High Tech, Feb 1, 08]

<="" a="">Panomics (Fremont, CA)

Affymetrix agreed to buy Panomics (Fremont, CA; $2.3M SBIR) for $73 million in cash. -... Panomics makes products for genetic, protein and cellular analysis. [San Francisco Business Times, Nov 11, 08]

<="" a="">Paper Battery (Troy, NY)

<="" a="">Paradigm Sensors (Milwaukee, WI)

Paradigm Sensors (Milwaukee, WI; no SBIR) will begin production of biodiesel testing devices this year from a new home inside a business incubator ... start-up firm hopes to hire more than 25 people in the coming year as it starts manufacturing handheld devices that analyze biodiesel to ensure product quality ...  will soon close its first round of venture-capital funding after a $200,000 investment announced Tuesday by the Wisconsin Housing and Economic Development Authority.  [Thomas Content, Milwaukee Journal-Sentinel, Apr 3, 08]

<="" a="">Paragon Dynamics (Aurora, CO)

<="" a="">Paragonix Technologies (Cambridge, MA)

<="" a="">Parasol Therapeutics (Cambridge,MA)

biotech startup Visterra Inc., formerly known as Parasol Therapeutics, (Cambridge, MA; no SBIR) has landed $6 million in its first round of funding ... develops technology to “interrogate how pathogens interact with human cells,” which is used to develop diagnostics, vaccines and therapeutics   [Mass High Tech, Jul 12, 10]

<="" a="">Paratek Pharmaceuticals (Boston, MA)

Paratek Pharmaceuticals (Boston, MA; $3.8M SBIR)  signed a worldwide license and commercialization agreement with Novartis, in which Paratek stands to receive up to $485 million in milestone and upfront payments. The agreement centers around Paratek’s antibiotic PTK 0796, currently in Phase 3 clinical trials.  [Mass High Tech, Oct 8, 09]

Paratek Pharmaceuticals (Boston, MA; $3.8M SBIR) closed the $22M first tranche of a $40M private financing to be used to push development of its broad-spectrum antibiotics.  [Mass High Tech, Oct 25]

<="" a="">Parion Sciences (Durham, NC)

Parion Sciences (Durham, NC; $1.8M SBIR), working on treatments for pulmonary diseases, received a biodefense grant from the National Institutes of Health worth about $850,000. ... to continue testing of its most advanced experimental medicine to prevent radiation-induced lung injuries after a nuclear incident.  .... founded in 2001 and employs about 10. Its research into diseases that result from a failure of the body's mucosal defenses is based on technology developed at UNC-Chapel Hill.   [Sabine Vollmer, Raleigh News & Observer, Dec 17, 08]

Parion Sciences (Durham, NC; $1.8M SBIR)  has signed a $25 million deal with a Korean company to test an experimental medicine. [Raleigh News & Observer, Oct 29, 08]

<="" a="">Passport Systems (N Billerica, MA)

<="" a="">Pasteuria Bioscience (Alachua; FL)

Pasteuria Bioscience, (Alachua; FL; one SBIR) a venture-backed biopesticide company focusing on the development and commercialization of a platform of natural products for the control of nematodes in agriculture, received the Ag Innovation Showcase “2010 High Yield Business Award.”  [LARTA Vox, Jul 13, 10]

<="" a="">Pathfinder (Cambridge, MA)

Pathfinder (Cambridge, MA; no SBIR) cell-based therapeutics firm, and New Jersey biomaterials firm SyntheMed (no SBIR) have merged, the two companies announced   [Mass High Tech, Dec 23, 10]

<="" a=""> PathoGenetix (Woburn, MA)

<="" a="">PatientWise (Middleton, WI)

  Six young Wisconsin bioscience companies have been chosen by the state's biotech trade organization as emerging companies with good growth potential.  The companies have all transitioned successfully out of research and development and are developing commercial products, said Bryan Renk, executive director of BioForward. .... : Fused Innocation  (Neenah; WI) VibeTech (Sheboygan, WI); Somna Therapeutics (Germantown, WI); PatientWise  (Middleton, WI); NanoOncology, a subsidiary of Peptimed (Madison, WI); PharmaSeek Financial Services (Middleton, WI).  [Kathleen Gallagher, Milwaukee Journal Sentinel, Aug 30, 12]  None had SBIR.

<="" a=""> Patton Medical Devices (Austin TX)

Patton Medical Devices (Austin TX; no SBIR) raised $15M to step up the national launch of its first product, a "port" through which diabetics inject insulin. ... the company's first [money]  from institutional investors ... has raised about $12M from other investors since its founding in 2004 [Austin American-Statesman, Oct 18]

<="" a="">Patton Surgical (Austin TX)

Patton Surgical (Austin, TX; no SBIR) has received $3 million from the Texas Emerging Technology Fund to commercialize its devices, which are used in minimally invasive surgery. Founded in 2002, Patton has developed several devices, including a trocar with a shielded cutting tip. The trocar is used to insert medical instruments into a patient's abdominal cavity during what's known as laparoscopic surgery. [Austin American-Statesman, Oct 23, 09]

<="" a="">Pavilion Technologies (Austin TX)

Pavilion Technologies (Austin   TX; $1.5M SBIR), independent software development, has agreed to be acquired by Rockwell Automation  [Austin American-Statesman, Oct 31]  SBIR advocates often plead that SBIR should help companies remain independent. Nonsense, that is just using taxpayer funds to support companies in the life-style to which they would like to be accustomed.

<="" a="">Pax Streamline (San Rafael, CA)

ARPA-E winners in San Francisco Bay area: Envia Systems (Hayward); NanOasis Technologies (Richmond); Pax Streamline, (San Rafael); and Stanford University. None had SBIR. official list of winners

<="" a="">PaxVax (San Diego, CA)

PaxVax, (San Diego, CA; no SBIR) startup backed by Seattle’s Ignition Capital, has raised $2 million of a planned $6 million investment round, according to a document filed with the [SEC]. ... founded in early 2007 to develop new oral vaccine technology based on a common cold virus called the adenovirus.  [signonSanDiego, Nov 9, 09]

<="" a="">PDL BioPharma

PDL BioPharma (no SBIR) fell 32% [Mar 5, 08]. The biotechnology company abandoned plans to sell itself and said it will cut an additional 250 jobs in an effort to reduce costs. [Wall Street Journal, Mar 6]

<="" a="">Pearl Therapeutics

Respiratory disease business Pearl Therapeutics (Redwood City, CA; no SBIR) raised $15 million in loans that will be converted to equity in its next round of venture funding. [SEF Brown, San Francisco Business Times, Feb 2, 10]

[VC] firm Clarus Venures has invested in $18 M dollar financing of Pearl Therapeutics (no SBIR), a California-based biopharmaceutical company developing products for major respiratory diseases. ..... Pearl, founded in 2006, has raised $36 M of VC and other funding to date.  Nektar Therapeutics (no SBIR) has licensed advanced particle technology to Pearl, and the company it is using to develop technology that will give patients and their health care providers a choice of formulations and dosage strengths of respiratory treatments.  [Mass High Tech, Jul 7, 08]

<="" a="">Pellion Tech

Using the computational tools developed by his materials genome project, Pellion, a startup (Cambridge, MA; no SBIR), that he cofounded in 2009, has identified new cathodes for a magnesium-based battery. If it works, Ceder says, the batteries could have double or triple the energy density of today's lithium-ion batteries.  [David Rotman, Technology Review, J/F12]

ARPA-E Awards. The administration announced $106M in ARPA-E stimulus awards. Small biz winners:  Ginkgo BioWorks (Boston, MA; one SBIR) $6M primary;  OPX Biotech (no SBIR) $6M primary; Logos Tech (Arlington, VA; $2M SBIR) secondary; Sion Power (Tucson, AZ; $250K SBIR) $5M primary; ReVolt Tech (no SBIR) $5M primary; PolyPlus Battery (Berkeley, CA; one SBIR) $5M; Pellion Tech (no SBIR) $3.2M primary; A123 Systems  secondary, twice;  Planar Energy Devices (no SBIR) $4M; Maxpower (Harleysville, PA; $9M SBIR) secondary; NanoLab (Newton, MA; $5M SBIR) secondary; Codexis (no SBIR) $4.6M; Nexant (no SBIR) secondary.

Peninsula Pharmaceuticals

<="" a="">Peptimmune (Cambridge, MA)

Biotechnology companies in the United States are raising less cash than they have in a decade, in part because of the global economic crisis. The reductions have led to bankruptcies and threaten development of drugs based on biomedical breakthroughs. ... Twenty-five percent of the 370 public U.S. biotechnology companies have less than six months of cash, according to data compiled by the Biotechnology Industry Organization, a trade group in Washington. .... Among others, Peptimmune (Cambridge, MA; one SBIR), a 6-year-old firm, said it is struggling to pay for clinical trials of its multiple sclerosis drug. ... cut its staff more than half, to 22 people; moved to smaller offices to conserve the $6.5 million it has on hand; and is delaying research on drugs for Alzheimer's disease and Parkinson's disease, chief executive Thomas Mathers said. ....  On Nov. 10, MicroIslet (San Diego, CA;  $1.8M SBIR) developer of diabetes treatments, and Accentia BioPharmaceuticals (Tampa, FL; no SBIR) sought bankruptcy protection to reorganize, each citing an inability to raise money.   [David Olmos and Rob Waters, Bloomberg News, Dec 1, 08]

Peptimmune (Cambridge, MA; one SBIR) reports it has landed $8.9 million in a second close of a Series D preferred stock offering.  [Mass High Tech, Jul 17, 08]

Peptimmune (Cambridge, MA; one SBIR a decade ago) closed on an $8.2 M first tranche of a Series D funding ... to advance clinical development of Peptimmune's multiple sclerosis treatment, PI-2301 [Mass High Tech, Jan 17]

<="" a="">Perceptive Sciences (Austin, TX)

They're trained to know when you're fooling yourself, and by identifying that in their subjects they can help clients get better feedback to develop better products..... Perceptive Sciences (Austin, TX; one SBIR)  with an academic approach to product testing, market research and user experience. ... About a third of Perceptive's work focuses on Web sites, a third on software and a third on gadgets. [Dan Zehr, Austin American Statesman, Mar 3]

<="" a="">PercipEnz Technologies (Madison WI)

Three [Wisconsin] angel investment groups have banded together to put more than $1 M into a Madison software company [PercipEnz Technologies; $1.6M SBIR]  aiming to dramatically expand its clinical data management business. This is the first time several of the groups involved did their due diligence and negotiated terms together, "and that bodes well for bigger deals in Wisconsin," said Charles Goff, general partner of Appleton-based NEW Capital Fund.  [Kathleen Gallagher, Milwaukee Journal-Sentinel, Aug 22]

<="" a="">Permeon Biologics (Cambridge, MA)

 biotech startup Permeon Biologics (Cambridge, MA; no SBIR) has taken in $2.5 million in an equity and debt financing round ....  looking to develop therapies based on the discovery of a class of proteins that will allow protein-based therapies otherwise too complex to finally get inside a cell wall. The company was founded by Harvard University professor and Howard Hughes Medical Institute investigator David R. Liu, also the founder of Ensemble Therapeutics (no SBIR).  [Rodney Brown, Mass High Tech, Dec 30, 11]

<="" a="">Perscitus Biosciences (Madison WI)

The Wisconsin Department of Commerce has qualified two biotech companies to receive investor tax credits, the agency said Thursday. Perscitus Biosciences LLC, Madison, is developing a molecule that has shown an ability to protect healthy human cells against the harmful effects of chemotherapy and radiation. HTSS LLC, Milwaukee, is developing a technology that analyzes muscle activity to help reduce injuries during exercise regimens. Certain investors in both companies are now eligible to claim tax credits under legislation known as Act 255. [Milwaukee Journal-Sentinel, Jun 27]  No SBIR.

Persimmon Technologies (Wakefield, MA)

Persimmon Technologies (Wakefield, MA; no SBIR, founded 2010) which provides direct drive vacuum robotics, has received $2 million in equity financing, according the federal documents. ...  [company's] website says it is the developer, manufacturer, and distributor of atmospheric and vacuum robotics, vacuum modules, and automation systems for a range of industries, including semiconductor, data storage, LED, OLED, solar and flat panel display equipment markets. Its goal is to be the largest vacuum robotics company serving the semiconductor, LED and solar markets by 2020.  [Don Seiffert, Mass High Tech, Mar 21, 12]

<="" a=""> PersonalBee

Technorati agreed to acquire fledgling startup Personal Bee [which] developed a service for people to collect and publish news, information, and entertainment. [RedHerring.com, Apr 13]

<="" a="">Pervasis Therapeutics (Cambridge, MA)

Pervasis Therapeutics (Cambridge, MA; no SBIR) raised $10 million out of a $17 million third round of financing. ... focuses on creating cell-based compounds and devices. It is also exploring technology in non-vascular applications, such as bone and joint repair, wound healing and inflammation.  [Julie Donnelly, Mass High Tech, Sep 16, 09]

Pervasis Therapeutics (Cambridge, MA; no SBIR) secured $9.75M in additional financing. ...focuses on regenerative cell-based therapies and devices [Boston Globe, Jan 16]

Pervasis Therapeutics (Cambridge, MA; no SBIR), developer of cell-based therapies and devices, reports it has nabbed a $9.8M tranche of Series B financing. .. founded 2004 [Mass High Tech, Jan 15]

<="" a="">Pervasive (San Diego, CA)

a new semiconductor startup, courtesy of venture funding from the Bay Area.  Pervasive, (San Diego, CA; no SBIR) a fabless semiconductor design company that is focused on smart grid applications, raised $6 million from investors, according to a recent filing with securities regulators.  [Bruce Bigelow, signonsandiego.com, Jun 17, 10]

<="" a="">Pfenex

Elevation Pharmaceuticals (San Diego, CA; no SBIR, founded 2008) startup developing aerosol-based treatments for respiratory diseases, said it has raised a tranched $30 million in Series A venture funding. It’s a sizable round for the [San Diego] life sciences community, but other recent fundings have come close. Last month, VentiRx (no SBIR) raised $25 million, Pfenex (no SBIR) got $24 million, and Zogenix (no SBIR)  got $20 million.  [Bruce Bigelow, signonsandiego.com, Mar 8, 10]

<="" a=""> Pharmacyclics

Gilead announced a roughly $10.4 billion deal to buy Pharmasset  (Princeton, NJ; $2M SBIR 2000-2003 in Georgia),[up 85%] a company that doesn’t yet have meaningful revenue but is developing treatments for hepatitis C.[Shira Ovida, Wall Street Journal, Nov 21. 11]  HHS has another big econonmic SBIR story.  Would that the other agenices could be so smart in picking techologies and companies with a future.

Pharmasset  down 12% [Nov 4, 11]

Pharmasset up 15% [Aug 9, 11]

Pharmasset up 10% [Jun 8, 11]  on encouraging clinical data, it plans to test its hepatitis C treatment PSI-197 as a stand-alone therapy. Pharmasset is currently testing PSI-197 in combination with peginterferon and ribavirin, two standard treatments for the chronic liver disease. [MarketWatch, Jun 8]

Pharmasset  up 12% [Apr 5, 11]

Pharmasset up 10% [Mar 31, 11]

Pharmasset up 24%  [Mar 7, 11]

Pharmasset  up 10% [Mar 16, 10]

Pharmasset  down 10% [Apr 30, 09]

Pharmasset  up 11% [Apr 29, 09]

Pharmasset  down 10% [Apr 20, 09]  stopped development of Clevudine for hepatitis B in the wake of side effects in long-term users in South Korea, where it already is sold. [Wall Street Journal, Apr 21]

Pharmasset  up 10% [Apr 8, 09]

Pharmasset  up 11% [Mar 26, 09]

Pharmasset up 12% [Mar 17, 09]

Pharmasset  up 14% [Mar 23, 09]

Pharmasset up 12% [Mar 12, 09]

Pharmasset up 15% [Mar 3, 09]

Pharmasset down 19% [Feb 25, 09]

Pharmasset up 15% [Oct 16, 08]

Pharmasset up 15% [Oct 14, 08]

Pharmasset up 26% [Oct 13, 08]

Pharmasset down 12% [Oct 10, 08]

Pharmasset up 10% [Mar 13, 08]

Pharmasset  up 17% [Jan 16, 08]

Pharmasset up 12%. [Jan 15, 08]

Pharmasset up 33% [Jan 8, 08] after the company announced positive data from a short-term early stage study on its hepatitis C candidate, R7128

Pharmasset rose 14% after saying it will receive a $7.5M payment from Roche for a collaboration on hepatitis C treatment research

Pharmasset which IPO'd Apr 27,07 is holding its price. 14 HHS SBIR Phase 1s over $100K.

<="" a="">PhaseBio Pharmaceuticals (Morrisville, NC)

PhaseBio Pharmaceuticals (Morrisville, NC; no SBIR)  has raised about $8 million to date in two rounds of financing  [Triangle Business Journal, Nov 13, 09]

<="" a="">Phase Bioscience (Durham NC)

PhaseBio Pharmaceuticals (Durham, NC; no SBIR) raised $25 million in a series B round of financing, the company announced ...  developing therapies based on its proprietary technology with proteins that can be used to enhance the delivery of therapeutic drugs. [Triangle Business Journal, Jan 7, 10]

Phase Bioscience (Durham NC: $200K SBIR) raised $6.6M in its most recent round of financing. [Raleigh News&Observer, Oct 25]

<="" a="">Phoenix Nuclear Labs (Monona, WI)

<="" a=""> Phoenix Science (Chelmsford, MA)

Phoenix Science & Technology (Chelmsford MA) got a $15M Phase III Navy SBIR for more development of pulsed light and acoustic devices for for ultraviolet water treatment and for paint stripping of naval vessels. [Mass High Tech, Aug 26]  Navy mainline takes advantage of sole-source rules for SBIR awardees to ease its contract administration. It means juicy contracts for the good (Navy likes them) companies. The one downside to that policy is that Navy will favor companies ready for large contracts for Phase 1 and 2.  Phoenix has at at least $3.5M of Navy SBIR since 1995

<="" a=""> Phononic Devices (Raleigh, NC)

Pluromed (Woburn, MA; $1.5M SBIR) said the (FDA) has approved its LeGoo surgical gel to temporarily stop blood flow, and that it plans to expand its staff and manufacturing space over the next year. ... already has been selling the gel for a couple years in Europe, where it has the CE Mark and where it has been used in more than 1,000 surgical procedures including beating heart surgery (coronary artery bypass without the use of a heart-lung machine), bypass of the leg (in patients treated for peripheral vascular disease), and microvascular reconstruction.  [Lori Valigra, Mass High Tech, Oct 7, 11]

Pluromed (Woburn, MA; $1.5M SBIR) medical device company, has raised $1.1 million of a planned $3.9 million funding round, according to federal documents. With a total of $7.25 million raised over three previous rounds, Pluromed has now taken in almost $8.5 million in funding, federal documents showed.  ...  Founded in 2003, Pluromed was one of the first seven recipients the Accelerator Program loans, directed by the Massachusetts Life Sciences Center [Mass High Tech, Apr 23]

Pluromed (Woburn, MA; one SBIR) said it has entered into an alliance with Boston Scientific Corp., the large Natick-based medical device company, to distribute one of its products.  ... focused on the use of gel plugs in medical procedures; its products are used in cardiac, vascular, prostate, and liver surgery as well as to treat kidney stones. [Boston Globe, Oct 9, 09]

<="" a="">Polatis (Andover, MA)

Polatis (Andover, MA; no SBIR) said it has raised $8 million in venture capital. .... specializes in all-optical switch technology. [Boston Globe, Jun 2,09]

<="" a="">Polychromix (Wilmington MA)

Polychromix (Wilmington, MA; $600K SBIR) an innovative developer of material analysis and chemical sensing technologies, announced a strategic investment and development agreement with In-Q-Tel [company press release, Oct 1, 07] 

Polychromix (Wilmington MA; $600K SBIR) which employs 20 people, develops a handheld device designed to analyze various materials for the U.S. military and intelligence agencies, got an investment from In-Q-Tel (CIA's VC) which also plans to help Polychromix commercialize its technology for a range of government security agencies.  [Mass High Tech, Oct 1, 07]

<="" a="">Polyera (Skokie, IL)

NIST TIP winners  $22 million in funding for nine research projects targeting innovative manufacturing technologies in fields ranging from biopharmaceuticals and electronics to renewable energy sources and energy storage:  Isogenis (Aurora, CO; $4.8M SBIR);  ActaCell,  (Austin, TX; no SBIR);  Engineered BioPharmaceuticals (Manchester, CT; no SBIR); Arsenal Medical  (Watertown, MA; no SBIR); Kent Displays (Kent, OH; $2.6M SBIR); Precision BioSciences (Research Triangle Park, NC; $340K SBIR); Ginkgo BioWorks (Boston, MA; one SBIR); Sinmat (Gainesville, FL; $4.4M SBIR); Polyera (Skokie, IL; no SBIR).  http://www.nist.gov/tip/tip_121510.cfm 

<="" a="">PolyMedica (Wakefield, MA)

 PolyMedica (Wakefield, MA; 2 Phase 1 SBIRs), provider of products for diabetics, has agreed to be acquired by a giant pharmacy benefits manager,  Medco Health Solutions for about $1.5 B cash.

<="" a="">PolyMedix (Radnor, PA)

PolyMedix (Radnor, PA; $8M SBIR) said it has stopped enrollment in two clinical trials for its new drug candidate PMX-60056 because of observations of reductions in blood pressure in some study patients.  [John George, Philadelphia Business Journal, May 10, 12]

PolyMedix (Radnor, PA; $4.2M SBIR) and the University of Massachusetts received a $750,000 [Army STTR] contract ... to conduct further testing on [multidrug resistant biofilm-embedded bacteria ]antimicrobial compounds [John George, Philadelphia Business Journal, Nov 16, 10] raised $20M in stock offering Nov 09

PolyMedix (Radnor, PA; $4.5m SBIR) received a $986,000 phase-II NIH grant to support the company’s development of antimicrobial compounds to treat a mouth infection. [John George, Philadelphia Business Journal, Sep 30 , 10]

PolyMedix (Radnor, PA; $3.6M SBIR) announced a public equity offering of up to $21 million. ... for development of an antibiotic and a heparin antagonist  [Philadelphia Business Journal, Nov 11, 09]

<="" a="">Polymer Technology Systems (Indianapolis, IN)

Polymer Technology Systems (Indianapolis, IN; no SBIR),  a diagnostic medical device maker, won Innovation of the Year for a line of products to rapidly determine cholesterol rates and other levels in blood.  The Mira Awards are sponsored by Techpoint. The private company founded in 1992 has sales representatives and/or distributors worldwide.[Indianapolis Star, May 19]

<="" a="">PolyPlus (Berkeley, CA)

PolyPlus Battery (Berkeley, CA; one 1999 SBIR) has landed a nearly $9 million investment from the U.S. Department of Energy to scale up production of new kinds of batteries.....  will ramp up production of advanced lithium-air, lithium-water and lithium-sulfur batteries.... to produce the batteries at factory scale, ... to extend the driving range of electric vehicles.[George Avalos, Oakland Tribune, Jun 12, 12]  founded 1991 ... 27 employees including 7 PhDs [company website] Why government money for what should be an ROI investment?  faces one big technical problem: Its lithium-air battery can be recharged just 40 to 50 times, vs. thousands of times for traditional lithium-ion batteries [Alexandra Dean, Bloomberg Business Week, Apr 5, 12]  DOE is desparately pushing efficient batteries for the political dream of a nationwide adoption of electric autos in the windstorm of private market resistance.

ARPA-E Awards. The administration announced $106M in ARPA-E stimulus awards. Small biz winners:  Ginkgo BioWorks (Boston, MA; one SBIR) $6M primary;  OPX Biotech (no SBIR) $6M primary; Logos Tech (Arlington, VA; $2M SBIR) secondary; Sion Power (Tucson, AZ; $250K SBIR) $5M primary; ReVolt Tech (no SBIR) $5M primary; PolyPlus Battery (Berkeley, CA; one SBIR) $5M; Pellion Tech (no SBIR) $3.2M primary; A123 Systems  secondary, twice;  Planar Energy Devices (no SBIR) $4M; Maxpower (Harleysville, PA; $9M SBIR) secondary; NanoLab (Newton, MA; $5M SBIR) secondary; Codexis (no SBIR) $4.6M; Nexant (no SBIR) secondary.

PolyPlus  (Berkeley, CA; $100K SBIR a decade ago)  is developing lightweight, high-energy batteries that can use the surrounding air as a cathode.  is partnering with a manufacturing firm to develop single-use lithium metal-air batteries for the government, and it expects these batteries to be on the market within a few years. The company also has rechargeable lithium metal-air batteries in the early stages of development that could eventually power electric vehicles that can go for longer in between charges.  [Katherine Bourzac, MIT Tech Review, Jun 26, 09]

<="" a=""> PolyRemedy

<="" a=""> Polystor

UltraCell  (Livermore, CA; $800K SBIR) will get $1 million from the state of Ohio to help move more of its manufacturing operations to the Dayton region. .. has production operations in the area, recently landed a $3 million contract [funded by stimulus dollars] with the USAF to develop portable fuel cells for use by soldiers in the field.  ...  raised $3.8 million in venture funding to help expand operations at its facility in Dayton. ... has raised $30 million total since it was started in 2002 [Dayton Business Journal, Dec 18, 09] launched with technology licensed from Lawrence Livermore National Laboratories ...  [In 2007] it planned to invest $74M in the Dayton operation. The state has promised $15.2M in loans, grants and tax credits.  [Dayton Business Journal, May 15, 07]  portfolio.com lists James Kaschmitter as Chairman & CEO. Kaschmitter had a battery firm Polystor ($500K SBIR in 1996) and founded PowerStor (no SBIR) in 1997 as a spin-off from PolyStor [allbusiness.com, Dec 99].

Wha'ppen Polystor? The story is simple and heart-warming for government R&D types. Polystor started life with a DARPA contract that allowed the founder to skip out of Livermore Labs (which was looking for ways to de-populate). A BMDO Phase 2 SBIR followed which induced a British company to toss in money which led to a mass production Army contract in 1999 plus $9.5M from the Advanced Battery Consortium and an ATP grant. PolyStor was the first Li-ion battery producer in the United States and the first to use a nickel cobalt oxide cathode that delivers the highest capacity and energy density in the industry, says Branscom et al. In winter 2001 the firm employed roughly 150 people, with a staff of 35 in research and development. In 2002, Polystor ceased operations. Sweet story ends. Which suggests several hard questions for the government advocates:  1) Why did all that government money not produce a sustainable economic winner? ; 2) Is the battery powered vehicle still a government pipe-dream?; 3) Did the government ever ask whether that technology at that price could survive in a competitive market place especially in a company nurtured by government handout?; 4) How much government money is too much?

<="" a="">Portola Pharmaceuticals (San Diego, CA)

Accumetrics (San Diego, CA; no SBIR) develops, manufactures, and markets the VerifyNow® System, a comprehensive suite of tests for the assessment of platelet response to antiplatelet therapies. ...  signed an agreement with Portola Pharmaceuticals, (South San Francisco, CA; $500K SBIR) to develop and supply the VerifyNow System and VerifyNow Tests for use in clinical trials. [Accumetrics company press release] has raised $24 million from investors since 2009 .. employs 70 people [signonsandiego.com, Mar 2, 11]

<="" a="">Possis Medical

Possis Medical (Minneapolis; $250K SBIR) up 35% [Feb 11, 08] as it sold itself to Bayer for $344M.

<="" a="">PowerGenix (San Diego, CA)

in hybrid vehicles like the Toyota Prius and the Ford Focus. When they're stopped, so are their engines. When the driver presses down on the accelerator, powerful batteries start the engine and move the car Dan Squiller, chief executive of Scripps Ranch-based battery maker PowerGenix (no SBIR), is betting that technology will spread to other cars too, as it has in Europe. ... a good match for the nickel-zinc rechargeable batteries PowerGenix has been developing over the last decade.  [Onell Soto, signonsandiego.com, May 25, 11]

Army's venture venture.  The Army's VC (OnPoint Tech) current investment portfolio : A123 Systems (Boston, MA; $750K SBIR, IPO 2009) advanced Lithium-Ion based cells for rechargeable battery packs;  Atraverda (UK) advanced bi-polar battery electrodes for rechargeable batteries;  Integrated Fuel Cell Technologies  (Burlingto MA; no SBIR) next generation fuel cell systems for portable devices;  Nanosolar (Palo Alto, CA; $1.7M SBIR) thin-film solar technology for roll-to-roll printing of solar cells on flexible substrates,   PowerGenix (San Diego, CA; no SBIR) next-generation rechargeable batteries; Power Precise (Herndon, VA; no SBIR) a fabless semiconductor company specializing in battery management devices; Ultra Cell (Livermore, CA; no SBIR) integrated fuel cell systems; Zinc Matrix Power (Santa Barbara, CA; no SBIR) high-performance rechargeable alkaline battery technology for commercial and military markets;  Akermin (St Louis, MO; no SBIR) portable fuel cells based on its proprietary “Stabilized Enzyme Biofuel Cell” SEBC™ technology; Superprotonic (Pasadena CA; $200K SBIR) solid acid fuel cell.  [defense-ventures.com]  No surprise that a VC, even one doing it for the government, sees tech opportunity much different than does Army SBIR. I note that the three outside trustees (of five trustees) of OnPoint are a DOD political appointee, and entrepreneur/attorney, and Paul Gompers from Harvard Business School who with Josh Lerner publish a lot of venture research. Lerner did a lot of SBIR study until, I presume, he gave up on SBIR's ever being anything but a political handout.

PowerGenix (San Diego, CA; no SBIR; founded Y2K) is still a pip-squeak, having raised only $61 million from venture capitalists and praying for revenue of $10 million this year. ...  In December it began selling its AA rechargeable nickel-zinc batteries in Ritz Camera stores. It now has agreements to deliver $70 million worth of its batteries over the next three years to makers of power tools, garden tools and electric scooters and bicycles; shipping starts this fall. The attraction: Zinc is plentiful, nontoxic, recyclable and enables production of batteries with a high rate of discharge. ...  Says Lux Research Senior Analyst Ying Wu, "PowerGenix is the cheaper option, for now, and it has strong performance." But if the price of lithium-ion cells drops, Wu says, PowerGenix will be challenged.   [Kerry Dolan, Forbes, May 11]

Zinc Power. PowerGenix (San Diego, CA) landed a $17M round of financing in November ... For the past few years, PowerGenix has been developing a battery that it says is as much as 75% lighter, 30% smaller and 10 times as powerful as existing nickel-cadmium or nickel-metal hydride batteries. [Wall Street Journal, Jan 29, 07] No SBIRs yet.

<="" a=""> Powerlight (Berkeley CA)

Powerlight, of Berkeley, CA, a large venture-backed solar installer, ..just won a contract to help build the world's largest solar photovoltaic power project: a 11-megawatt solar power plant in Serpa, Portugal. [http://www.siliconbeat.com/, Apr 29, 06]

<="" a=""> Power Precise Solutions

Army's venture venture.  The Army's VC (OnPoint Tech) current investment portfolio : A123 Systems (Boston, MA; $750K SBIR, IPO 2009) advanced Lithium-Ion based cells for rechargeable battery packs;  Atraverda (UK) advanced bi-polar battery electrodes for rechargeable batteries;  Integrated Fuel Cell Technologies  (Burlington MA; no SBIR) next generation fuel cell systems for portable devices;  Nanosolar (Palo Alto, CA; $1.7M SBIR) thin-film solar technology for roll-to-roll printing of solar cells on flexible substrates,   PowerGenix (San Diego, CA; no SBIR) next-generation rechargeable batteries; Power Precise (Herndon, VA; no SBIR) a fabless semiconductor company specializing in battery management devices; Ultra Cell (Livermore, CA; no SBIR) integrated fuel cell systems; Zinc Matrix Power (Santa Barbara, CA; no SBIR) high-performance rechargeable alkaline battery technology for commercial and military markets;  Akermin (St Louis, MO; no SBIR) portable fuel cells based on its proprietary “Stabilized Enzyme Biofuel Cell” SEBC™ technology; Superprotonic (Pasadena CA; $200K SBIR) solid acid fuel cell.  [defense-ventures.com] No surprise that a VC, even one doing it for the government, sees tech opportunity much different than does Army SBIR. I note that the three outside trustees (of five trustees) of OnPoint are a DOD political appointee, and entrepreneur/attorney, and Paul Gompers from Harvard Business School who with Josh Lerner publish a lot of venture research. Lerner did a lot of SBIR study until, I presume, he gave up on SBIR's ever being anything but a political handout.

The Army is about to start using technology that measures the remaining power in batteries, developed by Herndon, Va.-based PowerPrecise Solutions, which received an investment from [Army VC] OnPoint in March 2004. The Army expects to save $65 million a year with the new product. It has put $61.8 million into the fund since Congress mandated its creation in the fiscal 2002 Defense Appropriations Act. .. The other Army "VC" investments: higher power density fuel cell system based on generating hydrogen from highly concentrated methanol for use in portable electronics (UltraCell); advanced rechargeable batteries based on silver zinc (Zinc Matrix Power);thin-film solar technology (Nanosolar).  [Kimberly Palmer, GovExec, May 15]

<="" a=""> PowerVision (Belmont, CA)

<="" a=""> Pozen (Chapel Hill, NC)

A small Chapel Hill (NC) drug maker is teaming up with one of the world's largest pharmaceutical companies to create a painkiller that would neutralize a nagging side effect: stomach ulcers.  As part of the deal, Pozen would receive up to $375M in payments and bonuses from AstraZeneca, which is based in London. If the drug wins U.S. regulatory approval for patient use, Pozen also stands to earn even more in sales royalties through 2023. The company's stock jumped nearly 40% on Wednesday's news.  Pozen, a 10-year-old company with 35 employees, is demonstrating a talent coveted by many drug startups in the Triangle: attracting major corporate firepower to back experimental medicines. [Raleigh News and Observer, Aug 3]  No SBIR record.

<="" a="">Pranalytica (Santa Monica, CA)

Pranalytica (Santa Monica, CA; $500K SBIR) started as a developer of sensors for analyzing human breath for disease, but is now leading the quest to make small lasers that can knock down antiaircraft missiles. ... [Founder] At age 60, C. Kumar N. Patel had a resume of accomplishments few scientists could match. In a span of four decades, Patel invented the carbon dioxide laser, which revolutionized manufacturing and surgical procedures, obtained 38 patents and ran the physics and engineering departments at Bell Labs, a premier research operation historically attached to AT&T ...  left the relative comfort of academia, tapped his life savings and started a tiny technology company ....   Amid the rising concern about terrorists using chemical weapons, the Pentagon began looking for reliable, portable devices that could be used to detect chemical agents and explosives. Patel's technology looked promising. In 2004, the Defense Department awarded the company a $13-million grant. ...  Since that 2008 breakthrough with the anti-missile laser, Pranalytica has grown to 15 employees.  [Peter Pae, Los Angeles Times, Jan 26,09]

<="" a=""> Precision Biopsy

Allied Minds, a Boston-based investment firm specializing in early-stage university ventures, has partnered with the University of Colorado to establish Precision Biopsy LLC, which is developing an optical biopsy needle to be used in diagnosis of prostate cancer.  [Denver Post, Jul 16, 08]

<="" a="">Precision BioSciences (Research Triangle Park, NC)

NIST TIP winners  $22 million in funding for nine research projects targeting innovative manufacturing technologies in fields ranging from biopharmaceuticals and electronics to renewable energy sources and energy storage:  Isogenis (Aurora, CO; $4.8M SBIR);  ActaCell, (Austin,TX; no SBIR);  Engineered BioPharmaceuticals (Manchester, CT; no SBIR); Arsenal Medical (Watertown, MA; no SBIR); Kent Displays (Kent, OH; $2.6M SBIR); Precision BioSciences (Research Triangle Park, NC; $340K SBIR); Ginkgo BioWorks (Boston, MA; one SBIR); Sinmat (Gainesville, FL; $4.4M SBIR); Polyera (Skokie, IL; no SBIR).  http://www.nist.gov/tip/tip_121510.cfm 

<="" a=""> Precision Optics

Precision Optics (Gardner, MA; $400K SBIR two decades ago) has formed a deal with Intuitive Surgical Operations Inc., a surgical robotics firm in California, bringing $2.5 million to Precision Optics. ...  said it plans to continue pursuing its technology outside of medical robotics, focusing on its Lenslock endoscopes, Microprecision optical elements and handheld stereoendoscopes.   [Michelle Lang, Mass High Tech, Aug 5, 11]

Precision Optics (Gardner, MA; $500K SBIR) sold its optical filter line to a New Jersey company for $250,000 and a three-year royalty agreement  [Mass High Tech, Jan 22, 08]

Precision Optics which had a sliver of HHS SBIR money in the late 80s is in danger of de-listing for lack of $1 stock price for 30 days. 

Precision Optics, a bit HHS SBIR played in the late 80s, raised another $5M in a rights offering to buy the $1.30 stock at $1

<="" a="">Predictive Biosciences (Lexington, MA)

Predictive Biosciences (Lexington, MA;  no SBIR) announced the completion of a $25 million Series C round of growth capital financing. ... describes itself as a commercial stage, fully-integrated developer of novel molecular diagnostic cancer assays and a provider of anatomic pathology laboratory products and services  [Boston Globe, Jun 16, 10]

Predictive Biosciences (Lexington, MA; no SBIR) closed on a $21.75 million Series B financing to fund clinical trials for its oncology testing assays. The -based firm stated it would use the capital to develop its urine-based test that can detect the presence of cancer. The firm plans to launch a multi-center clinical trial for patients with recurring bladder cancer in 2009. A portion of the money will also be used to establish a new independent laboratory. [Mass High Tech, Oct 16, 08]

<="" a=""> Presage Biosciences (Seattle, WA)

<="" a=""> Pressure BioSciences (South Easton, MA)

Pressure BioSciences  (South Easton, MA, one SBIR), a 2009 Larta NIH-CAP company focused on the development of novel instruments and solutions to the error prone nature of biological sample preparation, has recently entered in to a distribution agreement with Netherlands-based LA Biosystems BV to market and sell their instruments in Belgium, the Netherlands, and Luxembourg. This follows on the coattails of a collaboration with the Henry C. Lee Institute of Forensic Science and international co-marketing and distribution agreements with KeraFAST LLC (USA), Digilab Inc. (USA), OROBOROS (Austria) and IUL Instruments GmbH (Germany).  [LARTAVox,  Mar 21, 12]

Pressure BioSciences (South Easton, MA;  one SBIR) completed an $800,000 private placement  ...   to support commercialization of its Pressure Cycling Technology platform, which uses rapid cycles of hydrostatic pressure between ambient and ultra high levels to control biomolecular interactions.    [Michelle Lang, Mass High Tech, Feb 9, 12]

On the heels of receiving $112,000 in loans from three of its investors, Pressure BioSciences (South Easton, MA; one SBIR) was awarded [$650K DOD SBIR] ... help fund the development of an automated, high-throughput, high-pressure system, including instruments and consumables, for safe and accurate processing of pathogenic organisms such as viruses and bacteria. [Lori Valigra, Mass High Tech, Oct 14, 11]

Pressure BioSciences (South Easton, MA; one SBIR)  was awarded a $649,498 [SBIR] grant from the U.S. Department of Defense....  will help fund the development of an automated, high-throughput, high-pressure system, including instruments and consumables, for safe and accurate processing of pathogenic organisms such as viruses and bacteria. The system will be based on the company’s pressure cycling technology, which uses rapid cycles of hydrostatic pressure between ambient and ultra high levels to control biomolecular interactions. ... a substantial portion of the remaining development costs of a new system aimed at the sample preparation market. He estimated the size of that market at $6 billion, including approximately 80,000 laboratories and 500,000 researchers worldwide. [Lori Valigra, Mass High Tech, Oct 14, 11]  Sounds an awful lot like merely reducing business risk for a working technology which competes with private capital and enters the territory of corporate welofare.  Ah well, DOD likes certainty in its spending.

Pressure Biosciences (no SBIR) has pulled in $1.2 million through a combination of equity, warrants and securities.  [Mass High Tech, Dec 4, 09]

Pressure BioSciences (South Easton, MA; no SBIR) sold about $1.16 million in stock and warrants, as a first tranche of a $2.5 million private placement. [Mass High Tech, Nov 19, 09]

Pressure BioSciences (South Easton, MA; no SBIR, 27 employees) has announced restructuring steps, including a 40 percent reduction in workforce, closing of a research facility in Rockville, Md., and widespread cost reductions  ... will focus on Pressure Cycling Technology (PCT) for the mass spectrometry market, as well as the biological sample preparation market. Other company projects not related to the new strategy will be terminated.  [Mass High Tech, Dec 2, 08]

<="" a="">Prevention Pharmaceuticals (New Haven, CT)

Prevention Pharmaceuticals (New Haven, CT; no SBIR) has sold $650,000 of a $2 million securities offering, through a combination of debt, options and warrants .... to introduce an OTC zinc-salts heartburn gel cap called Acid-Fix that is based on technology out of Yale University [Lori Valigra, Mass High Tech, Jan 13, 11]

<="" a=""> Primera Biosystems

Primera Biosystems (Mansfield, MA; no SBIR) reports it has closed on a $20 million Series C round of financing, ... a molecular diagnostics company developing a proprietary nucleic acid analysis system [Mass High Tech, Sep 21, 09]

Molecular diagnostics company Primera Biosystems (Mansfield, MA; no SBIR) closed on a $21M Series B financing led by a British investment firm ... has operated quietly since it closed an $11M Series A financing in 2005. [Mass High Tech, Jan 8, 08]

<="" a=""> Primorigen Biosciences

Primorigen Biosciences LLC got a Phase I SBIR grant of $362,714 from NIH. The grant allows the Madison biotech company to compete for an additional $1.6 million grant in the future, company executives said. Primorigen is developing new antibodies and other products for cell therapy research. ... will accelerate Primorigen’s development of a new protein detection test to support cell research on Type I diabetes, the company said.  [Milwaukee Journal-Sentinel, Sep 4, 08]

<="" a=""> Prism Solar Technologies (Lake Katrine, NY)

solar-power startups in particular have seen a three-year surge, from a low of no venture investment in the third quarter of 2005 to a high of more than half a billion dollars in the second quarter of this year.  CaliSolar (Sunnyvale, CA; no SBIR) $13M; Wakonda Technologies (Fairport, NY; $200K SBIR) $9M; Prism Solar Technologies (Lake Katrine, NY; no SBIR) $9M. [Dean Takahashi, MIT Tech Review, S/O 08]

<="" a="">ProCertus BioPharm (Madison, WI)

Other [Wisconsin] companies the MoneyTree report showed raising venture funding in the second quarter were: Aquarius Technologies (Port Washington, WI; no SBIR) developer of wastewater treatment technologies, $4 million; NeuWave Medical (Madison, WI; no SBIR) medical device company, $2.63 million; ProCertus BioPharm (Madison, WI; $1.6M SBIR) drug developer, $1.7 million; and Zurex Pharma (Madison, WI; no SBIR) drug developer, $1 million.  [Kathleen Gallagher, Milwaukee Journal Sentinel, Jul 19, 11]

ProCertus BioPharm (Madison, WI; $1.6M SBIR) has raised $1.7 million to fund clinical trials to determine whether its products can safely help cancer patients avoid side effects of radiation and chemotherapy. ... ProCertus' products are applied to skin or the inside of the mouth minutes before cancer therapy to protect cells that will be exposed to chemotherapy and radiation.  [Kathleen Gallagher, Milwaukee Journal Sentinel, Apr 5, 11]

ProCertus BioPharm  (Madison, WI; $1.6M SBIR), developing drugs to protect cancer patients from common chemotherapy and radiation side effects will announce Tuesday it has raised $2.1 million. ...  has also started enrolling patients in a clinical trial to determine whether its DermX product prevents burns caused by radiation therapy, said Paul Weiss, the company's acting chief executive officer. ....  ProCertus licenses its technology from the Wisconsin Alumni Research Foundation. The company raised $2.3 million in 2007. [Kathleen Gallagher, Milwaukee Journal Sentinel, Jun 30, 09]

<="" a="">Profectus BioSciences (Baltimore,MD;

Profectus BioSciences (Baltimore, MD; $1M SBIR) was awarded a total of $6.25 million in funds from the [NIH]. ...includes three SBIR grants totaling $2.9 million. ... develops vaccines for chronic viral diseases  ... grants are in addition to $4.4 million the company recently secured. Those funds included an SBIR grant of $3.1 million ...   an HIV and cancer research company, is a spinout from the Institute of Human Virology formed to commercialize research spearheaded by Dr. Robert C. Gallo, the famed AIDS co-discoverer who oversees the institute. [Emily Mullen, Baltimore Business Journal, Oct 7, 10]

<="" a="">Progenics Pharmaceuticals

Proteon Therapeutics  (Kansas City, MO; $250K SBIR), a developer of drugs for kidney and vascular disease, has brought in another $15.2 million in equity- and options-based funding says an SEC filing  [Erin Kutz, xconomy.com, Aug 12, 11]

Proteon Therapeutics  (Waltham, MA (research in KC); $200K SBIR) has received an additional $12 million in venture capital. ... developing a blood vessel-dilating drug candidate [Kansas City Business Journal, May 28, 09]

Biopharmaceutical startup Proteon Therapeutics (Waltham, MA; $250K SBIR) has completed a $38 million Series B equity financing deal and has signed a deal with Novartis worth a potential half billion dollars  [Mass High Tech, Mar 5]

Proteon Therapeutics (Waltham, MA and KC, MO; 2 SBIRs)  reports it has been awarded a patent by the European Patent Office covering the use of a class of proteins known as elastase, for dilating arteries and veins in humans.

Biopharmaceutical company Proteon Therapeutics (Waltham, MA; two Phase 1SBIRs) has locked up $12M financing following last year's $19M. ... to advance its first product candidate, PRT-201, into human clinical studies in both hemodialysis vascular access and peripheral arterial disease [Mass High Tech, Sep 6, 07]

<="" a=""> Proteostasis Therapeutics

Proteostasis Therapeutics (Cambridge, MA; no SBIR) has added to its three-year-old Series A funding, boosting it from a planned $5 million to taking $70.6 million of what is now a planned $81.8 million round ... developer of a drug discovery platform aimed at developing therapeutics based on small molecules for Parkinson’s disease, Huntington’s disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease.  [Rodney Brown, Mass High Tech, Jun 2, 11]

David Pendergast, the former CEO who led Transkaryotic Therapies through its sale to Shire Pharmaceutical Group, has helped new startup Proteostasis Therapeutics (no SBIR) raise $45 M in its first round, the company said.  Proteostasis was founded on the research of Jeffrey Kelley of the Scripps Research Institute in California and Susan Lindquist of the Whitehead Institute for Biomedical Research at MIT.  [Mass High Tech, Aug 25]

<="" a="">Proteotech

In Washington state’s biotech cluster, 83 local biotech companies were awarded grants worth a combined $34 million,   Adaptive TCR, AVI Biopharma, Omeros, Proteotech, and Trubion Pharmaceuticals and 78 others. [Luke Timmerman, Seattle Times, Nov 3] Most were $245K, a little money for almost everyone. Too little money to make a big swing in effect. Just politics.

<="" a="">Proteus Biomedical (Redwood City, CA)

It’s hard to find a better example of how technology is revolutionizing patient care than the tiny edible sensor Proteus Biomedical (Redwood City, CA; no SBIR) plans to begin selling this fall in the UK.  When the grain-of-sand-sized sensor is integrated into a drug tablet or capsule and activated by stomach fluid, it signals when the medicine was taken to a patch on the patient’s body. Then the patch relays the information along with the person’s heart rate and other medical details to a caregiver’s phone – all without a visit to the doctor.  [Steve Johnson, San Jose Mercury News, Mar 26, 12]

Proteus Biomedical  (Redwood, CA; no SBIR) a seven-year-old start-up, that is working on "smart pills" — internal sensors that monitor a person's health ... has lined up more than $60 million in funding and will concentrate for now on designing smart pills that monitor mechanical and electrical devices, as opposed to, say, blood chemistry.  [Josh Quittner, Time, Dec 15, 08]

A system that monitors pill taking and its effects is being engineered by a Silicon Valley startup. The technology consists of pills that report when they've been taken, and sensors that monitor the body's responses. The company behind the technology, Proteus Biomedical, (Redwood City, CA; no SBIR), calls its technology the Raisin system. George Savage, Proteus's cofounder and a former ER physician, says that the company was motivated by the fact that so many medical problems stem from drug compliance problems. According to Savage, 40 percent of hospital readmissions for heart failure happen because patients fail to take their medications properly. [Michael Chorost, MIT Tech Review, Mar 20]

<="" a=""> Protez Pharmaceuticals (Malvern, PA)

Novartis AG purchased Protez Pharmaceuticals (Malvern, PA; no SBIR) a.developer of antibiotics, this week for $400 M cash. [Pittsburgh Business Times, Jun 6]

<="" a="">ProThera Biologics (Providence, RI)

ProThera Biologics (East Providence, RI; $3M SBIR) received a $500,000 financing commitment from the Slater Technology Fund, according to Slater. Slater reports that the $500,000 commitment follows its initial $100,000 grant to ProThera in 2001. [Mass High Tech, Jun 25]

<="" a="">Proto Labs (Maple Plain,MN)

Medical devices start-ups powered Minnesota to the best quarterly VC performance in eight years just as a sagging economy curbed venture spending across the country. ... Seven medical device firms captured $130 million, led by CVRx (Brooklyn Park, MN; no SBIR) that makes a device that treats high blood pressure, raised $84 million on top of the $200 million investors have already poured into the company.  Cardiac Concepts  (no SBIR) first-round financing totaled a hefty $21 million. ... Other notable deals: Proto Labs (Maple Plain, MN; no SBIR) -based maker of injection molded products, attracted $67.2 million. Sage Electrochromics (Faribault, MN; $2M SBIR) raised $13.3 million, which makes glass that influences building temperatures, previously won $16 million in venture financing.  [[Minneapolis Star Tribune, Oct 26, 08]

<="" a=""> Proton Energy Systems (Wallingford, CT)

New England energy stimulus money for small biz:  $2.2 million for an energy storage project at Beacon Power  .... $2.1M for Proton Energy (Wallingford, CT; $1.7M SBIR) and Penn State University aim to develop an advanced energy storage device that incorporates a regenerative fuel cell  ....  General Compression, (Newton , MA; no SBIR)  $750K for a novel compressed air energy storage process [Kyle Alspach, Mass High Tech, Jul 13, 10]

Fuel Your Senators.  Proton Energy Systems (Wallingford, CT; $1.3M SBIR), a renewable hydrogen technology developer, has received a $2.62 million Army contract fto develop a regenerative fuel cell system, company officials said.... The two US Senators helped secure funding for the project. ...  In August, Proton announced being bought from its parent company Distributed Energy Systems Corp. by F9 Investments LLC for $10.2 million. [Mass High Tech, Oct 16, 08]

Proton Energy Systems (Wallingford, CT)  got a $2.3 million contract for a hydrogen technology-oriented follow-on research project for the development of fuel cell technologies [Nov 06]

High Flying Hydrogen. MDA gave Proton Energy Systems (Wallingford CT) got a $1.25M SBIR Phase 3 for continued development of regenerative fuel cell technology for high altitude airships. Proton is a a subsidiary of Distributed Energy Systems.  [Mass High Tech, Oct 12]  Phase 3, which isn't SBIR money, lets the government hand out a contract to the Phase 2 winner without further competition. The company is also in the middle of a three-year, $3.8 M project with the Department of Energy to develop methods to reduce the cost of high-pressure hydrogen generation from proton exchange membrane electrolysis.

<="" a="">Protonex Technology  (Southborough, MA)

Protonex Technology said it has been selected by the defense contractor Lockheed Martin to develop power supply concepts that will enable its HULC robotic exoskeleton to support extended missions of 72 hours or more. [Boston Globe, Feb 11, 10]

Protonex Technology reports it has landed $1.5 million from the U.S. Army for supplying portable battery charger fuel cells. [Mass High Tech, Feb 4, 10]

Protonex Technology landed a [Army and stimulus] contract worth $1.85 million for the development and supply of advanced portable battery charger/auxiliary power units (APU) fuel cell systems. ... could increase to $6.4 million if three option phases are awarded.  [Mass High Tech, Jan 20, 10]

A small unmanned aerial vehicle powered by a Protonex fuel cell has set an unofficial endurance record after a flight of more than 23 hours, the company. said. [Boston Globe, Oct 15, 09]  The Navy sponsored the project.

Protonex Technology got a $2 million follow-on contract from the U.S. Army to make Protonex’ solid oxide fuel cell (SOFC) power systems more rugged and robust to meet the Army’s needs. [Mass High Tech, Sep 22, 09]

Protonex Technology (Southborough, MA; $1.8M SBIR) announced Thursday it received a $599,000 contract with the U.S. Naval Research Laboratory to develop fuel cell power systems for aerial drones.  [Mass High Tech, Sep 17, 09]

Protonex Technology (Southborough, MA; $2M SBIR) said its fuel-cell power system has been successfully tested in a Talon military robot from Foster-Miller. [Boston Globe, Apr 21]

Protonex Technology won a $400,000 contract from the Army's ARO for further development of the use of high-performance liquid fuels in its solid-oxide fuel cell power systems.  .... In April, Protonex received a $3.65 million contract from ARO to develop the next generation of the firm’s Pulse M250 military power system. [Mass High Tech, Sep 9, 08]

Protonex Technology landed its second military contract in two weeks, receiving a $3.65 million contract from the Army. [Mass High Tech, Apr 28]

Protonex Technology (Southborough, MA) got a $1.62 M contract with the NRL for advanced development of high power fuel cell systems for small UAVs.  ... makes fuel cells for commercial use. It began working with Cummins on applications in the trucking industry last September. ... shares debuted on the London Stock Exchange last July  [Mass High Tech, Apr 23, 08]

Protonex reports a new subcontract from Cummins to supply solid oxide fuel cell (SOFC) power systems for integration into a demonstration system for commercial mobile applications. [Mass High Tech, Sep 24, 07]

Protonex reports Raytheon has agreed to participate in the development of Protonex' portable fuel cell power system for the Army. ... Since going public last July on London's Alternative Investment Market (AIM), Protonex has doubled its head count from about 40 employees last year to 85 employees. [Mass High Tech, Sep 12]

Protonex was up 20%, back to the 90s after a drop and a day off from trading. [Jul 6, 07]

Protonex took an 18% swan dive despite announcing an $800K AF contract extension. [Jul 3, 07]

Protonex Technology (Southborough, MA; $1M SBIR) which makes high-performance proton exchange membrane (PEM) fuel cells will pay $12M for Mesoscopic Devices (Broomfield, CO; $5M+ SBIR) which makes a range of fuel cells.

They Still Speak English. Ross Kerber [Boston Globe, Jan 28] notes that four Boston area companies have gone public recently by listing on the London AIM exchange. Of the four, fuel cell developer Protonex Technology had about $1M in SBIR, and fish farmer Aqua Bounty had just one Phase 1. 

<="" a="">Prototype Productions (Ashburn, VA)

Prototype Productions (Ashburn, VA; $1.4M SBIR)  built or invented 176 gadgets over the years, spanning the defense, aerospace and medical industries. They’ve made stuff for the Patriot missile, grenade launchers and Chinook helicopters. ...  hoping to [gross] $30 million to $50 million by mid-decade. ...  90 employees ... During our tour, Joe took me to a room and pointed at a box the size of two refrigerators. He called it a 3D laser printer. It’s too technical to get into, but he said the printer is the next advance in manufacturing. “Many say America is losing its industrial base, which is true to some extent,” he said. “But in the future, we won’t worry about this because we will no longer manufacture things. We will print things. Laser centering is the next trillion-dollar industry.”    [Thomas Heath, Washington Post, Apr 25, 11]

<="" a="">Provagen

Two spinoff companies from N.C. State University and N.C. A&T State University are the first to receive loans and legal help from a new set of programs designed by the N.C. Biotechnology Center in Research Triangle Park. The programs offer companies $50,000 in startup loans as well as free legal help from area law firms. ... NCSU's company, Sirga Advanced Biopharma, uses the technology of biochemistry professor Paul F. Agris to identify therapies for drug-resistant diseases ... A&T's spinoff company, Provagen, was formed to commercialize protein technology developed by John Allen, a molecular biologist.  [Raleigh News & Observer, Jun 22]

Provenance Biopharmaceuticals (Waltham, MA)

Provenance Biopharmaceuticals (Waltham, MA; no SBIR) has raised $8 million from brand new stealthy health care products acquisition company Allopexx Enterprises LLC to fund development of an anti-cancer therapy.   [Rodney Brown, Mass High Tech, Dec 23, 11]

<="" a="">Proventys

A Durham medical research company co-founded by Ralph Snyderman, former CEO of the Duke University Health System, has attracted interest from several health-care heavy hitters and enough cash to introduce its first product this year. Proventys (no SBIR) is working on software that promises to help prevent complications from chemotherapy by identifying at-risk cancer patients. The company plans to use part of its $5.65 million in private financing to test the technology, and it might target other therapeutic areas.  [Raleigh News & Observer, May 15, 08]

<="" a="">pSivida (Watertown, MA)

pSivida (Watertown, MA; no SBIR) has taken a $15 million payment from Alimera Sciences (Alpharetta, GA; no SBIR) to cover licensing of its lead product Iluvien to treat diabetic macular edema (DME).  ... pSivida was launched in Australia, and reincorporated as a U.S. company based in Watertown in April of 2008.     [Mass High Tech, Apr 29, 10]

<="" a="">PTC Therapeutics

Genzyme will pay PTC Therapeutics (Plainfield, NJ; $5M SBIR)  $100 million, as well as milestone and royalty payments, to commercialize its drug, PTC124, outside the U.S. and Canada, where PTC will commercialize the drug. [Mass High Tech, Jul 17, 08]

<="" a="">Pulmatrix (Lexington, MA)

Pulmatrix  (Lexington, MA; no SBIR), a clinical stage biotechnology company , said that it has secured $14 million in new funding in a Series B1 round ... to accelerate the development of its drug candidate pipeline. The company is focused on discovering and developing a new class of therapies for the prevention, treatment, and control of respiratory diseases.  [Chris Reidy, Boston Globe, Aug 15, 11]

Pulmatrix (Lexington, MA; no SBIR) said it has been awarded a $5.7 million grant from DARPA. ...  focused on new treatments for respiratory diseases, and the DARPA grant is for developing potential treatments for respiratory infections caused by weaponized, engineered, or naturally occurring pathogens  [Boston Globe, Dec 14, 10]

Pulmatrix (Lexington, MA; no SBIR) is starting a Phase 1b/2a clinical trial of its new inhaled influenza treatment PUR003, which possibly could be used against the current swine flu. .... said that its lead drug candidate PUR003 is a so-called Cationic Airway Lining Modulator drug. ... founded in 2003 by scientists from Harvard University and MIT with an eye to creating inhaled drugs and supporting technologies to treat and control disease. ... Earlier this year, Pulmatrix secured $3.5 million [VC]  [Mass High Tech, May 4, 09]

Pulmatrix (Lexington, MA; no SBIR) has closed on more than $3 million in a recent funding round.  Pulmatrix’s mission is to prevent the spread of airborne and respiratory infectious diseases in animals and humans with a mixed hardware-chemical combination. It was founded in 2003 by scientists from Harvard University and MIT with an eye to creating inhaled drugs and supporting technologies to treat and control disease.  [Mass High Tech, Mar 13, 09]

<="" a="">Purfresh (Fremont, CA)

<="" a="">QD Vision (Watertown, MA)

QD Vision (Watertown, MA; $1.7M SBIR)  reports it has won a $900,000 development contract from the Defense Advanced Research Projects Agency (DARPA) to make a pair of prototype devices based on its quantum dot infrared materials. ... In May QD Vision raised $22M to expand its quantum dot technology. [Rodney Brown, Mass HIgh Tech, Aug 17, 11]

QD Vision (Watertown, MA; $1.6M SBIR) has bought a patent portfolio related to using quantum dots – the QD in QD Vision – in display and lighting products from Motorola Inc., for an undisclosed amount.  ... plans to ship its first products, which include display backlight units used in cell phones, laptops and TVs, in 2011 [Mass High Tech, May 24, 10]

Barely one month after reporting a $10 million venture investment, QD Vision (Watertown, MA; $1.7M SBIR) says it has taken in $3 million from DTE Energy Ventures to help expand the market for its technology for LED lighting and displays products. [Mass High Tech, Jan 21, 10]

QD Vision (Watertown, MA; $900K SBIR) landed $10 million in its latest financing round ... developer of Quantum Light, which uses quantum dots to produce high output LEDs that draw less power than traditional products  [Mass High Tech, Dec 16, 09]

QD Vision (Watertown, MA; $900K SBIR) got an Army Phase 2 SBIR to continue the development of micro-displays based on the company’s quantum dot light emitting diode (QLED) technology. ... part of the firms VC backing comes from CIA's In-Q-Tel.  .... technology is based on the work of Vladimir Bulovic, an associate professor of electrical engineering and computer science at MIT, and Moungi Bawendi, a professor of chemistry at MIT focused on the synthesis of nanomaterials [Mass High Tech, Jun 9, 09]

QD Vision (Watertown, MA, $900K SBIR) is promoting a new LED-based lamp that it made with Nexxus Lighting (Charlotte, NC; no SBIR). Nexxus makes a lamp designed to screw into standard sockets used in recessed ceiling lighting. It consists of an array of white-light LEDs encircled by fins that remove excess heat. QD Vision adds an optic--a plastic cover with a special coating that snaps into place over the LEDs. It's that coating that makes the difference in the quality of the light. It consists of quantum dots--tiny bits of semiconductor material just a few nanometers in diameter. When excited by a light source--in this case, the LEDs--quantum dots radiate light in a wavelength that varies according to the size of the dot. [Neil Savage, MIT Tech Review, May 13, 09]

Following its recently announced funding from In-Q-Tel, the CIA venture arm, Watertown-based QD Vision (Watertown, MA; one SBIR) has also landed $9 M of an expected $16 M round of Series C funding from private investors, according to [SEC] documents [Mass High Tech, Apr 11]

<="" a="">Qioptiq (Fairport, NY)

<="" a="">QM Power (Boston, MA)

QM Power (Boston, MA; $700K SBIR) is looking for $5 million to $10 million in Series B funding to commercialize its technology ... “We’re moving now from a stage where we’ve finished research and development and prototyping and going into 2010 looking to start production,” [CEO] Piper said. Piper said there is a $1 trillion installed base of products that could be improved by QM Power technology, and he estimates a market potential of about $70 billion per year.  [Brendan Lynch, Mass High Tech, Jan 6, 10]

<="" a="">QR Pharma (Radnor, PA)

QR Pharma (Radnor, PA; no SBIR), a pharmaceutical company focused on developing treatments for Alzheimer’s disease, raised $2.4 million in a seed round of investments [John George, Philadelphia Business Journal, Jun 2, 10]

<="" a="">Qteros (Marlborough,MA)

Cellulosic ethanol company Qteros (Marlborough, MA; no SBIR) said it has raised $22 million in a Series C round and inked a partnership deal with a major Indian ethanol firm, which the company said gives it a clear path to commercialization within 18 to 24 months. [Kyle Alspach, Mass High Tech, Jan 5, 11]  Just as enthusiasm for US government subsidy is waning.

Qteros (Marlborough, MA; no SBIR)  and the University of Massachusetts Amherst have patented the fermentation method they use to make biofuel, a plant-based alternative to gasoline, using the so-called Q Microbe. [Erin Ailworth, Boston Globe, Mar 23, 10]

<="" a="">Quadraspec

Quadraspec (Purdue Research Park - West Lafayette, IN; no SBIR) received $2.5 million from venture capital firms led by Clarian Health Ventures of Indianapolis. ... makes a machine to diagnose diseases from a blood test. The technology can detect cancer, cardiovascular disease and other serious illnesses in their early, most treatable stages. [Indianapolis Star, SEp 13, 08]

<="" a="">Quadra-Aerrow International (Glastonbury, CT)

Six start-up technology firms have received grants as part of the state's small-business incubator program,  ... administered by the Connecticut Center for Advanced Technology ...  $32,000 to $50,000 went to: AllerQuest LLC of West Hartford, Catelectric Corp. of Storrs, Hydrogen Safety of East Hartford, Quadra-Aerrow International of Glastonbury, Revegen Inc. of Farmington and the Center for Network Centric Product Support Research of East Hartford.  [Hartford Courant, Dec 12, 08]  no SBIR for any

<="" a="">QualityMetric (Lincoln, RI)

QualityMetric (Lincoln, RI; $1.5M SBIR)  got a $2M NIH SBIR Phase 2 to develop tools to measure the health of people with asthma [Mass High Tech, Oct 16, 07]

QualityMetric (Lincoln, RI) got two NIH SBIRs totaling $1.1M to develop uses for its computerized adaptive testing technology.  ... QualityMetric executives say the company uses proprietary analytic methodologies to capture, benchmark, interpret and report on patient-based health information to use in the development of new treatments. [Mass High Tech, Nov 1,06]  QM has had several Phase 1s and one prior Phase 2.

<="" a="">Qualtech Systems (East Hartford, CT)

<="" a="">Qualtré (Marlborough, MA)

Qualtré (Marlborough, MA; no SBIR) which makes solid-state silicon MEMS motion sensors, announced the closing of a $10 million round of financing to help launch products targeting both high-volume consumer and industrial applications....   Founded in 2008, the company took in $8 million in Series B financing in 2010, and $10 million last July  [Don Seiffert, Mass High Tech, May 30, 12]

Qualtré (Marlborough, MA; no SBIR) an inertial sensor company  has raised $10 million from venture capital backers ... after the company gave a successful demonstration of its silicon MEMS bulk-acoustic wave gyroscope, which Qualtré said it intends to commercialize, ... cheaper to make and more accurate than current sensors   [Michelle Lang, Mass High Tevh, Jul 8,11]

Qualtré (Marlborough,MA; no SBIR) an inertial sensor company, has taken in $8 million in a Series B financing round ... solid-state multi-axis MEMS gyroscopes are intended for use in game controllers, mobile handsets and digital camera imaging. [Mass High Tech, Apr 22, 10]

<="" a="">Quanterix (Cambridge, MA)

<="" a="">Rain Water Solutions (Raliegh, NC)

Thirteen NC companies will split $1 M from a new state fund intended to help businesses create environmentally friendly technologies. In the Triangle area: Ecocurrent of Raleigh received $100,000 to convert hog manure into electric power; Kyma Technologies of Raleigh received $60,000 to work with N.C. State University on a more efficient, cheaper electric switch.; 3F LLC of Raleigh received $100,000 to develop a natural fiber-reinforced concrete formula.; Piedmont Biofuels of Pittsboro received $75,000 to work on a reactor that more efficiently creates biodiesel.; Nextreme Thermal Solutions of Durham received $57,319 to manufacture a generator that converts waste heat into electricity.; Rain Water Solutions of Raleigh received $18,000 to develop a new rain barrel manufacturing process. [Raleigh News & Observer, Jul 1]

<="" a="">RaNA Therapeutics (Cambridge, MA)

RaNA Therapeutics (Cambridge, MA; no SBIR). said it has completed a $20.7 million round of financing co-led by Atlas Venture, SR One, and Monsanto, with participation of Partners Innovation Fund.  ... is developing a technology platform to enable selective activation of target genes. [Chris Reidy, Boston Globe, Jan 18, 12]

Stealthy startup RaNA Therapeutics  (Cambridge, MA; no SBIR) raised $2.66 million of a planned $20.66 million initial funding, according to federal documents. [Rodney Brown, Mass High Tech, Dec 1, 11]

<="" a="">Range Fuels (Broomfield, CO)

Range Fuels (Broomfield, CO; no SBIR), a cellulosic ethanol company backed by as much as $156 million in U.S. loans and grants from[Bush] administration, is being forced by the government to liquidate its only factory [in Soperton, GA] after failing to produce the fuel. [Mario Parker, Bloomberg News, Dec 3, 11]

The Range Fuels (Broomfield, CO) plant, to be located in southeast Georgia, could be producing ethanol as soon as next year. It's being funded [$76M to the company for the construction] by the DOE as part of the agency's effort to increase the use of biofuels. [Kevin Bullis, MIT Tech Review, Nov 15] Those logs streaming down I-16 to the Savannah port can be diverted to making cellulosic fuel that is eons away from market economics until a new killer chemistry appears. From an economy standpoint, investing in chemistry is a lot cheaper than production plants for known uneconomical chemistry. But then, they wouldn't be pouring millions of pork into Georgia.

<="" a="">Ra Pharmaceuticals (Boston, MA)

Ra Pharmaceuticals (Boston, MA; no SBIR) has pulled in $10.3 million of a planned $27.6 million equity round of financing, according to [SEC] filing. [Mass High Tech, Feb 26, 10]

<="" a="">Rapid Diagnostek (Hudson, WI)

Rapid Diagnostek (Hudson, WI; no SBIR) has raised $4 million of venture capital ... to develop a portable, one-step sensing device that could quickly diagnose diseases, bacteria, viruses, and spores by analyzing blood, urine and saliva. The company moved to Hudson in 2008 from Minnesota. [Kathleen Gallagher, Milwaukee Journal Sentinel, Jan 26, 10]

Aldevon (Fargo, ND; no SBIR), maker of DNA and protein products is putting a research and sales operation in [Wisconsin] ....  founded by two ND State U graduates, has more than 70 employees, and provides products and services to pharmaceutical companies and diagnostic test-makers.  ... also welcomed to Wisconsin: RJA Dispersions (no SBIR), VitalMedix (no SBIR) and Rapid Diagnostek (no SBIR), from Minnesota; Flex Biomedical (one SBIR) and Exact Sciences (no SBIR), from Massachusetts; NanoMedex ($1M SBIR), from Florida; and Inviragen ($2M SBIR) from Colorado. Biotechnology is the fastest-growing segment of the Wisconsin economy, with an annualized growth rate of nearly 7%, [Gov] Doyle said in a statement. The sector has 400 companies in the state with 34,000 employees.

Six start-ups will be recognized for making strides to commercialization at a biotech industry summit in October. ... part of a one-day Biotechnology Vision Summit 2009 that is being run by BioForward, an organization that represents Wisconsin's biotech industry. AquaMost LLC (Madison, WI; one SBIR) , Echometrix  (Madison, WI; no SBIR), Flex Biomedical Inc(Madison, WI; one SBIR), Semba Biosciences (Madison, WI; no SBIR),  Invivosciences LLC (Wauwatosa, WI; no SBIR), and Rapid Diagnostek Inc  (Hudson, WI; no SBIR).  [Kathleen Gallagher, Milwaukee Journal Sentinel, Sep 22, 09]

Moving for Subsidy.  Lured by the state's tax credits for investments in high-growth companies, a  biotech start-up said it was moving to Wisconsin. VitalMedix (Minneapolis, MN; no SBIR) is developing a drug that first responders, trauma center surgeons and military medics could use. The drug, Tamiasyn, has the potential to allow humans to endure severe blood loss and inhibit organ damage during resuscitation. ....  Minnesota legislators tried to create a similar program but failed. ....  The credits had lured another biotech company. Rapid Diagnostek (no SBIR) moved to Hudson last year from St. Paul to take advantage of the credits. The top executive at BioE (no apparent SBIR) a Twin Cities tech company, praised Wisconsin's embrace of tech companies and didn't rule out a move.  [Kathleen Gallagher, Milwaukee Journal Sentinel, Jul 10, 09)

<="" a="">Rapid Micro Biosystems (Bedford, MA)

Rapid Micro Biosystems (Bedford, MA; no SBIR) has signed a deal with the Biomedical Advanced Research and Development Authority (BARDA) that could net up to $6.7 million for the microbial contamination detection firm. The contract calls for the development of rapid sterility testing for vaccines. ...  raised an $18.6 million Series A round of financing in July 2009  [Mass High Tech, Sep 22, 10]

Rapid Micro Biosystems (Bedford, MA; no SBIR) microbial contamination detection firm, has landed an investment of $18.6 million in a Series A round  [Mass High Tech, Jul 8, 09]

<="" a="">Rapiscan (Torrance, CA)

Demand for Rapiscan (Torrance, CA; one SBIR in 1993) products, which include airport metal detectors and larger machines used to scan cargo containers and trucks, is growing as governments all over the world increase their security efforts.  Rapiscan's cargo scanning business has doubled annually for the past three years, said Peter Kant, the company's vice president of global government affairs. And the company has signed more contracts with government agencies. ... offices in Singapore, Malaysia and Australia.  At the 30,600-square-foot Apex , NC facility, Rapiscan will build larger machines capable of checking for dangerous materials in cargo containers, trucks and other vehicles. ...  2007 revenue was $186.6 million, SEC filings from its parent company, OSI Systems, show. [Raleigh News&Observer, Mar 22]

<="" a="">Raser Technologies (Provo, UT)

Within six months of discovering an enormous geothermal field, a small Utah company had erected and fired up a power plant — an example of the speed with which companies are capitalizing on state mandates for alternative energy. Anticipation of new energy policies has sparked a rush on land leases as companies such as Raser Technologies (Provo, UT; no SBIR) lock up property that hold geothermal fields and potentially huge profits. [Paul Foy, AP, Dec 26] 

<="" a=""> Raydiance

THE DISRUPTION: Lasers that cut without heating surrounding material. THE DISRUPTED: The entire laser industry - medicine, aerospace and beyond. [Barry Schuler, former CEO of AOL] two-year-old startup, Raydiance, is taking aim at the $3 billion medical laser market with a technology called USP, or ultrashort pulse.  Why? Because USP lasers are phenomenally accurate.... USP devices have been in the hands of researchers since 1989, but they've also been unmanageably large and notoriously difficult to operate. Schuler's company, funded to the tune of $35 M, has already shrunk its device to the size of a microwave oven. [Business 2.0]  Why would medical laser capital flow so readily to an AOL founder? Because capital seeks entrepreneurs who know how to use it. Sweetness of the technology is a second consideration after a real entrepreneur puts up some of his money. The SBIR [theoretical] idea that capital- inspired commercialization will follow from government buying what government likes contradicts the real world of investing. If SBIR wants substantial economic spinoff, it has to look for entrepreneurs with new ideas, not just smart technicians. Oh sure, if you spend enough money on technicians, something will come out, but not enough to justify the government spending.

<="" a="">Receptor Logic

From the Texas Emerging Technology Fund, Image Trends (Austin, TX; no SBIR) which develops image correction and enhancement products for commercial and amateur photographers will receive $1 million, and RFMicron (Austin, TX; no SBIR) $250,000 to speed development of its microchip technology  [Lori Hawkins, Austin American-Statesman, Jul 14, 08]  Og ten central TX companies fed from the fund, only one has failed so far: Nanocoolers (no SBIR) Tried to create a thermoelectric cooling system that would help cool semiconductors. Closed in 2007. The others: Molecular Imprints Inc. Nanotechnology company that makes advanced equipment used in producing computer chips, disk  drives and other products. Monebo Technologies (no SBIR) Heart monitoring device called CardioBelt that enables users to obtain their own electrocardiogram while at home.  Quantum Logic Devices  ($1+M SBIR, moved from NC) Developing a system that uses single-electron devices to analyze  DNA, protein and other molecular interactions. Receptor Logic Ltd. (no SBIR) Developing antibodies to improve understanding of the immune system and lead to better drugs and vaccines. Xitronix(no SBIR) Developing advanced semiconductor testing technology. XTreme Power (no SBIR) Developing electrical storage systems that are used to cut energy bills for commercial and industrial plants.

Two Austin companies will share $3.7 million in grants from the Texas Emerging Technology Fund, which was created to spur commercialization of research in Texas. Receptor Logic Ltd. will receive $2 million to advance its work in the development of anti-bodies that can improve the understanding of the immune system and thus lead to better drugs and vaccines.  Terapio Inc. will receive $1.7 million to develop a cream to treat hand-foot syndrome, a painful swelling and numbness of the hands and feet that can occur as a side effect of several chemotherapy drugs.  Receptor was started in 2004 by Emergent Technologies Inc., an Austin-based life sciences venture capital firm, and Jon Weidanz, director of the Texas Tech University Center for Immunotherapeutic Research. The company, which has headquarters in Austin and a laboratory in Abilene, will use the investment to expand its commercialization efforts  [Lori Hawkins, Austin American-Statesman, Jun 19] Neither had SBIR.

<="" a="">Receptos (San Diego, CA)

Receptos  (San Diego, CA; no SBIR), which is using the structure of cellular G protein-coupled receptors to develop drug candidates for autoimmune therapies, has secured $10.8 million in a funding round that could be as much as $50 million, according to a recent regulatory filing. The biopharmaceutical startup raised about $25 million in a Series A round in 2009  [Bruce Bigelow, xconomy.com, Feb 23, 12]

Receptos (San Diego, CA; no SBIR) said that it will collaborate with pharmaceutical giant Eli Lilly to develop therapies that act on certain protein receptors involved in cellular response. The companies will work on discovering orally administered drug candidates and move them through preclinical testing, Receptos said. The effort will focus on G protein-coupled receptors, a major class of targets for new drugs.  [Keith Darce, signonsandiego,com, Jan 6, 11]

<="" a="">Recodagen

things are looking better: the research-oriented startups seem poised to survive the downturn, and long-awaited clinical results could propel larger companies like Dendreon to stardom. ...  despite the financial crisis, the Accelerator, a local incubator based in Seattle's Eastlake neighborhood, created three firms last year - Recodagen, GPC-Rx and Mirina (none had SBIR) ... "Seattle is really a town of development-stage biotechs," Miller said. ... Light Sciences Oncology (no SBIR), a firm that canceled its initial public offering last February, managed to raise $10 million from venture capitalists in July. Private investors provided Redmond-based Healionics (no SBIR) — which manufactures material for implants — with a $2.6 million boost in December.  In a deal that could yield big results, Bothell-based Acucela (no SBIR), which is developing therapies to treat blindness, signed a partnership deal in September with Japanese firm Otsuka Pharmaceutical that could potentially bring it $258 million.   [Angel Gonzalez, Seattle Times, Jan 25]

Local biotech incubator Accelerator is hatching its seventh firm — Recodagen (no SBIR), which will research therapies to arrest the spread of cancerous tumors. The technology underpinning Recodagen was licensed out of the laboratory of J. Suzanne Lindsey at Washington State University in Pullman. ...  Accelerator's first technology-licensing deal with Washington State University, which in the past three years has been ramping up its efforts to get its research into the marketplace. [Angel Gonzalez, Seattle Times, Mar 14]

<="" a="">Recombinetics (Minneapolis,MN)

<="" a="">ReconRobotics  (Edina, MN)

ReconRobotics (Edina, MN; no SBIR) received another multi-million contract with the Army for its micro-robot technology.  ...  $13.9 million to produce and deliver up to 1,000 miniature, throwable mobile robots.  [Evelina Smirnitskaya, Minneapolis / St Paul Business JounrL, Jun 28, 12]

ReconRobotics (Edina, MN) specializing in microrobot technology, said its opening international headquarters in Lugano, Switzerland. [Minneapolis / St Paul Business Journal, May 30, 12]

ReconRobotics (Edina, MN; no SBIR) said it has acquired Xollai, (St. Paul, MN; no SBIR) that develops systems to help military drones land. ReconRobotics makes throwable microrobots for the military, ...  a spokesman for ReconRobotics, said Xollai's St. Paul office will remain open and all nine of its employees will stay with the company. ReconRobotics now has 54 employees, Klobucar said. [Ed Stych, Minneapolis / St Paul Business Journal, Apr 4, 12]

ReconRobotics (Edina, MN; no SBIR). has sold more of its throwable robot kits to the U.S. military — this time to the Marine Corps.  [Minneapolis / St Paul Business Journal, Mar 13, 12]

ReconRobotics (Edina, MN; no SBIR) recently raised $1.4 million from investors  ... developing scout robots used by the U.S. military and FBI, is looking for another $2.5 million.  [Thomas Lee's Patent_pending blog, Minneapolis Star Tribune, Sep 14, 09]

ReconRobotics (Edina, MN; no SBIR), which makes mini remote-control robots for military and police reconnaissance work, has raised $1.5 million in add-on financing from current investors. ... complete the company’s most recent $4 million round of equity financing.  [Sam Black, Minneapolis/St Paul Business Journal, Sep 11, 09]

<="" a="">Regado Biosciences (Durham, NC)

Regado Biosciences  (Basking Ridge, NJ; one SBIR), a drug-development company whose technology was invented at Duke University, recently raised new funding that will see it through the bulk of next year. ...  The company, which is developing several blood thinners, isn't saying how much money it raised. CEO David Mazzo said that the new funding is an extension of the $40 million round of financing it completed in December 2009. ... The company's leading experimental drug, REG1, is an anti-coagulant aimed for use during angioplasty and stent implants.  [David Ranii, Raleigh News & Observer, Jul 2, 11]

Regado Biosciences (Durham, NC; one SBIR) raised $23M from VCs to continue testing a drug that promises to make heart surgery safer. [Raleigh News & Observer, Mar 27]

<="" a="">ReGen Biologics (Franklin Lakes, NJ)

The FDA announced its intention to rescind a 510(k) medical device registration held by ReGen Biologics (Hackensack, NJ; $400K SBIR) for the company’s Menaflex collagen scaffold. The FDA granted marketing approval for the product in 2008. However, on Oct. 14, 2010, the FDA notified the company that it intended to rescind prior clearance, stating, “The FDA has now concluded that the Menaflex device is intended to be used for different purposes and is technologically dissimilar from devices already on the market” and that “these differences can affect the safety and effectiveness of the Menaflex device. For example, instead of simply repairing or reinforcing damaged tissue like predicate devices, Menaflex is intended to stimulate the growth of new tissue to replace tissue that was surgically removed. Because of these differences, the Menaflex device should not have been cleared by the agency.” [JM Garvey, Mass High Tech, Jan 18, 11]

[FDA] panel of outside experts found that there isn’t enough scientific evidence to come to a firm conclusion about the benefits of a knee device approved by the FDA in 2008. ...  cited inadequate and low-quality evidence about the effectiveness of the Menaflex implant made by ReGen Biologics (Franklin Lakes, NJ; four Phase 1 SBIRs in mid 1990s), and not enough information about the device’s safety.  [Alicia Mundy, Wall Street Journal, Mar 24, 10]

The FDA said that four New Jersey congressmen and its own former commissioner unduly influenced the process that led to its decision last year to approve a patch for injured knees, an approval it is now revisiting.  ..  The agency’s scientific reviewers repeatedly and unanimously over many years decided that the device, known as Menaflex and manufactured by ReGen Biologics (Franklin Lakes, NJ; $400K SBIR a decade ago), was unsafe because the device often failed, forcing patients to get another operation. But after receiving what an F.D.A. report described as “extreme,” “unusual” and persistent pressure from four Democrats from New Jersey ... agency managers overruled the scientists and approved the device for sale in December.  [Gardiner Harris and David Halbfinger, New York Times, Sep 25, 09]

The recent approval of a new device to treat knee injuries followed a lobbying campaign that overcame repeated rejections by scientists within the FDA, agency documents show. The FDA's internal dissent over Menaflex, which targets the most-common knee injury afflicting everyone from high-school athletes to baby boomers, is straining a government agency that oversees a quarter of the U.S. economy. Some senior FDA staff members complained in documents that the handling of Menaflex, made by ReGen Biologics (Franklin Lakes, NJ; $400K SBIR)., shows how political and industry pressure can influence scientific conclusions. [Alicia Mundy,   [Wall Street Journal, Mar 6]

<="" a="">Regenerative Sciences (Broomfield, CO)

A U.S. federal court has found that a stem cell therapy offered by a Colorado clinic is a regulated drug. The ruling could spur a U.S. Food and Drug Administration (FDA) crackdown on other clinics offering untested adult stem cell treatments. Regenerative Sciences (Broomfield, CO; no SBIR) uses stem cells extracted from a patient’s own bone marrow to treat bone and joint injuries. The company calls its treatment a medical procedure. But in a 2010 suit, FDA argued that because the stem cells are more
than “minimally manipulated” and the procedure uses reagents that cross state lines, the cells are an FDA-regulated biological drug.  [Science, Aug 3]

<="" a="">Regulus Therapeutics

Regulus Therapeutics (San Diego, CA; no SBIR, fiounded 2007) has filed [for IPO] ...   focuses on microRNA, a biotechnology specialty area. RNA, or ribonucleic acid, was only discovered about a dozen years ago. It’s considered important because RNA can influence an entire network of genes. With diseases, RNA doesn’t act normally. So by targeting RNA strands, biotech researchers may be onto a new way to treat certain ailments.Regulus is currently working on therapies for several diseases including kidney fibrosis, hepatitis C, cancer and cardiovascular diseases. Long-time San Diego biotech entrepreneur Kleanthis Xanthopoulos is the company’s chief executive and president  ... has formed some heavyweight strategic alliances with pharmaceutical giants AstraZeneca, Sanofi and GlaxoSmithKline, who have provided a combined $56.6 million in upfront research funding.  Regulus, which spun out of Isis Pharmaceuticals and Alnylam Pharmaceuticals, also has raised an additional $50 million from founders and other investors.   .[Mike Freeman, utsandiego.com, Aug 22, 12]

Regulus Therapeutics (Carlsbad, CA; no SBIR) landed an investment of at least $35 million for drug discovery and development from French pharmaceutical giant Sanofi-Aventis, with the initial work targeting fibrosis.  The development alliance has a potential value of $750 million if certain milestones are met, making it the largest partnership in Regulus’ biotechnology specialty, known as microRNA. .... 45 employees, was founded by Isis Pharmaceuticals and Alnylam Pharmaceuticals. The companies each put about $20 million into Regulus, then stocked its staff and board with some of the leading experts in the microRNA field, Simeonidis said.  [Mike Freeman, signonsandiego.com, Jun 23, 10]

Alnylam Pharmaceuticals said it was one of two firms that invested a collective total of $20 million in Regulus Therapeutics (no SBIR) ... In 2007, Alnylam and Isis Pharmaceuticals established Regulus to "focus on the discovery, development, and commercialization of microRNA-based therapeutics," the two companies said in a press release.  [Boston Globe, Mar 5, 09].

Repligen  up 12%  [Sep 10, 12]

Repligen up 16%  [Aug 2, 12]

Repligen down 10%  [Jun 22, 12]  said federal regulators have requested additional clinical trial data for their proposed imaging agent that is designed to improve detection of pancreas problems.[Boston Globe]

Repligen down 40% [Apr 26, 12]  said it expects U.S. health regulators to reject its imaging agent to detect structural abnormalities in the pancreas [Reuters]

Repligen up 11% [Jan 25, 12]

Repligen  said it has completed the acquisition of the business of Novozymes Biopharma Sweden AB, the Swedish unit of Novozymes Biopharma. The all-cash transaction, which was announced in October, had Repligen making an upfront payment of $22.7 million.
[Chris Reidy, Boston Globe, Dec 21, 11]

Repligen  said  that it has a definitive agreement to buy the biopharma business of Novozymes A/S (Sweden) in a cash transaction of 17 million euros ($22.7 million) and future potential milestone payments of 4 million euros ($5.6 million) ....   includes a 45,000-square-foot protein factory that will double Repligen’s manufacturing capacity and established product lines with long-term customers. The products include various forms of Protein A, which is fundamental to the production of monoclonal antibodies and growth factor products used in the large-scale fermentation of cells.  [Mass High Tech, Oct 28, 11]

Repligen said today that the[FDA]  has granted Fast Track status to its potential treatment for spinal muscular atrophy  [Boston Globe, Jun 23, 11]

Repligen down 28% [Mar 7, 11] after it said Monday that a midstage clinical trial showed that one of its drug candidates was no more effective than a placebo in treating bipolar depression.  [AP, Mar 7]

Repligen has taken in $1.4 million in Muscular Dystrophy Association (MDA) funding to aid research in a treatment for Spinal Muscular Atrophy (SMA). [Mass High Tech, Dec 15, 10]

Repligen has received three grants, totalling in excess of $6 million, to apply to its HDAC inhibitor research for neurodegenerative diseases like Friedreich’s Ataxia and Huntington’s Disease. [Mass High Tech, Aug 3, 10]

Repligen up 10% [May 27, 10]

Repligen  said that the FDA has granted orphan drug designation to RG2833, the company's investigational drug to treat Friedreich's ataxia. [Boston Globe, May 24, 10]

Repilgen  up 14% [Mar 31, 10]

Repligen said today that it extended its long-term deal to supply recombinant protein A to General Electric's GE Healthcare unit. [AP, Jan 28, 10]

Repligen won a $731,000 Muscular Dystrophy Association research grant to development treatment for Friedreich’s ataxia, a rare neurodegenerative disease. The grant is the second such funding from the MDA for the disease. [Mass High Tech, Dec 15, 09]

Replegen down 16% [Dec 9, 09] said that its pancreas imaging agent RG1068 did not meet its main goal in a late-stage clinical study. [Boston Globe, Dec 9]

Repligen  down 10% [Dec 1, 08]  On a stock bloodbath day

Repligen up 13% [Oct 16, 08]

Repligen down 16% [Oct 15, 08]

Repligen  up 18% [Oct 10, 08]

Biopharmaceutical Repligen got $1.125 million in research grants to develop tools to help create new treatments for the rare neurodegenerative disease Friedreich’s ataxia. The Muscular Dystrophy Association awarded Waltham-based Repligen (Nasdaq: RGEN) $1 million and the Friedreich’s Ataxia Research Foundation and the National Ataxia Foundation combined to give $125,000, according to Repligen officials. Repligen will use the funds to develop and prepare drug candidates for clinical trials and also develop biomarkers to monitor the effect of the drugs.  [Mass High Tech, Sep 4, 08]

Repligen up 14% after it reached a settlement in its lawsuit alleging patent infringement against large-cap Bristol-Myers Squibb's rheumatoid-arthritis treatment Orencia.  [Wall Street Journal, Apr 9, 08]

Repligen up 11% [Apr 4, 08]

Repligen said it has started a Phase 3 clinical trial to evaluate an imaging agent that would help MRI tests better detect abnormalities in the ducts of the pancreas. ... about 150,000 pancreatic MRI's are conducted in the United States each year. [Boston Globe, Mar 27, 08]

Repligen down 12% [Feb 25, 08]

Repligen down 12% [Jan 4, 08]

Repligen got a $65 M settlement from ImClone Systems on a patent infringement lawsuit . [Mass High Tech, Sep 11]

Repligen jumped 25% on a favorable patent-suit ruling. [Jul 31, 06]

Repligen took a huge dive (42%) when it announced that its experimental treatment for autism flunked late-stage clinical trial, second-quarter revenue of $1.4 million, sells several drugs which it did not develop itself.

<="" a=""> Research Frontiers (Woodbury, NJ)

Smart Glass  One company seems to have solved the problem of making smart windows that shut out sunlight on command. DOD has poured a lot of SBIR money into small companies who always seem to need another award. Research Frontiers Inc (Woodbury, NY) seems to have succeeded without any SBIR help.  A Wall Street Journal story (Sep 19) tells how. It went public in 1986 to raise the money (investors will speculate) for the suspended particle technology. Says CEO Robert Saxe, it wasn't an overnight technology . Which should partially explain why SBIR wasn't the route. SBIR was not intended for such long slogs (although no Congressman would object to a long slog by a company in his district and all Congress would like to avoid answering such questions). Oh, the technology seemed to work but on closer examination of the economics, it was unstable, the crystals clumped, and the windows bulged. One materialist estimates that it would cost $15/sqft more than drapes and curtains which translates to a ten-year recovery period. How many landlords accept ten-year payback periods? (Actually, the lower the prevailing interest rate, the longer the max acceptable payback period.) So, government agencies, keep believing in smart window technology, but don't blindly believe the company's story about commercialization.

<="" a="">Resolvyx Pharmaceuticals (Bedford, MA)

Resolvyx Pharmaceuticals (Bedford, MA; no SBIR) said it has initiated a clinical trial to evaluate a drug candidate for dry-eye syndrome, which affects an estimated 25 million to 35 million Americans. [Chris Reidy, Boston Globe, Dec 18]

Resolvyx Pharmaceuticals (Bedford, MA; no SBIR) hopes to use recent scientific research on how omega-3 fatty acids work to develop a powerful new class of drugs to treat inflammatory diseases, ranging from asthma to cardiovascular problems. ... is expected to say it has raised $25 M in a second round of venture capital ..in addition to an earlier round of $17M.  [Todd Wallack, Boston Globe, Apr 22]

<="" a="">Respicardia (Minnetonka, MN)

<="" a="">Response Genetics (Los Angeles, CA)

Response Genetics (Los Angeles, CA; no SBIR, 40 employees) signed a nonexclusive license agreement with GlaxoSmithKline, which grants the pharmaceutical company some rights to Response Genetics's technology that assess gene mutations in tumor samples.  [Wall Street Journal, May 12]

<="" a="">Restoration Robotics

Dr. Frederic H. Moll, 56, is a soft-spoken man who can look uncomfortable on stage. Yet his role in founding Intuitive Surgical ($2.5M SBIR), the company that now dominates the field, and his current involvement with three other robotics companies, has kept him in the sights of investors, health care providers and fellow entrepreneurs.  ... He took the idea to his employer, Guidant, a medical device company. Guidant decided that robotic surgery was too futuristic and too risky, so Dr. Moll rounded up backers, resigned, and in 1995, founded Intuitive Surgical. [which] earned $144M last year on sales of $600M .... He’s now best known as chief executive of Hansen Medical  (no SBIR), a publicly traded robotics company focused on minimally invasive cardiac care. But he’s also an investor in and a board member of Mako Surgical (no SBIR), an orthopedics robotics company that recently went public, and he is a co-founder and chairman of Restoration Robotics (no SBIR), a start-up company focused on cosmetic surgery. [Barnaby Feder, New York Times, May 4]

<="" a=""> Restore Medical

Medtronic agreed to acquire Restore Medical (Roseville,MN; one SBIR) for $29 million, a deal that rescues the cash-starved company from possible insolvency from cash management problems. [Minneapolis Star Tribune, Apr 23, 08]

Restore Medical took a 12% sleeping aid [Mar 1, 07] as it reported a big loss and got a brokerage downgrade.

Rethink Robotics

<="" a="">Retriever Technology (Santa Fe, NM)

Los Alamos National Laboratory has approved $250,000 in new funding for four companies from its Venture Acceleration Fund [which] provides investments of up to $100,000 to regional entrepreneurs, companies, investors or strategic partners who use LANL technology or expertise to create or grow regional businesses. Award recipients are chosen based on potential for regional impact, team composition, technical feasibility, market opportunity, and the availability of matching funds or in-kind contributions. Retriever Technology (Santa Fe, NM; no SBIR) will receive $25,000 to upgrade a low-light imaging camera for advanced digital imaging into a more user-friendly and functional form for customer demonstration and evaluation.  Elemetric Instruments (Los Alamos, NM; no SBIR) will get $100,000 to further develop a prototype of an instrument that immediately detects elements in liquids and gases with continuous online, real-time processing. The device, called an element presence detector, is based on LANL technology with potential markets among food and pharmaceutical makers.  STAR Cryoelectronics (Santa Fe, NM; $2M SBIR) will get $75,000 to accelerate development of a high-resolution alpha particle spectrometer to be used in nuclear forensics and nuclear nonproliferation work.  Veezyon (somewhere, NM; no SBIR) will receive $50,000 to improve the technical capabilities of its Veezyon.com Web site — a knowledge-based online video site focusing on shared interest user collaboration.  Since the venture fund was launched in fall 2006, LANL has awarded about $600,000 to six companies, not including the new grants, [New Mexico Business Weekly, Jan 7, 09]

<="" a="">Reva Medical (San Diego, CA)

Reva Medical (San Diego, CA; one SBIR) says its stock is expected to begin trading tomorrow on the Australian Securities Exchange after the medical device company raised almost $85 million in its IPO  .... will use the proceeds to continue development of its absorbable ReZolve stent, including clinical trials.  [Bruce Bigelow, signonsandiego.com, Dec 22, 10]

Reva Medical  (San Diego, CA; one SBIR)  which is developing bioabsorbable stents for treating arterial disease, has filed for a $63 million IPO on the Australian Stock Exchange, according to PE Hub. Inteq Ltd., a boutique investment bank in Sydney, is serving as the lead underwriter. The company has raised about $57 million in venture capital funding  [Bruce Bigelow, signonsandiego.com, Sep 8, 10]

Reva Medical (San Diego, CA; one SBIR) plans to raise $63 million through an IPO to fund tests of its experimental coronary stent that is absorbed by the body over time.  [Keith Darcé, San Diego Union Tribune, Aug 19, 10]

<="" a="">Revegen (Farmington, CT)

Six start-up technology firms have received grants as part of the state's small-business incubator program,  ... administered by the Connecticut Center for Advanced Technology ...  $32,000 to $50,000 went to: AllerQuest LLC of West Hartford, Catelectric Corp. of Storrs, Hydrogen Safety of East Hartford, Quadra-Aerrow International of Glastonbury, Revegen Inc. of Farmington and the Center for Network Centric Product Support Research of East Hartford.  [Hartford Courant, Dec 12, 08]  no SBIR for any

<="" a="">ReVision Therapeutics (San Diego, CA)

ReVision Therapeutics (San Diego, CA) biopharmaceutical startup, formed just five months ago to resume development of a compound for treating age-related macular degeneration, has reported encouraging results from a two-year, mid-stage clinical trial of the compound, known as fenretinide. ...  The deal to acquire the compound and start ReVision means fenretinide has come full circle. It was initially under development as a potential treatment for macular degeneration by Sytera (San Diego, CA; no SBIR) founded in 2004. But development of the drug moved to Sirion Therapeutics (Tampa, FL; no SBIR), an ophthalmic-focused biopharmaceutical that acquired fenretinide through its 2006 merger with Sytera. Sirion conducted the mid-stage clinical trials at a number of sites throughout Florida, and Lichter says the last patient left the trial in April.  [Bruce Bigelow, signonsandiego.com, Sep 18, 10]

<="" a="">ReVolt Tech

ARPA-E Awards. The administration announced $106M in ARPA-E stimulus awards. Small biz winners:  Ginkgo BioWorks (Boston, MA; one SBIR) $6M primary;  OPX Biotech (no SBIR) $6M primary; Logos Tech (Arlington, VA; $2M SBIR) secondary; Sion Power (Tucson, AZ; $250K SBIR) $5M primary; ReVolt Tech (no SBIR) $5M primary; PolyPlus Battery (Berkeley, CA; one SBIR) $5M; Pellion Tech (no SBIR) $3.2M primary; A123 Systems  secondary, twice;  Planar Energy Devices (no SBIR) $4M; Maxpower (Harleysville, PA; $9M SBIR) secondary; NanoLab (Newton, MA; $5M SBIR) secondary; Codexis (no SBIR) $4.6M; Nexant (no SBIR) secondary.

<="" a="">Rexahn Pharmaceuticals (Rockville, MD)

Rexahn Pharmaceuticals (Rockville, MD; no SBIR) sold common stock to institutional investors, generating gross proceeds of $5 million.... developing drugs for cancer, nervous system disorders and sexual dysfunction. [Washington Business Journal, Oct 26, 09] Shares trade under a buck.

<="" a=""> RF Code (Austin, TX)

RF Code (Austin, TX; no SBIR) got $13M VC part of which pays for moving from AZ to TX where it will make RFID devices to track people and stuff. [Austin American-Statesman, Jul 19] The Navy had an SBIR RFID poster child a decade ago in Savi Technology which Lockheed-Martin bought for $400M.

<="" a="">RFMicron (Austin, TX)

When startup FireFly LED Lighting (Austin, TX; no SBIR) was accepted into the Austin Technology Incubator two years ago, its LED bulbs were still prototypes.  Since then, the company has launched its product line, signed customers including Kerbey Lane Cafe and the University of Texas and received $3.4 million from backers including the Central Texas Angel Network and the Texas Emerging Technology Fund.....  Since its founding in 1989 by legendary business leader George Kozmetsky, ATI has worked with more than 200 startups, helping them raise nearly $1 billion in investment capital.  [Lori Hawkins, Austin American Statesman, Jan 26, 12]  Graduates: Agile Planet,  Atomometrics, Axelo, Calxeda, Dorsan Biofuels, Famigo, GameSalad, Ideal Power Converters, Itzbig, Nitero, Notice Technologies, Open Algae, Qcue, RFMicron, RRE Solar,  Savara Pharmaceuticals, Spredfast, Terapio ($500K  SBIR), Unwired Nation, WiMax.com. 

From the Texas Emerging Technology Fund, Image Trends (Austin, TX; no SBIR) which develops image correction and enhancement products for commercial and amateur photographers will receive $1 million, and RFMicron (Austin, TX; no SBIR) $250,000 to speed development of its microchip technology  [Lori Hawkins, Austin American-Statesman, Jul 14, 08]  Og ten central TX companies fed from the fund, only one has failed so far: Nanocoolers (no SBIR) Tried to create a thermoelectric cooling system that would help cool semiconductors. Closed in 2007. The others: Molecular Imprints Inc. Nanotechnology company that makes advanced equipment used in producing computer chips, disk  drives and other products. Monebo Technologies (no SBIR) Heart monitoring device called CardioBelt that enables users to obtain their own electrocardiogram while at home.  Quantum Logic Devices  ($1+M SBIR, moved from NC) Developing a system that uses single-electron devices to analyze  DNA, protein and other molecular interactions. Receptor Logic Ltd. (no SBIR) Developing antibodies to improve understanding of the immune system and lead to better drugs and vaccines. Xitronix(no SBIR) Developing advanced semiconductor testing technology. XTreme Power (no SBIR) Developing electrical storage systems that are used to cut energy bills for commercial and industrial plants.

<="" a=""> RF Surgical (Bellevue, WA)

<="" a=""> Rhenium Alloys (Elyria, OH)

Balls - An 11th Form of Rhenium. Rhenium Alloys (Elyria, OH) which sells ten forms of rhenium got a BMDO Phase 2 SBIR for an 11th form: micro-spheres. The immediate use for BMDO is coating small rocket nozzles that have to pass really hot gas. There may be a little puffery going on as the company invites present orders for the balls that BMDO says it is only nursing into existence as a prototype. It's the company's first Phase 2. Neither the abstract nor  Rhenium's website hint at the economic value of the spheres beyond cost-insensitive military rockets.

<="" a=""> Rhevision

Ben Choi, one of the In-Q-Tel guys, told us yesterday he's just made an investment into Rhevision Technology, which is making a miniature zoom lens for cameras. Its Website is still under construction, but the company says modestly that the lens module is "going to rock the entire camera-phone industry."  [Siliconbeat.com, May 5]

<="" a=""> Rho (Chapel Hill, NC)

Rho (Chapel Hill, NC; $2M SBIR) a drug research company, received a $38.9 million contract from  NIH ...  provide biostatistical, data management and safety services to the Immune Tolerance Network ... founded in 1984 by two UNC-Chapel Hill researchers. The company now employs about 350 [Raleigh News & Observer, Sep 5, 08]

<="" a=""> Rhythm (also Rhythm Pharmaceuticals (Boston, MA)

Rhythm (Boston, MA;  no SBIR) biotechnology company focused on diabetes and obesity, announced that it has raised $25 million in a Series B financing round. ...  brings the total capital raised to $65 million. ... said it will use the proceeds to continue advancing its small-peptide therapeutics for metabolic diseases through Phase 2 clinical trials. [Chris Reidy, Boston Globe, Jun 13, 12]

Rhythm Pharmaceuticals (Boston, MA; no SBIR), a virtual life sciences company making peptide-based drugs to treat conditions such as obesity and diabetes, has launched with a $21 million Series A round ... has licensed intellectual property from French pharmaceutical Ipsen SA  [Mass High Tech, Mar 15, 10]

<="" a=""> Rhythmia Medical (Burlington, MA)

Rhythmia Medical (Burlington, MA; at least $200K SBIR) has taken in $2.7 million in an equity round [says an SEC filing] ... had raised $12 million since its founding in 2004   [Mass High Tech, Mar 19, 10]

<="" a="">Rib-X Pharmaceuticals (New Haven, CT)

Rib-X Pharma going IPO tomorrow to raise about $70M with Deutsche Bank as lead. will be highly speculative and any reward will be years in the making. ...  has also received a letter from its independent financial auditing firm expressing doubts about whether Rib-X will be financially able to continue its business. Additionally, in its S1, Rib-X states that the cash from the IPO is still not enough to complete a phase 3 trial of Delafloxacin.  [seekingalpha.com, May 7]

Rib-X Pharmaceuticals  scored a $3 million milestone payment from French biotech giant Sanofi related to a license for the New Haven, Conn.-based company’s antibiotics to fight superbugs. .... To date, Rib-X has taken in $22 million through four milestone payments, and it could receive as much as $740 million from the [July 2011] deal.   [Michelle Lang, Mass High Tech, Feb 7, 12]

Rib-X Pharmaceuticals (New Haven, CT; $1.1M SBIR) drug development firm co-founded by Yale Nobel laureate, intends to raise as much as $80 million in an[IPO] ... with 43 employees, is developing several antibiotics, notably Delafloxacin, which is in clinical trials and is intended for the treatment of "acute bacterial skin and skin structure infections," primarily in hospitals.  [Dan Haar, Hartford Courant, Nov 29, 11]

Rib-X Pharmaceuticals (New Haven, CT; $1.1M SBIR) has taken in $5.5 million of a planned $22 million offering combining debt, warrants and options  [Michelle Lang, Mass High Tech, Jan 28, 11]

Rib-X Pharmaceuticals (New Haven, CT; $1.1M SBIR), an antibiotics company has taken in a $20 million financing ...  to help bring its delafloxacin antibiotic drug to a Phase 2b study this year  [Michelle Lang, Mass High Tech, Jan 11, 11]

Rib-X Pharmaceuticals (New Haven, CT; $1M SBIR) antibiotics company raised $5.5 million of a planned $15 million offering of debt and warrants, according to [SEC] filing ... founded in 2001 by Yale University colleagues Peter Moore, William Jorgensen and Thomas Steitz, winner of a portion of the 2009 Nobel Prize in Chemistry for his work describing the structure and function of the ribosome. ... On its website, Rib-X notes that it has raised more than $123 million in three [VC] rounds.  [Michelle Lang, Mass High Tech, Jun 11, 10]

Rib-X Pharmaceuticals (New Haven, CT; $1M SBIR) co-founder and Yale University professor Thomas Steitz has won a share of the 2009 Nobel Prize in Chemistry for his work describing the structure and function of the ribosome, according to the school. Steitz, a professor of molecular biophysics, biochemistry and chemistry, will share the $1 million prize [three ways]  [Mass High Tech, Oct 7, 09]

<="" a=""> Ridgetop Group (Tucson, AZ)

<="" a=""> RipCode (Austin TX)

RipCode (Austin TX; no SBIR) unveils today a powerful but compact box that takes up a small slot in a computer data center but does the video processing work of 10 to 20 servers. [Kirk Ladendorf, Austin American-Statesman, Sep 17]

<="" a="">Rive Technology (Cambridge, MA)

Rive Technology (Cambridge, MA;  no SBIR) announced the closing of a $25 million round of financing. ...  seeks to commercialize catalyst technology for petroleum refining. Rive's proprietary technology, invented at the Massachusetts Institute of Technology, makes traditional zeolite refining catalysts more accessible to hydrocarbon molecules  [Boston Globe, Dec 14, 10]

In an effort to make gasoline production cleaner and more efficient, Rive Technology (Cambridge, MA; no SBIR) is developing a catalyst that can help turn a greater percentage of crude petroleum into gasoline and other usable products. ... could increase the proportion of petroleum processed by as much as 7 to 9 percent. ...  Javier Martinez, a cofounder of Rive and now a professor at the University of Alicante, in Spain, came up with a way to control the size of the openings while working as a postdoctoral fellow at MIT's Nanostructured Materials Research Laboratory.   [Neil Savage, MIT Tech Review, Jul 10, 09]  has raised $22 million in venture capital   [company website]

<="" a=""> RJA Dispersions

Aldevon (Fargo, ND; no SBIR), maker of DNA and protein products is putting a research and sales operation in [Wisconsin] ....  founded by two ND State U graduates, has more than 70 employees, and provides products and services to pharmaceutical companies and diagnostic test-makers.  ... also welcomed to Wisconsin: RJA Dispersions (no SBIR), VitalMedix (no SBIR) and Rapid Diagnostek (no SBIR), from Minnesota; Flex Biomedical (one SBIR) and Exact Sciences (no SBIR), from Massachusetts; NanoMedex ($1M SBIR), from Florida; and Inviragen ($2M SBIR) from Colorado. Biotechnology is the fastest-growing segment of the Wisconsin economy, with an annualized growth rate of nearly 7%, [Gov] Doyle said in a statement. The sector has 400 companies in the state with 34,000 employees.

<="" a=""> R.L. Phillips (Carlsbad, CA)

Information security firm R.L. Phillips (Carlsbad, CA; no SBIR) is being bought by a Michigan firm for $2.2M.  Phillips, founded in 1998 by James Pietrocini and Rebecca Phillips, generated about $5.3 M in annual revenue. It has about 30 employees and serves customers that include the Navy, the Marine Corps and the NSA. [San Diego Union Tribune, Sep 6]

<="" a="">RMH Sciences (Philadelphia, PA)

BioAdvance, operator of the Biotechnology Greenhouse Corp. of Southeastern Pennsylvania, said it made commitments of $2.4 million to seven new life science companies:  RMH Sciences  (Philadelphia, PA; no SBIR) which is developing antibacterial agents for the treatment of resistant gram negative and gram positive infections; Ossianix  (no SBIR), which is developing single domain antibodies based on the shark VNAR structure to treat immunological, inflammatory, musculoskeletal, neurologic, and other disorders; Merganser Biotech (Newtown Square, PA; no SBIR) which is developing hepcidin peptides for the treatment of hemoglobinopathies such as sickle cell anemia and diseases of iron overload; Anakim Biologics (Exton, PA; no SBIR) which is developing efficiencies and improvements in biologics manufacturing; Enzium (Philadelphia, PA; no SBIR) which is developing highly sensitive biosensor methodologies for the testing of proteases and other enzymes; Imiplex (Newtown, PA; two SBIRs) which is developing the TriPol platform, engineered from proteins, designed to provide a flexible system for constructing diverse nanostructures; Cool-Bio (Wayne, PA; no SBIR) which is developing platelet-inhibiting technology geared specifically to activation during the cooling process of cardiac bypass.  [John George, Philadelphia Business Journal, Jun 20, 12]

<="" a="">Robopsy (Cambridge,MA)

After several years of development, startup Robopsy (Cambridge, MA; no SBIR) is entering the home stretch in its quest to get to market with its disposable robotic diagnosis devices. ...  technology was jointly developed by experts at Massachusetts General Hospital and MIT. Since Robopsy first launched several years ago, the system has gone through two prototypes, explained co-founder Rajiv Gupta, MGH laboratory director for the department of radiology  [Marc Songini, Mass High Tech, May 1, 09]

<="" a=""> Robotic FX

Robotic FX will be dissolved and certain of its residual assets will be retained by iRobot, according to the company. [Founder and ex-iRobot employee] Ahed has been prohibited from participating in competitive activities in the robotics industry for five years.  [Mass High Tech, Dec 24]

A federal judge in Boston has issued an injunction against a Chicago-area robot maker accused of stealing trade secrets from iRobot [Boston Globe, Nov 3, 07]   Defendant Robotic FX was not reported as railing against "activist un-elected judges."

<="" a="">Robotic Technology (Potomac, MD)

The Energetically Autonomous Tactical Robot is known, of course, by its acronym: EATR. It is the brainchild of Robotic Technology  (Potomac, MD; $900K SBIR) ....  could, for instance, forage for biofuel while an [Army] unit on a long-endurance mission rested. It could then be used to recharge their electrical devices, carry some of their equipment or even transport the soldiers. ...  Robert Finkelstein, Robotic Technology’s president, estimates that about 68 kilograms (150 pounds) of vegetation would provide enough electricity for the machine to travel around 160km (100 miles).  [The Economist, Jun 12, 10]

<="" a="">Rocky Research (Boulder City, NV)

Rocky's Cooler. A refrigerator with no compressor would come from the sorption system of Rocky Research (Boulder City, NV), says Design News, (Nov 4, 96). BMDO SBIR's support was matched in part by investment from Igloo Products during which the technology was the basis for a new FMC Corp factory in Arkansas. Look for ever more portable coolers with the Igloo label if and when Rocky can raise the ever rising capital needed by a maturing technology. BMDO's invitation of matching the early capital brought in Igloo's first investment but government's role ends there (unless you believe in programs like ATP which let companies avoid the discipline of the marketplace and appeal, instead, to the technology preferences of government experts).

RRE Solar (TX)

<="" a="">Rules-Based Medicine (Austin TX)

Rules-Based Medicine (Austin, TX; $2M SBIR)  filed to raise $90 million in a public stock offering in 2010 ...  founded in 2002, has developed technology for tests that identify biomarkers that can signal whether a patient has a particular disease or disorder and how well drugs are working. [Austin American Statesman, Dec 24, 09]

Rules-Based Medicine (Austin TX; one SBIR) got a $1.1M Phase I/Phase II "Fast-Track" SBIR from the National Cancer Institute for the development of 50 new quantitative, multiplexed immunoassays for cancer-related proteins . It calls itself the world’s leading multiplexed biomarker testing company [company press release]

<="" a="">Rushford Hypersonic

NanoReturn. Will any of this stuff translate into an economic windfall for Minnesota? So far, the U has licensed nanotechnology to three companies, two of them local, with mixed results.  Nanocopoeia (St. Paul , MN; $1M SBIR) is trying to divest its original medical device coating business to focus on pharmaceuticals. Rushford Hypersonic (no SBIR) next month will open the world's first hypersonic plasma particle disposition plant in southeastern Minnesota. Innovalight, (Austin, TX to St. Paul, MN to Sunnyvale, CA; $900K SBIR in TX), which originally focused on light bulbs, is now making solar cells. ...  The U's uneven experience with nanoscience mirrors corporate America's teasing and often frustrating flirtation with a technology that's failed, so far, to match hype with reality. Despite millions of dollars in government research money and venture capital, making big bucks off nanotechnology remains an elusive dream. [Thomas Lee, Minneapolis Star Tribune, Jun 28, 09]  Nanostuff, GaAs, CVD diamond, SiC substrates, and such, are the kind of futures that SBIR should invest in until economic barriers show that it has only a long term possible future. Then it should be turned over to long term investors with long green, not slogged away in a small high tech nursery program. SBIR's goal should be economic visibility for a technology, not long term development a few bucks at a time in life-style companies.

<="" a="">RXi Pharmaceuticals (Worcester, MA)