The Department of Energy has awarded $53 million [of SBIR] to multiple small businesses to develop clean energy materials and systems in support of the Biden administration’s net-zero emission goals. Proposals include a lithium-ion electric vehicle battery from Bioenno Tech (Santa Ana, CA; $4M prior SBIR), a bio-based composite material from Z&STech (no apparent SBIR) and a direct air capture system from Advanced Cooling Technologies (Lancaster, PA; $80M prior SBIR; competitor in same city,Thermacore; $32M prior SBIR). ... Charles River Analytics (Cambridge, MA; $270M SBIR) proposed a method to detect an attack on critical infrastructure assets such as power grid, while Cornerstone Research Group (Miamisburg, OH; $127M prior SBIR) offered a predictive health monitoring tool to maintain electric grid systems. [Mary-Louise Hoffman, govconwire.com, May 19, 2022] prior SBIR data from SBA
NeuroMetrix (Woburn, MA; $600K SBIR) up 76% [May 19, 22]
Dynavax Tech (Berkeley, CA; $6.3M SBIR) up 16% [May 19, 22]
Caribou Biosciences (Berkeley, CA; $300K SBIR) up 22% [May 12, 22] announced initial results demonstrating a 100% overall response rate (ORR) and 80% complete response rate (CR) in cohort 1 (n=5 evaluable) from its ANTLER Phase 1 trial for CB-010 in patients with relapsed or refractory B cell non-Hodgkin lymphoma (r/r B-NHL). [company press release, May 12, 2022]
FibroGen (SOUTH SAN FRANCISCO, CA; $1.1M SBIR) up 26% [May 10, 22]
a Defense Department study found China is exploiting a popular program that funds innovation among small American companies. The study, which was viewed by The Wall Street Journal, found China is using state-sponsored methods to target companies that have received Pentagon funding from [SBIR]. ..... Some in Congress are now echoing those calls, as lawmakers seek a five-year reauthorization of the SBIR and a related STTR, as part of a sweeping, bipartisan legislative package working its way through Capitol Hill. [Kate O'Keeffe, Wall Street Journal, May 9, 22]
Intelligence community venture capital firm In-Q-Tel has made an investment in Fortify (Boston, MA; $1.2M SBIR) to help further develop its 3D printing technology for use in electronics design and production. [Mary-Louise Hoffman, govconwire.com, Apr 28, 22]
Protagonist Therapeutics (Newark, CA; $3.3M SBIR) down 50% [Apr 26, 22] announced topline results from the Phase 2 IDEAL study evaluating PN-943 in patients with moderate-to-severe ulcerative colitis (UC). [company press release, Apr 25, 22]
Immucell (Portland ME; $2.5M SBIR) up 29% [Apr 25, 22]
Switchblade drones, made by AeroVironment (Monrovia,CA; $25M SBIR), were designed to attack either soldiers or tanks. But the technology is versatile: Larger versions can take out artillery tubes, crater runways and destroy radar installations. Smaller versions can target the drivers of vehicles, or individual officers if they are detected. [Julian E. Barnes, NY Times, Apr 22. 22]
Innovative Scientific Solutions (Dayton, OH; $50M SBIR) won a potential $184.3 million contract from the Air Force Research Laboratory to study combustion and propulsion technologies for potential defense use. ISSI will carry out research work under the indefinite-delivery/indefinite- quantity contract at Wright-Patterson AF Base in Ohio and will receive $842,500 in incremental funds for the first task order, the Department of Defense said. [Angeline Leishman, govconwire.com, Apr 22, 22]
Protagonist Therapeutics (Newark CA; $3.2M SBIR) down 22% [Apr 22]
Crinetics Pharmaceuticals (Encinitas, CA; $10M SBIR) up 24% [Apr 13, 22] announced the pricing of an underwritten follow-on offering of 5,625,563 shares of its common stock at a price to the public of $22.22 per share. [company press release, Apr 13, 22]
BioCryst Pharmaceuticals up 15% [Apr 13, 22]
Lyra Therapeutics (Watertown, MA; $6.3M SBIR) up 22% [Apr 8, 22] announced that it has entered into a securities purchase agreement to sell securities in a private placement that is expected to result in gross proceeds of approximately $100.5 million, before deducting offering expenses. [company press release, Apr 8, 22]
Adaptive Phage Therapeutics {Gaithersburg, MA; $300K SBIR) announced that the AMR Action Fund has joined an existing $41 million Series B round as a co-investor. [company press release, Apr 4, 22]
BioCryst Pharmaceuticals (Durham NC; ) down 38% [Apr 8, 22] announced that the company has paused enrollment in clinical trials with BCX9930 while the company investigates elevated serum creatinine levels seen in some patients. [company press release, Apr 8, 22]
Arzeda (Seattle, WA; $3.5M SBIR) the industry-leading Protein Design Company™, announced today that it has closed a $33 million investment, in a Series B round of funding. [company press release, Mar 30, 22]
Longeveron (Miami, FL; $5.2M SBIR) down 18% [Apr 4, 22]
Momentus (Los Angeles CA; one SBIR) up 48% [Apr 6, 22]
SAB Biotherapeutics (Sioux Falls, SD; $3M SBIR) a clinical-stage biopharmaceutical company with a novel immunotherapy platform that produces specifically targeted, high-potency, fully-human polyclonal antibodies without the need for human donors, reported that due to low hospitalization and death rates in the trial, the National Institutes of Health’s (NIH) ACTIV-2 Program is discontinuing enrollment in its Phase 3 COVID-19 trial. [company ress release, Mar 2, 2022]
Biogen and Ionis Pharmaceuticals are axing their partnered ALS med after it failed to show any benefit in a phase 1 trial. [Max Bayer, FierceBiotech, Mar 28, 2022]
Immunogen ($2.3M SBIR)'s phase 3 ADC survival data spook investors. While the biotech is racing to the FDA with the results, its stock fell around 20% after the release of survival data. [Nick Paul Taylor, Fierce Biotech, Mar 21, 2022]
Sarcos Technology and Robotics has agreed to acquire RE2 (Pittsburgh, PA; $22M SBIR), a developer of mobile robotic systems and autonomy software, for approximately $100 million in cash and stock. The two companies aim to offer a suite of technology products powered by artificial intelligence, machine learning, computer vision and autonomous technologies, according to a joint statement [govconwire.com, Mar 29, 22]
A Northwestern University spinout has hauled in more funding from the Department of Defense for its technology that makes stronger lithium-ion batteries. NanoGraf announced Monday that it won a $1M development contract from DoD to create a longer-lasting battery for the Army. The stronger battery will be used to improve the communication equipment used by soldiers in the field, the company said. U.S. soldiers have as much as 20 pounds of lithium-ion batteries in their equipment, which powers things like helmets, goggles and other communication devices, NanoGraf said. A stronger battery can reduce that weight and improve the efficiency of their equipment. It's the second award NanoGraf has received from the DoD. In 2020 it got a $1.65M grant, and the following year it developed what the company said is the world’s longest-running 3.8Ah lithium-ion cell. NanoGraf's new cell, a 4.3Ah lithium-ion battery, is expected to be ready by 2024. Founded in 2012 and formerly known as SiNode Systems, NanoGraf's technology was initially developed at Northwestern University and Argonne National Laboratory. The startup was founded by Samir Mayekar, who is now Chicago's deputy mayor for economic and neighborhood development. NanoGraf is led today by CEO Francis Wang. [Jim Dallke,Chicago Inno, Mar 28, 2022]
Arcadia Biosciences ($9M SBIR) down 17% [Mar 25, 22]
Alexion Pharma (Cheshire, CT; $1.8M SBIR), a subsidiary of AstraZeneca, entered into a settlement agreement with Chugai Pharmaceutical Co., Ltd. (Chugai), resolving all patent disputes between the two companies related to Ultomiris (ravulizumab). [AstraZeneca press release, Mar 17, 22]
RightHand Robotics (Somerville, MA; $1M SBIR) announces that it has secured $66 million in a Series C financing led by top growth investors [company press release, Feb 23, 22]
Karyopharm Therapeutics down 28% [Feb 22, 22]
Karyopharm Therapeutics (Newton, MA; $2.2M SBIR) up 20% [Feb 18, 22]
nLight Photonics (Camas, WA; $15M SBIR) down 19% [Feb 18, 22]
Baebies (Morrisville, NC; $22M SBIR) has [further] raised nearly $12 million [Zac Ezzone, Triangle Inno, February 22, 2022]
Cytokinetics announced topline results from METEORIC-HF (Multicenter Exercise Tolerance Evaluation of Omecamtiv Mecarbil Related to Increased Contractility in Heart Failure) [in which] There was no effect on the primary endpoint, which was the change in peak oxygen uptake (pVO2) on CPET from baseline to Week 20 in patients treated with omecamtiv mecarbil compared to placebo. [company press release, Feb 15, 2022]
ImmunoGen (Cambridge, MA; $1.6M SBIR) announced a global, multi-year definitive licensing agreement whereby it granted Eli Lilly and Company (Lilly) exclusive rights to research, develop, and commercialize ADCs directed to targets selected by Lilly based on ImmunoGen's novel camptothecin technology. ImmunoGen retains full rights to the camptothecin platform for all targets not covered by the Lilly license. As part of the agreement, Lilly will pay ImmunoGen an upfront payment of $13 million, reflecting initial targets selected by Lilly. Lilly may select a pre-specified number of additional targets, with ImmunoGen eligible to receive an additional $32.5 million in exercise fees if Lilly licenses the full number of targets. ImmunoGen is eligible to receive up to $1.7 billion in potential target program exercise fees and milestone payments based on the achievement of pre-specified development, regulatory, and commercial milestones. [Immunogen press release, Feb 15, 2022]
Dexcom ($3M SBIR) bests its 'best year ever' with 27% surge to $2.5B revenue in 2021 [Fierce Biotech, Andrea Park, Feb 11, 2022]
SBIR programs of the National Institutes of Health (NIH) supported the development of 99 drugs from 1996-2020 — a total that includes 16 percent of all such treatments that made a “significant” advance over available medicines. This finding is just one of the impacts that the National Academies of Sciences, Engineering and Medicine (NASEM) attributes to the program in a new report [SSTI, Feb 16, 22]
Brass. Former President Donald Trump said in a court filing Monday that he "denies knowledge or information sufficient to form a belief as to the truth" about his company's finances. A day later, he issued a blistering 1,100-word statement [as he] waxed lyrical about his company's "fantastic assets" and said prosecutors should give consider giving Hillary Clinton the death penalty instead of investigating the Trump Organization's finances. [Yahoo News Feb 17, 2022]
BioDelivery Sciences International up 53% [Feb 14, 22] on buyout report
Aperiomics (Sterling, VA; $900K SBIR) sold its technology, which pinpoints causes of unsuccessfully diagnosed infections, to industry giant Labcorp in late 2021. [DCInno, Feb 15, 2022]
R stands for Royalty? Today, the erstwhile “party of ideas” offers none beyond 2020 election conspiracy theories, culture war grievances and, of course, undying fealty to Trump. Recall that, for the first time since its founding more than 160 years earlier, the GOP released no platform ahead of the 2020 election. Instead the Republican National Committee proffered a blank-check pledge to support whatever it was Trump might wish to do. {Catherine Rampell, WashPost, Feb 14, 2022]
BioDelivery Sciences (Newark, NJ; $1.9M SBIR) announced that it has entered into a definitive merger agreement for Collegium Pharmaceutical, to purchase all outstanding shares of BDSI [for] approximately $604 million [company press release, Feb 14, 22]
Labcorp, a leading global life sciences company, announced that it has entered into a definitive agreement to acquire Personal Genome Diagnostics (PGDx), (Baltimore MD; $900K SBIR) a leader in cancer genomic with a portfolio of comprehensive liquid biopsy tissue-based products. ... Labcorp will pay $450M in cash at closing and up to an additional $125 million on achieving future performance milestones [Labcorp press release, Dec 23, 2021]
Epirus {Los Angeles, CA; $250K SBIR, founded 2018) announced their solution to the problem [of drone swarms]: a microwave-emitting pod that can sit on the bottom of heavy-lift drones and quickly down sudden drone swarms. [DefOne, Feb 14, 22] a startup company that develops directed energy systems and is working with General Dynamics to add counter-unmanned aerial system capabilities to Strykers, has a technology platform that brings high power density and efficiency, according to the AAL release. [breakingdefense.com, Jan 30, 22]
Also Army Futures Command awards Spark Thermionics (Emeryville, CA; $3.3M SBIR] to develop innovative power solutions for the service. [breakingdefense.com, Jan 30, 22]
Also Army Futures Command awards Xerion Advanced Battery (Westminster, CO; $15M SBIR) to develop innovative power solutions for the service. [breakingdefense.com, Jan 30, 22]
Venture capitalists can brag about their failures, but bureaucrats are flayed for them. [Ezra Klein, NY Times, Feb 14, 22] Why SBIR has not achieved much. Anyway the restrictions on government snooping on private firms' finances prevent any economic judgment on the return to SBIR "investment".
Synaptogenix (Newark, NJ; $1M SBIR) up 29% [Feb 1, 22] develops a product platform based upon a drug candidate called bryostatin for the treatment of Alzheimer’s disease, which is in the clinical testing stage [company web site]
Financially troubled biotech Marrone Bio Innovations [Davis, CA; $600K SBIR a decade ago) has never made a profit in its nearly 16-years of operations. Now, the company has moved its corporate headquarters from Davis to Raleigh, North Carolina in what officials say is a plan to be closer to international agricultural markets and finally get into the black. [Randy Diamond, Sacramento Bee, Dec 7, 21]
Applied Spectra (West Sacramento, CA; $6M SBIR) awarded $1.3 million [more] SBIR to develop uses for its laser ablation technology, which can be used for chemical analysis while affecting only a tiny bit of material. [Mark Anderson, Sacramento Inno, December 23, 2021]
Valley Tech Systems (Folsom, CA; $22M SBIR) awarded a subcontract worth up to $94 million for base and future option scope by Lockheed Martin for an advanced solid-propulsion subsystem for its Next Generation Interceptor (NGI) contract with the U.S. Missile Defense Agency (MDA). [company press release, Dec 7, 21]
Venture capitalists say a reset in investment behavior is starting to take hold, a change that they say is poised to reduce initial public offerings, leave some companies short of funding and crimp valuations. [Eliot Brown and Heather Somerville, Wall Street Journal, Feb 2, 22]
in Mr. Jones’s telling, a “communications revolution,” as the printing press prefigured the cellphone’s disturbing power to disrupt and re-create access to information that reshapes an entire world. [Maureen Quilligan reviewing Powers and Thrones: A New History of the Middle Ages by Dan Jones, WSJ, Feb 2, 22]
Give me liberty or give me death [any proud-to-be-a-Republican]. Cumulative U.S. Covid-19 deaths per capita are highest among other large, high-income countries. Several countries had higher per capita Covid-19 deathsearlier in the pandemic, but the U.S. death toll now exceeds that of peer nations. [Benjamin Mueller and Eleanor Lutz, NY Times, Feb 2, 22]
Atom Computing (Berkeley, CA; $1M SBIR in Cary, NC) has raised $60 million. [company press release, Jan 25, 2022] Last year, Atom unveiled a 100-qubit quantum computer with a coherence time of 40 seconds. [Raleigh News & Observer, Jan 22, 2022]
Sarepta Therapeutics the leader in precision genetic medicine for rare diseases, and GenEdit (Berkeley, CA; $200K SBIR), a developer of genetic medicines that leverage its NanoGalaxyTM polymer nanoparticle platform for tissue-selective delivery, announced a research collaboration and option agreement under which the companies are employing GenEdit’s NanoGalaxy platform and Sarepta’s gene editing technology to develop gene editing therapeutics for the treatment of neuromuscular diseases.In addition to research payments, under the terms of the collaboration and option agreement, GenEdit may receive up to $57 million in near-term payments and is also eligible for significant future development, regulatory and commercial milestones [joint companies press release, Feb 1, 2022]
A big chunk of Pfizer’s plan to add $15 billion to sales just went up in smoke. Having gone over phase 2b data on cardiovascular drug vupanorsen, Pfizer has decided to return the rights to Ionis Pharmaceuticals, leaving it without a candidate it tipped to deliver peak sales of more than $3 billion. Pfizer paid Ionis $250 million upfront for vupanorsen in 2019 [Nick Paul Taylor, Fierce Biotech, Jan 31, 2022]
Capricor Therapeutics (San Diego, CA; $5.3M SBIR) announced that it has entered into a partnership with Nippon Shinyaku Co (Japan) for the exclusive commercialization and distribution in the United States of Capricor’s lead asset, CAP-1002, for the treatment of Duchenne muscular dystrophy (DMD), a rare neuromuscular disease with limited treatment options. ... Capricor will receive an upfront payment of $30 million with potential additional milestone payments of up to $705 million. [Capricor press release, Jan 25, 2022]
Vantage Robotics (San Leandro, CA; $1M SBIR), a speciality drone maker, recently announced plans to bring an undisclosed number of jobs to Ohio, after JobsOhio helped incentivize the expansion through its Growth Capital program. Officials from both Vantage Robotics and JobsOhio declined to share the value of that incentive. [Meg Erpenbeck, CincyInno, Jan 27, 2022]
Vascudyne (Stillwater, MN; no SBIR) [UM spinoff] startup that's developing a new replacement for heart valves and veins, has raised $10 million in a Series A round [ Carter Jones, MinneInno, Dec 6, 21]
Avivomed (Minneapolis, MN; no SBIR) medical device company, announced the completion of a Series A Preferred Stock financing of $32 million. ... The company said in a statement a "world-class syndicate of medical device investors" were involved in the round that will allow the company to develop neuromodulation technology that will treat patients suffering from chronic diseases. [company press release, Dec 1, 21]
Faeth Therapeutics (San Francisco, CA; no SBIR) raised $20 million in a seed round. founded to translate breakthrough discoveries, made by world-leading cancer research laboratories into clinical practice. The startup is converging precision therapeutics, software, and nutrition to treat cancer. Precise nutritional interventions are delivered to the patient at home, with AI-guided software [Emma Betuel, TechCrunch, Jan 26, 22]
Curi Bio (Seattle, WA; $4.5M SBIR) announced the second closing of a $10 million oversubscribed Series A financing [company press release, Dec 29, 2021]
NeuroMetrix (Woburn, MA; $600K SBIR in 1985) after announcing that the FDA granted the Breakthrough Designation for its Quell technology designed to address symptoms in chemotherapy-induced peripheral neuropathy (CIPN). Under the designation, NeuroMetrix is entitled to priority review and more interactive communications with the regulator during the development of the device. [Seeking Alpha, Jan 18, 22]
SinnovaTek (Raleigh, NC, $200K SBIR, founded 2015) developed a food processing approach that helps address vitamin deficiency among children living in Africa. The company is a Phase III success, having successfully developed and sold its processing systems. [SBA news letter Jan 20, 2022] company website promises good stuff but provides no financial info, one of the barriers for anyone trying to evaluate SBIR as an economic entity and not just a government handout program
E-stethoscope developer Strados Labs (Philadelphia, PA; one SBIR) raises $4.5M pre-Series A round ... RESP is the company's platform technology for wirelessly and remotely monitoring patient lung sounds and patterns anywhere and at any time. [John George, Philadelphia, Inno, Jan 5, 2022]
Forward Edge-AI (San Antonio, TX; $1.2M SBIR) received [unstated amount) funding from Microsoft Corp. for Blaise, the company's handheld device, which is designed to detect pathogens on hard surfaces, [said] CEO Eric Adolphe. Microsoft (NASDAQ: MSFT) provided this funding through its Black Partner Growth Initiative [Jeannette E. Garcia, San Antonio Inno, Dec 10, 2021]
Right-wing platforms are one-trick ponies. They’re only going to, by their nature, appeal to the type of person they are branded to appeal to, and there’s only so many people in that world. [Jeremy B. Merrill and Drew Harwell quoting Darren Linvill, the lead researcher at Clemson University’s Media Forensics Hub, WashPost, Jan 20, 2022]
there’s no guarantee that if a company’s AI could gauge an emotion it wouldn’t exploit it; when standing at the intersection of data and well-being, Big Tech does not necessarily take the high road. [Steven Zeitchik, WashPost, Jan 17, 2022]
Sarepta Therapeutics is walking away from a partnered gene therapy just months before the readout of a pivotal clinical trial. The biotech stuck with Lysogene {France) through a tough 2020 that featured the death of a child who received their partnered gene therapy but has now decided to exit the deal. Sarepta paid Lysogene $15 million for ex-Europe rights to a gene therapy against the neurodegenerative lysosomal storage disorder mucopolysaccharidosis type IIIA in 2018 as part of its push into the modality. [Nick Paul Taylor, Fierce Biotech, Jan 13, 22]
Daiichi Sankyo is shutting down (PDF) its Plexxikon (South San Francisco, CA; $300K SBIR in 2003) R&D operation in South San Francisco. More than 10 years after buying the biotech for $805 million upfront, Daiichi has decided to drop the 60-employee operation to focus investment on three antibody-drug conjugates (ADCs). [Nick Paul Taylor, Fierce Biotech, Jan 12, 22]
Regeneron and 2seventy bio 9no SBIR) have revealed the candidate spearheading their CAR-T pact. Working with the bluebird bio spinout, Regeneron has selected MUC16 as the target for the first CAR-based solid tumor program. Bluebird and Regeneron began working together on oncology cell therapies in 2018. [Nick Paul Taylor, Fierce Biotech, Jan 11, 22]
Moderna is doling out a little bit of its COVID-19 vaccine cash in a $45 million oncology research deal with Carisma Therapeutics (Philadelphia, PA, no SBIR) to pick up to a dozen targets for development and commercialization. [Annalee Armstrong, Fierce Biotech, Jan 10, 22]
Cancer test maker Exact Sciences will invest $350 million to grow its Madison campus with a new research and development facility as well as an expansion of an existing laboratory and warehouse space. [Wisconsin Inno, Jan 13, 22]
Bone Biologics (Burlington, MA; one SBIR in 2005) up 57% [Dec 10, 22]
BioCryst Pharmaceuticals up 28% [Jan 10, 22] announced financial results and forecast
Wisconsin [Center for Technology Commercialization, Jan 10, 2022] reorts that Wisconsin is passing out state funded supplements to SBIR awardees. The Phase 1 recipients, each receiving up to $75,000 match, are:
The Phase 2 recipients, each receiving up to $100,000 match, are:
The U.S. is planning to hand out $10 billion to help upstart companies gain access to capital in a bid to rev up business in disadvantaged communities and spur a broader economic recovery from the pandemic. The State Small Business Credit Initiative will direct money to states, territories and tribal governments for programs that provide venture capital or encourage private lenders to issue loans to small firms. [Wall St Journal, Jan 10, 22] The political lure of fair-share handouts to small biz.
News as mere entertainment. perhaps, the network will simply rely on its past defense of Carlson: that viewers should know better than to assume that he’s presenting factual information. [Philip Bump, WashPost, Jan 11, 22]
Cytokinetics (South San Francisco, CA; $500K SBIR) and Royalty Pharma plc announced that Cytokinetics has secured long-term capital from Royalty Pharma to support the potential commercialization of omecamtiv mecarbil and the further development of aficamten. In addition, Cytokinetics sold to Royalty Pharma royalties on future worldwide sales of aficamten. Royalty Pharma will provide Cytokinetics long-term capital of up to $300 million to support the potential commercialization of omecamtiv mecarbil and the further development of aficamten, and other general corporate purposes. The capital is available in five tranches, including an initial tranche of $50 million upon closing and four additional tranches in the aggregate amount of $250 million upon the occurrence of certain regulatory and clinical development milestones related to omecamtiv mecarbil and aficamten. In addition, Royalty Pharma has purchased from Cytokinetics a royalty on aficamten of 4.5% on sales up to $1 billion and 3.5% on sales above $1 billion, [joimt companies press release, Jan 7, 2022]
Sanofi is rethinking its approach to genomic medicines. Having worked with Sangamo Therapeutics on personalized cell therapies, Sanofi has decided to scrap the deal and shift its focus to allogeneic universal genomic medicine approaches. The termination of the deal, which is set to take effect in June, will return full control of sickle cell disease candidate SAR445136 to Sangamo. [ Nick Paul Taylor, Fierce Biotech, Jan 6, 22]
VLP Therapeutics (Gaithersburg, MD; $300K SBIR) vaccine developer raised $21 million in a Series A-1 funding round ... to accelerate research and development of a cancer treatment vaccine, the company said, in addition to preventative malaria and dengue vaccines. [Ana Lucía Murillo, DCInno, Dec 27, 21]
Annexon (Brisbane, CA; $1.4M SBIR) down 34% [Jan 5, 22] announced interim data from its ongoing, open-label Phase 2 clinical trial of ANX005 in patients with Huntington’s disease (HD) who completed the 24-week treatment period. Annexon is developing ANX005, its lead monoclonal antibody candidate, for the treatment of a range of complement-mediated disorders, including HD. [company press release, Jan 4, 22]
Dying for the cause. conservatives framed all Covid precautionary measures as violations of individual freedom. Dying for your beliefs has taken on grim new meaning: Since vaccines became widely available, counties that voted heavily for Donald Trump have had nearly three times the Covid-19 death rate as counties that voted for Joe Biden. [Rebecca Solnit, NYTimes, Jan 4, 22]
Voltaire: “Those who can make you believe absurdities can make you commit atrocities.” [quoted by Jennifer Szalai reviewing How Civil Wars Start by Barbara Walter, NY Times, Jan 3, 22]
Rhaeos (Evanston, IL; $1.2M SBIR) raised $2.2M in a seed round. .... has raised more than $8M in total funding since it was founded in 2018. [Jim Dallke, ChicagoInno, Dec 28, 21]
Personal Genome Diagnostics (Baltimore, MD; $900K SBIR) has agreed to be acquired by [Labcorp] one of the world's largest life sciences companies in a deal that could pay up to $575 million. [Holden Wilen, Baltimore Inno, Dec 23, 21]
Awash in capital. Investors are defying a share-price slump for newly public companies to make hundreds of billions of dollars available to startups, a cash pile that promises to inject a torrent of money into early-stage firms in 2022 and beyond. [Amrith Ramkumar and Eliot Brown, Wall Street Journal, Dec 28, 21] Thus undercutting the rationale for SBIR of a shortage of capital for new small high tech firms. But a government handout once established will surely continue anyway.
Cytokinetics has found another company that still sees a future for its heart fai lure prospect omecamtiv mecarbil. After losing partnerships with Amgen and Servier in quick succession, Cytokinetics has sold the Chinese rights to the candidate to Ji Xing Pharmaceuticals. [Nick Paul Taylor, Fierce Biotech, Dec 22, 21]
Kebotix (Cambridge, MA; $200K SBIR) a technology platform company for new chemicals and materials, has been selected as the industry partner of a new $15-million interdisciplinary research institute led by Colorado School of Mines and funded by the National Science Foundation. [company press release, Sept. 28, 2021]
Galera (Malvern, PA; $1.1M SBIR) announced that corrected results from its Phase 3 ROMAN trial of avasopasem for the treatment of RT-induced severe oral mucositis (SOM) in patients with locally advanced head and neck cancer (HNC) achieved statistical significance on the primary endpoint of reduction in the incidence of SOM. Avasopasem has been granted Breakthrough Therapy Designation (BTD) by [FDA] for the reduction of SOM induced by RT. [company press release, Dec 14, 21]
Robotic Research (Clarksburg, MD; $23M SBIR) secured its first outside investment in a $228 million Series A funding round, company executives said ... develops comprehensive autonomous driving technology that can be deployed on commercial, bus and logistics vehicles. [company press release, Dec 10, 21]
Nanochon (Washington, DC; $200K SBIR) just got a step closer in its quest to get a 3D-printed implant to market — thanks to $2 million in fresh funding and the potential to raise more. [company press release, Dec 10, 21]
IsoPlexis (Wilmington, DE; $17M SBIR) up 41% [Dec 20, 21]
CytomX Therapeutics (Santa Barbara, CA; $500K SBIR) down 40% [Dec 21, 21] announced preliminary Phase 2 results in patients with either advanced squamous non-small cell lung cancer (sqNSCLC) or head and neck squamous cell carcinoma (HNSCC), who were treated with CX-2029 -- a CD71-directed conditionally activated antibody-drug conjugate (ADC) being co-developed by CytomX and AbbVie. [company press release, Dec 20, 21]
ACADIA Pharmaceuticals (San Diego, CA; $1.6M SBIR) down 20% [Dec 21, 21] announced that it plans to resubmit its supplemental New Drug Application (sNDA) for pimavanserin for the treatment of hallucinations and delusions associated with dementia focused on Alzheimer's disease psychosis (ADP). Resubmission of the sNDA to [FDA] is planned for the first quarter of 2022. [company press release, Dec 21, 21]
Quantum Diamond Technologies (Somerville, MA; $1.7M SBIR) reports A novel approach to testing for the presence of the virus that causes Covid-19 may lead to tests that are faster, less expensive, and potentially less prone to erroneous results than existing detection methods. Though the work, based on quantum effects, is still theoretical, these detectors could potentially be adapted to detect virtually any virus, the researchers say. [David L. Chandler, Massachusetts Institute of Technology Dec 20, 2021]
Novavax is finally ready to submit its application for emergency use authorization (EUA) in the U.S., and could do so as early as this week, according to CEO Stanley Erck. "We will be filing within the next few days in the U.S.," Erck said. [company press release, Dec 20, 21]
Americans’ trust in their government, their institutions, and even their fellow citizens is declining rapidly—weakening the very foundations of society. Cyberattacks prey on these weak points, sowing distrust in information, creating confusion and anxiety, and exacerbating hatred and misinformation. [Jacquelyn Schneider, Foreign Affairs, J/F22] Perhaps we could start by not electing serial liars as President and Members of Congress.
[US]Commerce’s National Institute of Standards and Technology (NIST) has awarded more than $3.5 million in [SBIR] funding to 17 U.S. small businesses for advancing technologies in manufacturing, privacy, medical diagnostics and more. [DOC announcement] All Phase 2 awardees had more than one previous SBIRs the largest collector of which was WW Technology (ELLICOTT CITY, MD) which has already had $20M SBIR in 45 awards dating from 1996 to 2020.
Cyrus Biotechnology (Seattle, WA; $200K SBIR) announced the closing of a $18M Series B financing and acquisition of Orthogonal Biologics, a deep mutational scanning protein engineering spin-out from the University of Illinois at Urbana Champaign. [company press release, Dec 6, 21]
Omeros (Seattle, WA; $5.4 M SBIR) announced is selling its Omidria franchise to the British eye care company Rayner Surgical Group Ltd. The deal includes a $125 million upfront payment and a commercial milestone payment of $200 million for Omidria, a drug that prevents excessive pupil constriction in cataract surgery. Omeros will also receive royalty payments for sales made both within and outside of the U.S. According to Omeros, the deal is valued at more than $1 billion. [company press release, Dec 6, 21]
Ensysce Biosciences (Houston, TX; $300K SBIR) up 67% [Dec 9, 21]
Context Therapeutics (Philadelphia, PA; $200K SBIR) up 25% [Dec 9, 21] announced that data from the window-of-opportunity clinical trial of onapristone extended release (ONA-XR) in postmenopausal patients with progesterone receptor positive (PR+) early breast cancer demonstrated ONA-XR significantly increased suppression of tumor cell proliferation. [company press release, Dec 9, 21]
Novavax up 29% [Dec 7, 21]
Vaxxinity (no SBIR) up 25% [Dec 7, 21]
Aerovironment down 27% [Dec 7, 21] reported financial results for its fiscal second quarter ... "While we achieved second quarter and first half results in line with our expectations, headwinds to our business have intensified in recent months, requiring us to reduce our full year outlook," said [CEO] Wahid Nawabi. [company press release, Dec 7, 21]
Cumberland Pharmaceuticals down 18% [Dec 7, 21]
Longeveron (Miami, FL; $5.2M SBIR, 12 employees) down 22% [Dec 1, 21]
Cumberland Pharmaceuticals (Nashville, TN; $4.6M SBIR) down 18% [Dec 1, 21]Cumberland Pharmaceuticals (Nashville, TN; $4.6M SBIR) up 129% [Nov 30, 21] announced [FDA] approved expanded labeling for Caldolor(R), an intravenously delivered formulation of ibuprofen, to now include use in pre-operative administration. The non-narcotic pain reliever may now be administered just prior to surgery to enable patients to wake up from their procedure in significantly less pain. [company press release, Nov 29, 21]
ImmunoGen (Waltham, MA; $1.8M SBIR in mid-1990s) up 30% [Nov 30, 21] announced positive top-line data from the pivotal SORAYA trial evaluating the safety and efficacy of mirvetuximab soravtansine (mirvetuximab) monotherapy in patients with folate receptor alpha (FR)-high platinum-resistant ovarian cancer who have been previously treated with Avastin(R) (bevacizumab). [company press release, Nov 30, 21]
Moderna up 21% [Nov 26, 21]
Longeveron (Miami, FL; $5.2M SBIR, 12 employees) down 21% [Nov 26, 21]
Semma Therapeutics (Cambridge, MA; subsidiary of Vertex Pharma, no SBIR, founded 2014) reports success with curing Type 1 diabetes with stem cell therapy. {Gina Kolata, NYTimes, Nov 27, 21]
QuEra Computing (Boston, MA; $300K SBIR) At long last, physicists from Harvard and MIT have found the killer application for quantum computing: a Mario Bros. GIF made from qubits. ... emerging from stealth, to show off the programmability of their 256-qubit quantum simulator—a special-purpose quantum computer built for solving certain types of problems. [Siobhan Roberts, MIT Tech Rvw, Nov 17, 21]
Longeveron (Miami, FL; $5.2M SBIR, 12 employees) up 146% [Nov 24, 21]
Aptevo Therapeutics (Seattle, WA; no SBIR) down 30% [Nov 24, 21]
Aptevo Therapeutics (Seattle, WA; no SBIR) up 132% [Nov 23, 21]
Longeveron (Miami, FL; $5.2M SBIR, 12 employees) down 39% [Nov 23, 21]
“There’s a joke among epidemiologists,” Brandon Dean, an emergency-response planner in the Los Angeles County Public Health Department, told me. “If you’ve seen one pandemic, you’ve seen one pandemic.” [Jeneen Interlandi, [CDC] ambitious $200 million center to predict future outbreaks, NYTimes, Nov 23, 21]
Longeveron (Miami, FL; $5.2M SBIR, 12 employees) up 181% [Nov 22, 21]
Neurocrine Biosciences (San Diego, CA; $10M SBIR) and Sosei Heptares (Japan) announce the signing of a strategic collaboration and licensing agreement to develop novel muscarinic receptor agonists, which Neurocrine Biosciences intends to study in the treatment for schizophrenia, dementia and other neuropsychiatric disorders. ... Sosei Heptares will receive a total of $100 million USD in upfront cash up to $2.6 billion USD upon achieving certain global sales milestones. [joint companies press release, Nov 22, 21]
PhaseBio had already shown its Brilinta reversal agent could work in healthy volunteers, but now the biotech has the phase 3 data to back up the therapy's use in patients who are in an emergency situation. [Emmy Lucas, Fierce Biotech, Nov 15, 2021]
Leidos' Dynetics [Huntsville, AL; $5M SBIR) subsidiary has won a $478.6 million contract from the U.S. Army to develop a thermal protection system intended to protect surface-to-surface hypersonic missiles from intense heat during flight. Dynetics will build the Hypersonic Thermal Protection System prototype and help the military branch conduct materials research, inspection and acceptance efforts under the cost-plus-fixed-fee contract, the Department of Defense said [Angeline Leishman, govconwire, Nov 22, 21]
Longeveron (Miami, FL; $5.2M SBIR, 12 employees) up 46% [Nov 19, 21]
Longeveron (Miami, FL; $5.2M SBIR, 12 employees) up 135% [Nov 18, 21] announced that [FDA] granted Rare Pediatric Disease (RPD) designation for Lomecel-B for the treatment of Hypoplastic Left Heart Syndrome (HLHS), a rare and life-threatening congenital heart defect in infants. [company press release, Nov 18, 21]
ARPA-e reports ESS Tech (Wilsonville OR; $3M SBIR, market cap $2B) went public after SBIR funding for continued development of its iron flow batteries for commercial and energy storage applications. [company website]. The only serious question is whether the government was competing with private capital that would heave invsted the same aounts if the technical risk was within usual VC boundarie. The $2B market cap a month after IPO paints a low hanging fruit question. No great surprise that govt agency and th Congresscritter wants some good publicity.
Plastomics (St. Louis, MO; $200K SBIR) biotech startup, plans to advance its crop improvement technology after raising $7.1 million. [St Louis Inno, Nathan Rubbelke, Nov 16, 2021[
Dicerna Pharmaceuticals (Lexington, MA; $5.7M SBIR) up 79% [Nov 18, 21] announced that it has entered into a definitive agreement with Novo Nordisk under which Novo Nordisk (Denmark) will acquire Dicerna, a biopharmaceutical company focused on the development of investigational ribonucleic acid interference (RNAi) therapeutics, for $38.25 per share in cash, which represents a total equity value of $3.3 billion [company press release, Nov 18, 21]
Cassava Sciences down 24% [Nov" 17, 21] [SEC] is investigating claims that Cassava Sciences [sixth-best performing US stock this year] manipulated research results of its experimental Alzheimer’s drug with the matter.[Dave Michaels and Joseph Walker, Wall Street Journal,Nov 18, 2021]
Kezar Life Sciences (South San Francisco, CA; no SBIR, 47 employees) up 35% [Nov 16, 21] reported interim results from the Phase 2 portion of its MISSION clinical trial evaluating KZR-616, a first-in-class selective immunoproteasome inhibitor, in patients with active, proliferative lupus nephritis (LN). "The MISSION Phase 2 interim results present a strong signal that KZR-616 is active and could be a meaningful therapy for patients with lupus nephritis, a long term and difficult to treat disease," said Noreen R. Henig, M.D., Kezar's Chief Medical Officer. [company press release, Nov 15, 21]
SCYNEXIS up 25% [Nov 15, 21] reported quarterly financials
Everspin Technologies (Chandler AZ; $600K SBIR) up 63% [Nov 12, 21] Reports its Best Quarter in Company History [company press release, Nov 11, 21]
Oncorus ($300K SBIR) down 45% [Nov 12, 21] presented initial safety, tolerability and immune activation and clinical response data from its ongoing Phase 1 open-label, multi-center, dose escalation and expansion clinical trial of ONCR-177 and that it has signed an exclusive licensing agreement with Gaeta Therapeutics Ltd., related to the use of locally delivered Interleukin-12 (IL-12) via oncolytic viral expression in combination with immune checkpoint inhibitors, [company press releases, Nov 11, 21]
Denial is easier. Recent climate disasters have failed to shift Americans' views on global warming, a new Washington Post-ABC News poll finds, and the partisan divide has widened. [Darryl Fears and Emily Guskin, WP, Nov 11, 21] The economic losers, the fossil fuel industry, appeals to the immediate discomfort of switching power sources from well embedded habits. And uneducated voters don't see a clear acceptable alternative.
In many states, the burden of proof has shifted from requiring defendants to demonstrate that they acted in self-defense to requiring prosecutors to show that they did not.
I’m convinced that most wealth created since 1971 is a direct result of the [Intel] 4004. All of tech. All of finance. All of retail—ask Walmart about its inventory system. ... What will we do with all this power? That question is like seeing the 4004 and being asked what microprocessors will be used for besides calculators in the future. Your answer would probably be off by a factor of a billion. [Andy Kessler, WSJ, Nov 14, 21]
PDF Solutions (Pittsburgh, PA; $1.3M SBIR) up 26% [Nov 10, 21] reported third quarte financials engages in the provision of an end-to-end analytics platform that empowers engineers and data scientists across the semiconductor ecosystem [company website]
Amyris (Emeryville, CA; $900K SBIR) own 9% [Nov 9, 21] reported financial results an d offer of $400M in senior notes [company press releases, Nov 9, 21]
Shasqi (SanFrancisco, CA; $2.9M SBIR) announced a Series B funding round of $50 million to advance the Phase 1/2 clinical study of SQ3370 for the treatment of injectable, advanced solid tumors, and will enable Shasqi to expand its click chemistry platform to create therapeutics that do not require intratumoral injections. [company pressrelease, Nov 11, 21]
PhaseBio (Malvern, PA; $3.6M SBIR) announced iachieved its primary endpoint and topline data from its Phase 2b clinical trial of bentracimab, which was conducted in healthy, older volunteers 50-80 years old. [company press release Nov 3, 21]
Biolinq (San Diego, CA; $2.2M SBIR) announced securing a hefty $100 million in investor support to kick-start the development of its wearable, noninvasive glucose sensor patch. [Conor Hale, Fierce Biotech, Nov 2, 2021]
Water will become the world’s most contested resource. [Crawford Gribben reviewing Jeremy Black's A Short History of War, WSJ Nov 10, 21]
Fuel Cell Energy up 20% [Nov 8, 21]
bluebird bio down 19% [Nov 8, 21] reported quarterly financials
ViaSat (Carlsbad, CA; $17M SBIR) agreed to purchase British satellite services provider Inmarsat for approximately $3.9 billion in cash and stock as both companies aim to offer a global hybrid network for government and enterprise communications. [Naomi Cooper, govcomwire.com, Nov 9, 2021]
IntelinAir (Champaign, IL; $500K SBIR) raised $20 million in Series B funding to continue to scale the company and its flagship crop intelligence platform, AGMRI®. [company press release, Sep 24, 21]
Deciphera Pharmaceuticals (Waltham, MA; no SBIR) down 75% [Nov 5, 21] announced top-line results from the INTRIGUE Phase 3 clinical study of QINLOCK in patients with gastrointestinal stromal tumor (GIST) previously treated with imatinib. The study did not meet the primary endpoint of improved progression-free survival (PFS) compared with the standard of care sunitinib. [company press release, Nov 5, 21]
BrainXell (Madison, WI; $3.5M SBIR) raised a $13 million Series A round last month for a $59 million post-money valuation. [Teddy Nykiel, WiscInno, October 15, 2021]
BioRestorative Therapies (Melville NY; no SBIR) down 48% [Nov 5, 21] announced the pricing of the underwritten public offering [company press release, Nov 5, 21]
Applied Optoelectronics (Sugar Land, TX; $54M SBIR) down 32% [Nov 5, 21] reported third quarter finncial resuls
Dynavax Technologies down 20% [Nov 5, 21] reported third quarter finncial results
Immuto Scientific (Madison, WI; $300K SBIR) raises $2.3 million to scale its drug discovery technology [Teddy Nykiel, WiscInno, October 12, 2021]
Semba Biosciences (Madison, WI, $1.8M SBIR) has been bought by Tosoh Bioscience LLC (King of Prussis, PA) (subsidiary of Japanese parent) in an all-cash transaction [Teddy Nykiel, WiscInno, Oct 7, 2021]
Atrophied. America is not young anymore. Whereas it was once spry and excitable, it is now creaky and soft. The country that passed Prohibition and created Social Security now spends decades dithering over how large a role the government should play in health care. The country that went to the moon shrinks at the challenges presented by climate change. Its bold and expansive political imagination has atrophied. [Ezekiel Kweku, NY Times Opinion politics editor, Jul 2, 21] The political nation has allowed total economic wealth to become the main political criterion, a judgement that favors the rich who reap the profits of such growth. As a result the proportion of the total wealth held by the rich keeps growing. Meanwhile, the inflation adjusted income of the laboring class hasn't changed for decades.
Cassava Sciences (Austin, TX; no SBIR) up 49% [Nov 4, 21] announced that it has been informed by the Journal of Neuroscience that there is no evidence of data manipulation in an article it published in July 2012 describing a new approach to treating Alzheimer's disease(1). [company press release, Nov 4, 21]
Sangamo Therapeutics up 19% [Nov 4, 21] announced preliminary results from the Phase 1/2 STAAR clinical study evaluating isaralgagene civaparvovec, or ST-920, a wholly owned gene therapy product candidate for the treatment of Fabry disease. [company press release, Nov 4, 21]
Gelsight (Waltham, MA; $900K SBIR), robotics company raised $6M [Boston Inno, Nov 3, 21]
Karyopharm Therapeutics ($2.2M SBIR) up 37% [Nov 3, 21] reported a strong third quarter, which saw a significant increase in net product revenues versus the second quarter of 2021. XPOVIO continues to move into earlier lines of therapy in multiple myeloma as a new and effective modality that can become the standard of care in second line plus where utilizing new mechanisms is critical to improve patient outcomes," said [CEO] Richard Paulson [company pres release, Nov 3, 21]
Inovio Pharma announced that it has received authorization from India's Central Drugs Standard Control Organization (CDSCO)'s Drug Controller General of India (DCGI) to proceed with the Phase 3 segment of INOVIO's global Phase 2/3 trial, INNOVATE (INOVIO INO-4800 Vaccine Trial for Efficacy), in India for INO-4800, its DNA vaccine candidate for COVID-19. INOVIO is partnering with Advaccine Biopharmaceuticals Suzhou Co., Ltd. (Advaccine) to conduct the INNOVATE Phase 3 segment in multiple countries [company press releas, Nov 3, 21]
Cassava Sciences up 26% [Nov 2, 21]
Vuzix (Rochester, NY; $250K SBIR) up 32% [Nov 1, 21] a leading supplier of Smart Glasses and Augmented Reality (AR) technology and products, is pleased to report that Newsweek has included Vuzix in their 2021 list for Most Loved Workplaces, which ranks the top 100 companies as part of a collaboration with the Best Practice Institute (BPI) [company press release, Oct 28, 21]
Novasenta (Pittsburgh. PA; no SBIR) focused on immunotherapy treatment for cancer, raised a $20 million seed round. [Patty Tascarella PittsburghInno, October 14, 2021]
Carmell Therapeutics (Pittsburgh, PA; $1.2M SBIR) raised $11M [Patty Tascarella PittsburghInno, October 14, 2021]
The United States, more than any other nation, cannot avoid the conflicts and disputes provoked by immigration. This country is not only has the most immigrants of any country in the world, it is also the first-choice destination of most potential immigrants and, possibly most confounding, it has become inextricably dependent on foreign-born workers to perform essential tasks. [Thomas Edsall, New York imes, Nov 3, 21] Like the public attitudes on taxes, they want the benefits without paying the price. And pandering politicians tell them they can have their wish.
Angion Biomedica (San Francisco, CA; $60M SBIR) down 56% [Oct 27, 21] on news that its kidney transplant hopeful ANG-3777 has failed a phase 3. [Ben Adams, Fierce Biotech, Oct 27, 2021] Federal agency using SBIR for a long term project that precludes hundreds of early innovation trials for new compnies and ideas. A problem that Congress ignores as long as the agencies spend the mandated amount on small business in this "fair share" political program.
SAB Biotherapeutics down 17% [Oct 27, 21]
Galera Therapeutics (Malvern, PA; $900K SBIR) drug for a radiotherapy complication called severe oral mucositis failed in a phase 3 trial. [Annalee Armstrong, Fierce Biotech, Oct 19, 2021]
Crinetics Pharmaceuticals (San Diego, CA; $10 SBIR) has partnered with venture capital shops to launch Radionetics Oncology with $30 million in initial fuel. While Crinetics is largely focused on oral treatments for rare endocrine diseases and related tumors, Radionetics' mandate is a much broader scope within oncology. [Kyle LaHucik, Fierce Biotech, Oct 18, 2021]
SAB Biotherapeutics (Sioux Falls, SD; $3M SBIR) up 34% [Oct 26, 21] a clinical-stage biopharmaceutical company with a novel immunotherapy platform that produces specifically targeted, high-potency, fully-human polyclonal antibodies without the need for human donors, today announced the completion of its business combination with Big Cypress Acquisition Corp, a publicly-traded special purpose acquisition company (SPAC) focused on innovative biopharmaceutical firms. [company press release, Oct 25, 21]
medical device startup ReVivo Medical (Schenectady, NY; one SBIR) said it has raised $2 million over the past year. The company’s two titanium alloy implants, which were developed in the Albany Medical Center Biomedical Acceleration and Commercialization Center, are used together to hold vertebrae in place following spinal surgeries. [Justin Dawes, October 11, 2021, Albany Inno]
Context Therapeutics (Philadelphia, PA; one SBIR) up 21% [Oct 21, 21] after IPO
Anello Photonics (Santa Clara, CA; $250K SBIR, founded 2018) which [former Intel researcher] Mario Paniccia founded, is using photonics technology to send or collect data — to make chip-based gyroscopes. Its chip is designed to replace fiber-optic gyroscopes in vehicles, drones and consumer electronics devices. Anello got an affirmation of its approach when it announced it had closed a $28 million Series A round, [Cromwell Schubarth, BayAreaInno, October 21, 2021]
Galera Therapeutics (Malvern, PA; $1.1M SBIR) down 70% [Oct 19, 21] announced results from the Phase 3 ROMAN trial of avasopasem manganese (avasopasem) for severe oral mucositis (SOM) in patients with locally advanced head and neck cancer (HNC) undergoing standard-of-care radiotherapy. The trial did not meet its primary endpoint of reduction in the incidence of SOM. [company press release, Oct 19, 21]
Omeros down 26%, [Oct 18, 21] announced that the company received a Complete Response Letter (CRL) from the U.S. Food and Drug Administration (FDA) regarding its Biologics License Application (BLA) for narsoplimab in the treatment of hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA). [company press release, Oct 18, 21]
ESS Tech (Wilsonville, OR; $2.8M SBIR] down 20% [Oct 13, 21] began trading ... ESS manufacturer of long-duration batteries for commercial and utility-scale energy storage applications, and ACON S2 Acquisition a publicly traded special purpose acquisition company, today announced the completion of their previously announced business combination (the "Business Combination"), resulting in ESS becoming a publicly listed company. [joint companies press release, Oct 11, 21]
ChemoCentryx ($100K SBIR 20 years ago) up 96% [Oct 8, 21] had slipped 68.3% this year, while the broader S&P 500 SPX, 0.14% is up 16.1%. [yahoonews, Oct 8, 21]
Semba Biosciences (Madison, WI; $1.6M SBIR) has been bought by Tosoh Bioscience LLC, one of its investors and a Pennsylvania-based subsidiary of Tokyo chemical company Tosoh Corp. [Wisconsin Inno, Oct 7, 2021]
[present] therapies are not as effective at attacking cancer cells that lack the antigen they are designed to target. Yale University spinout Cybrexa Therapeutics (New Haven, CT; $1.2M SBIR) is reporting promising early evidence indicating it may have a solution to that shortcoming. Cybrexa has developed a peptide-drug conjugate (PDC) which, instead of aiming for a specific antigen, targets the acidic environment of cancer cells to deliver a toxic payload. [Angus Liu, Fierce Biotech, Oct 7, 2021]
REGENXBIO down 20% [Oct 4, 21]
Biomerica up 38% [Oct 1, 21] announced that it has entered into a General Merchandise Supplier Agreement with Walmart for the sale of the Company's EZ Detect(TM) colorectal disease screening test within the Walmart retail system. [company press release, Oct 1, 21]
Omeros (Seattle, WA; $5M SBIR) down 38% [Oct 1, 21] announced that [FDA] notified the company that, as part of FDA's ongoing review of the company's Biologics License Application (BLA) for narsoplimab in the treatment of hematopoietic stem cell transplant associated thrombotic microangiopathy (HSCT-TMA), FDA has identified deficiencies that preclude discussion of labeling and post-marketing requirements/commitments at this time. FDA stated that the notification does not reflect a final decision on the information under review. [company press release, Oct 1, 21]
Kytopen (Cambridge, MA; $1M SBIR) a biotechnology company spun out of MIT offering a scalable technology for engineered cell therapies, today announced it has raised $30 million in an oversubscribed Series A funding. The new capital will be used to commercialize Kytopen’s Flowfect® Tx for cGMP-compliant cell therapy manufacturing and move towards treating the first human patient with Flowfect® engineered cells. [company press release, Sep 28, 21]
SAB Biotherapeutics (Sioux Falls, SD; $3M SBIR) snared another $60.5 million from the U.S. Department of Defense (DOD) to fund an antibody program to treat COVID-19. This brings the total funding SAB's received from the Biomedical Advanced Research Development Authority and the DOD to $200 million to support development of treatments for the deadly respiratory disease, according to the company’s Wednesday press release. [Annalee Armstrong, Sep 22, 2021, Fierce Bjotech]
early-stage startup Spartina Biotechnologies (Santa Fe, NM; no SBIR), uses what are called exosomes to deliver genetic material and proteins to cells in the body. This helps to combat infection. Spartina Biotechnologies' technology packages RNA, a type of genetic molecule, into exosomes. ... currently attempting to raise an investment round of $1.5 million, which will allow the company to work through pre-clinical trials. [ Collin Krabbe, New Mexico INNO, Sep 27, 21]
Zalgen Labs (Germantown, MD; $2.8M SBIR) has inked a contract with the Coalition for Epidemic Preparedness Innovations, a foundation that invests in vaccine development for emerging infectious diseases including Covid-19, to run a clinical trial in West Africa. There, it will study Lassa fever. ... CEPI plans to buy more than $750K of diagnostics from Zalgen “in the short term,” to get the trial going, [Sara Gilgore, DCInno, Sep 23, 21]
When we look to government’s role, it’s clear that driving into the future based on the realities we knew in the pre-pandemic age is like steering down a highway at 85 mph by looking in the rear-view mirror. [Donald Kettl, Government Executive, Sep 27, 2021] The Republicans representing industry management will have to side with treating labor, any labor, as a mere commodity.
NanoViricides (no SBIR) up 63% [Sep 21, 21]
NeuroMetrix up 27% [Sep 21, 21]
Competition down-under. Phillips 66 announced that it had agreed to take a 16% stake [for $150 million] in Novonix Ltd., a Brisbane, Australia-based battery materials and technology company. . [Chris Mathews, Houston Inno, Aug 9, 21]
CTI (McLean, VA) announces it has been awarded a $188M GSA FEDSIM SBIR Phase III contract: "Multi-Domain Analysis, Evaluation, and Software for Tactical and Remote Operations (MAESTRO)." MAESTRO is a multi-sponsor, combined effort for engineering services and software development to integrate SBIR technologies into existing manned and unmanned vehicles and cloud solutions, leveraging CTI's Small Business Innovative Research (SBIR) developed technology. [company press release, Sep 21, 21] Well, only post-SBIR. GSA doesn't have an SBIR program, and Phase III is not SBIR money. SBIR law does encourage post-SBIR investment by giving the federal agency some sole-source authority.
Macrogenics (Rockville, MD; $2.6M SBIR) down 24% [Sep 16, 21] announced results from Cohort A Part 1 of the Phase 2/3 MAHOGANY clinical trial of margetuximab. MARGENZA(R) (margetuximab-cmkb) is approved in HER2+ metastatic breast cancer and is being investigated as a potential first-line treatment for patients with HER2+ gastric cancer (GC) or gastroesophageal junction (GEJ) cancer in combination with a checkpoint inhibitor, with or without chemotherapy. [company press release, Sep 16, 21]
Lexeo Therapeutics (New York, NY; $3M SBIR) has raised $100 million to advance a pipeline of treatments for genetic cardiovascular and central nervous system conditions. The series B fundraising comes barely two months after Lexeo snapped up three heart disease programs through the acquisition of Stelios Therapeutics. [ Annalee Armstrong, Fierce Biotech; Sep 9, 21]
The organ-on-a-chip developer Emulate (Boston, MA; one SBIR), a leading provider of next generation in vitro models, announced the close of an $82 million Series E financing round [company press release, Sep 7, 21]
[US Navy] awarded RE2 Robotics a $9.5 million defense contract to enhance the development of RE2's Maritime Mine Neutralization System (M2NS), an autonomous underwater robotic arm and computer system capable of disabling mines or other improvised explosive devices found in deep seas or oceans. [Nate Doughty, Pittsburgh Business Jounal, September 14, 2021]
Albany Molecular Research (Albany, NY; $800K SBIR), a leading global contract research, development and manufacturing organization serving the pharmaceutical and biopharmaceutical industries, today announced that it is changing its name to Curia, effective July 12, 2021. The new name reinforces the company’s strategic positioning as an end-to-end global CDMO, applying its scientific expertise and extensive capabilities from research and development (R&D) through to commercial manufacturing to enable its pharmaceutical and biotechnology customers to advance important new products that improve lives. [company press release, Jul 12, 21] .... announced it has entered into a definitive agreement to acquire LakePharma biologics drug discovery, clinical research, development and manufacturing organization with operations in California, Massachusetts, and Texas. [company press release July 14, 2021]
Paradromics (Austin, TX; $800K SBIR), a company Bloomberg identified as a competitor to Elon Musk's Neuralink, announced it had raised $20 million in seed funding. The company makes high data rate brain-computer interfaces. [AustinInno, Jul 22, 21]
Committees have marked up their drafts for the $3.5 trillion reconciliation bill, and the proposals include multiple, significant investments that could strengthen regional innovation economies. This article identifies more than $85 billion in potential innovation-focused spending without including much of the legislation’s potential R&D investments.[SSTI, Sep 16, 2021] Sounds good to the polticians, can't do much harm, but most likely to go to companies that cannot compete in capital markets because their innovations don't look like economic winners. For a discussion of industrial policy, see https://bostonreview.net/law-justice/mariana-mazzucato-rainer-kattel-josh-ryan-collins-industrial-policy-comeback-forum?utm_source=Boston+Review+Email+Subscribers&utm_campaign=915c8ac6d6-MC_Newsletter_9_16_21&utm_medium=email&utm_term=0_2cb428c5ad-915c8ac6d6-41080549&mc_cid=915c8ac6d6&mc_eid=d232e07603
Impel NeuroPharma (Seatle, WA; $3.8M SBIR) down 24% [Sep 10, 21] announced the pricing of its underwritten public offering to raise $45M [company press release, Sep 9, 21]
Gevo (Englewood CO; ($1.6M SBIR)up 37% [Sep 9, 21] Chevron and Gevo, announced a letter of intent to jointly invest in building and operating one or more new facilities that would process inedible corn to produce sustainable aviation fuel, which can lower the lifecycle carbon intensity of fuels used in the aviation industry. The new facilities would also produce proteins and corn oil.[joint companies press release, Sep 9, 21]
INmune Bio down 22% [Sep 8, 21]
CorMedix (Berkeley Heights, NJ; $300K SBIR) down 22% Sep 7, 21] provided an update with respect t its resubmission timeline for the DefenCath New Drug [company press release, Sep 7, 21]
Impel NeuroPharma (Seattle, WA; $3.9M SBIR) down 19% [Sep 3, 21] announced that the [FDA] approved TRUDHESA(TM) (dihydroergotamine mesylate) nasal spray (0.725 mg per spray) for the acute treatment of migraine with or without aura in adults. TRUDHESA was previously known as INP104. [company press release, Sep 3, 21]
American Superconductor (Ayer, MA; $24M SBIR) up 21% [ug 31, 21] ComEd, one of the nation's largest electric utilities and AMSC, a leading system provider of megawatt-scale power resiliency solutions that orchestrate the rhythm and harmony of power on the grid(TM), today announced the successful integration of AMSC's REG system, which utilizes high-temperature superconductor wire to enhance the reliability, resiliency and performance of the electric power grid. [joint companies press release, Aug 31, 21]
NeuroMetrix (Woburn, MA; $600K SBIR in the 1980s) down 14% [Aug 31, 21]
startup Psyonic (Champaign, IL; $1.2M SBIR) that's creating a more affordable bionic hand that lets wearers "feel" what they're touching has officially made its product available to the public. ... , developed out of the University of Illinois by founder Aadeel Akhtar, is a high-tech prothesis that provides sensory feedback to its users. The device uses sensors that are embedded in the fingertips of the hand, so when a user touches an object, the skin is stimulated electrically, giving off a tingling or vibration sensation. The device has been in development since 2015 and this week officially became available to users and clinicians across the country. [Jim Dallke, ChicagoInno, Sep 2, 2021]
Watching the last American military plane go wheels up and out of the Afghanistan War reminded me of an old saying: History often repeats itself, but a lot of us would rather not pay attention. [Clarence Page, Chicago Tribune, Sep 1, 21]
Liberty. 47% of undereducated gullible Americans believe they have a constitutional right to act irresponsibly and selfishly -in the name of their perceived freedom- to go and expose others to sickness and death. [commenter, NY Times, Sep 1, 2021]
You don’t need to believe that a never-ending cycle of deficit-funded spending, offset by monetary intervention, is sustainable in order to believe that the scale of spending generally contemplated to deal with an existential threat like climate change, or a societal threat like poverty, is woefully inadequate. You can just believe we need to pay for it. [Robert Rubin reviewing Adam Tooze's SHUTDOWN How Covid Shook the World’s Economy, NY Times Sep 4, 2021]
NeuroMetrix (Woburn, MA; $600K SBIR in the 1980s) down 16% [Aug 30, 21]
NeuroMetrix (Woburn, MA; $600K SBIR in the 1980s) up 66% [Aug 27, 21]
Everspin Technologies (Chandler AZ; $700K SBIR) up 18% Aug 26, 21] reported quarterly financial results
Agenus Pharma (Lexington, MA; 9$1.6M SBIR) is now in the closing stretch of its multidecade effort to bring a drug to market. With the FDA set to decide whether to approve PD-1 drug balstilimab in December, Agenus has published the phase 2 data it hopes will secure authorization in cervical cancer. [Nick Paul Taylor, Fierce Biotech, Aug 27, 21]
BioCryst was ready for the public markets, but after shares sank 14% in the wake of the announcement, ... has withdrawn a proposed $200 million public offering after deciding “current market conditions are not conducive to an offering on terms that would be in the best interests of our current stockholders.” [Fierce Biotech, Nick Paul Taylor, Aug 11, 2021]
Great Duchenne muscular dystrophy (DMD) therapies are just not getting enough medicine into the cells, and PepGen (Alameda, CA; $2.3M SBIR) hopes to change that thanks to a $112.5 million raise that will advance a new candidate into the clinic early next year. [Nick Paul Taylor, Fierce Biotech, Aug 5, 2021]
The same Republican Party that led the establishment of a multitrillion-dollar security state after September 11 doesn’t even want to investigate what happened on January 6. [Ben Rhodes, Foreign Affairs, S/O21]
Suono Bio (Cambridge, MA; one SBIR) raised $12.2M as part of an equity offering worth approximately $15.2M. [BostInno, Aug 2, 221]
Surmodics (Eden Prairie, MN; $23M SBIR) medical device manufacturer, announced that it has acquired privately held Vetex Medical Limited. The Galway, Ireland based medical device developer and manufacturer has focused exclusively on venous clot removal solutions. The transaction expands Surmodics’ thrombectomy portfolio with a second (FDA) 510(k)-cleared device, the ReVene™ Thrombectomy Catheter. [company press release, Jul 6, 21]
II-VI Introduces Heated Ion Implantation Foundry Services for 150 mm Silicon Carbide Wafers [company press release, Jun 15, 21]
Sinking confidence. Less than 40% of small firms say they expect economic conditions to improve; ‘It seems like it is just a bust’ [Ruth Simon, Wall Street Journal, Aug 14, 21]
countless articles report that the U.S. innovation system is lagging behind other nations. However, fewer accounts emphasize the extreme lack of diversity among those who receive funding. ... the innovation budget has systematically disenfranchised hundreds of communities and millions of potential innovators while weakening U.S. innovation outcomes, [Brookings, Aug 12, 21] Hello, "fair share" SBIR was invented forty years ago to fix that problem. Of course, human nature and federal procurement rules defeated that purpose. The "fair-share money went to the best proposers wherever they lived. And they mostly lived where private capital was investing in R&D. Biden's [olitical plan to half of the $40 billion it proposes for upgrades of “research infrastructure” for HBCUs and other MSIs will simply lower the new innovation from its highest potential.
NexImmune (Gaithersburg, MD; #300K SBIR) up 18% [Aug 10, 21] reported quarterly financial resuts
Impel NeuroPharma (Seattle, WA; $3.6M SBIR) down 26% [Aug 10, 21] announced that its pivotal Phase 3, open-label study, STOP 301, was published in the August 7, 2021 edition of Headache: The Journal of Head and Face Pain, the official journal of the American Headache Society [company press release, Aug 9, 21]
bluebird bio down 27% [Aug 9, 21] after the company announced new safety issues, and the suspension of its European commercial operations. [Josh Nathan-Kazis, Barron's, Aug 9, 21]
AVROBIO down 20% [Aug 9, 21]
Dicerna Pharmaceuticals (Lexington, MA; $5.7M SBIR) down 28% [Aug 6, 21] announced positive top-line results from the Company's PHYOX(TM)2 pivotal clinical trial of nedosiran, which is in development as a once-monthly treatment for primary hyperoxaluria (PH), a family of ultra-rare, life-threatening genetic disorders that initially manifest with complications in the kidneys. [company press release, Aug 5, 21]
Novavax dwon 20% [Aug 6, 21] after it delays emergency use submission to FDA of COVID-19 vaccine [MarketWatch, Aug 6, 21]
Everybody gets a say. The democratization of authority spurred by the digital revolution has flattened cognitive hierarchies along with other hierarchies, and political decision-making is now driven by often weaponized babble. [Francis Fukuyama, Foreign Affairs, J/A2020]
Turn about, fair play. The same Republicans who cheered Trump's $2Tr debt increase tax cuts for the rich in 2017 now declare horror as Democrats do the same thing for their concept of government.
Novavax up 19% [Aug 4, 21]
Kopin (Taunton, MA; $9M SBIR) down 19% [Aug 3, 21]
Annovis Bio up 20% [Aug 2, 21] said it is pleased by the positive interim results released on July 28 from Phase II clinical trials of its lead compound, ANVS401 (Posiphen). [company press release, Jul 30, 21]
In essence Biden is defending liberal democracy and the notion that you can’t govern a nation based on the premise that the other half of the country is irredeemably awful. [David Brooks, NY Times, Aug 5, 21]
Six years of Donald J. Trump largely blocking out all other voices in his party have left Republicans without a credible messenger to push vaccines, even if they wanted to. [Reid J. Epstein, NYTimes, Jul 31, 2021]
A simple plan to end America’s vaccine hesitancy: Serve it deep-fried on a stick [Rex Huppke, Chicago Tribune, Aug 5, 21]
INmune (Boca Raton, FL; $700K SBIR) down 23% [Jul 26, 21] announced the design of its upcoming Phase 2 clinical trial of XPro(TM) in patients diagnosed with mild Alzheimer's disease (AD). The announcement is accompanied by the release of additional biomarker data from the Phase 1b AD trial that shows improvement in white matter (myelinated axons) that degenerate in AD patients. [company press release, Jul 26, 21]
Chembio Diagnostics down 29% [Jul 23, 21]
NeuroMetrix (Woburn, MA; $600K SBIR) up 19% [Jul 21, 21]
NeuroMetrix (Woburn, MA; $600K SBIR) up 107% [Jul 21, 21]
Chembio Diagnostics (Hauppauge NY; $7M SBIR) up 159% [Jul 21, 21] announced receipt of a $28.3 million purchase order from Bio-Manguinhos for the purchase of Chembio's DPP SARS-CoV-2 Antigen tests for delivery during 2021 to support the urgent needs of Brazil's Ministry of Health in addressing the COVID-19 pandemic [company press release, Jul 20, 21]
NeuroMetrix (Woburn, MA; $600K SBIR) up 208% [Jul 20, 21] announced that its Quell(R) d evice has received Breakthrough Designation from the U.S. Food and Drug Administration (FDA) for treating the symptoms of fibromyalgia in adults. [company press release, Jul 20, 21]
PLx Pharma up 18% [Jul 20, 21]
Cytokinetics (Sount San Francisco, CA; $500K SBIR) up 40% [Jul 19, 21] announced positive topline results from Cohorts 1 and 2 of REDWOOD-HCM (Randomized Evaluation of Dosing With CK-274 in Obstructive Outflow Disease in HCM), the Phase 2 clinical trial of CK-3773274 (CK-274), an investigational next-generation cardiac myosin inhibitor in development for the potential treatment of hypertrophic cardiomyopathy (HCM). [company press release, Jul 19, 21]
FibroGen down 42% [Jul 16, 21] announced that [FDA] voted to recommend not approving roxadustat, an oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor, for the treatment of anemia due to chronic kidney disease (CKD) in adult patients. [company press release, Jul 15, 21]
Glaukos (San Clemente, CA; $200K SBIR) down 21% [Jul 14, 21]
PLx Pharma up 27% [Jul 13, 21] announced that three stock-keeping units ("SKUs") of VAZALORE, the first and only U.S. Food and Drug Administration ("FDA") approved liquid-filled aspirin capsules, will be available in over 4,500 Walmart stores across the United States in mid-August. [company press release, Jul 13, 21]
Meridian Bioscience (Cincinnati, OH; $600K SBIR) down 23% [Jul 13, 21] provided preliminary revenue results for its third quarter
Gliknik (Baltimre, MD; 41.6M SBIR) an immunology company dedicated to patients with cancer and autoimmune disorders, today announced that it has successfully completed an $11.5 million Series C Preferred Stock financing. [company press release, Jun 24, 21]
Surmodics (EDEN PRAIRIE, MN; $26M SBIR) announced today that it has acquired privately held Vetex Medical Limited. The Galway, Ireland based medical device developer and manufacturer has focused exclusively on venous clot removal solutions. The transaction expands Surmodics’ thrombectomy portfolio with a second U.S. Food and Drug Administration (FDA) 510(k)-cleared device, the ReVene™ Thrombectomy Catheter. [Surmodics press release, Jul 7, 21]
Sirnaomics (Gaithersburg, MD; $1.2M SBIR) announced that it has sealed $105 million in a Series E financing. [company release, Jul 1, 21]
Celldex Thera (Hmpton, NJ; $600K SBIR) up 25% [Jul 12, 21] announced updated data from the Company's ongoing, open label Phase 1b clinical trial of CDX-0159 in patients with antihistamine refractory cold urticaria and symptomatic dermographism, the two most common forms of chronic inducible urticaria. [company press release, Jul 9, 21]
Selux Diagnostics (Cambridge, MA; $2.3M SBIR) an antimicrobial therapy company for Infectious Diseases, has been awarded $14.6M in funding from the Biomedical Advanced Research and Development Authority [BostInno, Jul 1, 21]
II‐VI, a leading provider of wafer-level diffractive optics, announced the introduction of high-efficiency multifunctional metalenses based on a II-VI proprietary platform that enables ultracompact optical sensors for a broad set of applications, [company press release, Jun 23, 21]
Editas Medicine up 23% [Jun 30, 21]
CEL-SCI down 32% [Jun 30, 21]
Kiromic Biopharma down 28% [Jun 30, 21]
Antheia (Palo Alto, CA; $1.6M SBIR) a startup using synthetic biology to produce medicines currently sourced from plants, has raised $73 million in new venture-capital financing. [Brian Gormley, Wall Street Journal, Jun 30, 21]
Kiromac Biopharma (Houston, TX; $1.3M SBIR) down 17%, [Jun 29, 21]
CEL-SCI down 45% [Jun 28, 21]
Kiromac Biopharma (Houston, TX; $1.3M SBIR) down 20%, [Jun 28, 21] announced We intend to use our AI target, Mesothelin isoform 2, in the upcoming first-in-human dosing for solid tumors in 3Q-2021. [company press release, Jun 28, 21]
When labels matter “It’s [infrastructure bailout] full of stuff that isn’t a tax increase and isn’t a spending cut and is just wishful and fanciful.” [Yuval Rosenberg and Michael Rainey, Fiscal Times, Jun 29, 21] If Congress wants to rely on pixie dust to pay for its spending, it has the ultimate power to do so.
When governments act. “But a pandemic is not about mere anxiety [Islam,immigration], it’s about fear for your health and life: You’re not interested in someone confirming your anxiety, you need someone to perform swiftly, and mainstream parties were seen as doing that, while the populist opposition argued against action,” Mr. Krastev said. [Bojan Pancevski, WSJ, Jun 30, 21]
The developer of a line of advanced rotary diesel and multi-fuel internal combustion engines is expanding into the renewable energy game. LiquidPiston's X-Engine, which we've covered previously and is helping the Air Force develop vertical takeoff and landing concepts, can now run on hydrogen gas. [Greg Nichols for Robotics, ZDNet, June 25, 2021]
Cyteir Therapeutics (Cambridge, MA; $2.2M SBIR) up 20% [Jun 25, 21] announced the closing of its [IPO] with gross proceeds $133 million [company press release, Jun 22, 21]
Miromatrix Medical down 16% [Jun 25, 21]
Vision Quest Biomedical (Albuquerque, NM; $1.2M SBIR, founded 2007) awarded a $2M grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases to commercialize ASPIRE, a device that uses AI for cerebral malaria diagnosis. [company press release, Jun 12, 21]
Miromatrix Medical (Eden Prairie, MN; $2.6M SBIR) up 69% [Jun 24, 21] announced the pricing of its upsized [IPO] to raise $43M ... pioneering a novel technology for bioengineering fully transplantable human organs to help save and improve patients' lives. The Company has developed a proprietary perfusion technology platform for bioengineering organs that it believes will efficiently scale to address the shortage of available human organs. [company press release, Jun 24, 21]
Because of development delays, Novavax should expect little uptake for its COVID-19 vaccine in the United States. But there's still a ready market globally, which the shot is well equipped to serve, GlobalData analysts report. [Kevin Dunleavy, Fierce Life Sciences, Jun 24, 21]
Zai Lab (China) will pay MacroGenics (Rockville, MD; $2.6M SBIR) $25 million upfront and make an equity investment of $30 million in common stock. Those are small numbers compared to the up to $1.4 billion that MacroGenics could receive in biobucks for [four CD3- or CD47-based bispecific antibodies for immuno-oncology] as well as additional royalties on annual net sales if the products make it to market. [Kyle LaHucik, Fierce Biotech, Jun 16, 2021[
Synaptogenix (Newark, NJ; $1M SBIR) up 25% [Jun 17, 21]
Anavex Life Sciences up 21% [Jun 16, 21]
PDS Biotechnology down 28% [Jun 15, 21] announced that it has commenced an underwritten public offering of shares of its common stock. [company press release, Jun 14, 21]
Anavex Life Sciences down 17% [Jun 15, 21]
Solid Power (Longmont,CO; $4.6M SBIR) is latest electric-vehicle business to announce plans to go public via a special-purpose acquisition company. ... Decarbonization Plus Acquisition Corporation III DCRC said it would buy Solid Power for $1.2 billion. ... Solid-state batteries promise to replace the [flammable lithium] liquid with a solid. [Steven Wilmot, WSJ, Jun 16, 21]
Anavex Life Sciences up 35% [Jun 14, 21] reported that ANAVEX(R) 2-73 (blarcamesine) and ANAVEX(R) 3-71 (AF710B) are featured in a new peer-reviewed publication in the journal of Expert Opinion on Therapeutic Targets, titled "The emerging role of the sigma-1 receptor in autophagy: Hand-in-hand targets for the treatment of Alzheimer's".
AXT up 20% [Jun 14, 21]
Novan up 18% [Jun 14, 21]
NanoGraf (Chicago, IL; no SBIR) advanced battery material startup, announced a breakthrough in its lithium-ion battery that enables it to be longer-lasting, lighter weight, and have a shortened charge cycle. The company said its battery now has the highest energy density 18650 cylindrical lithium-ion cell in the world, providing a 28% longer run time than traditional cell chemistries. [Jim Dallke, ChicagoInno, Jun 14, 21]
Venture Firm Seeks $50 Million to Back Civilian, National-Security Tech. Newly formed J2 Ventures says it can offer expertise to young health and tech startups on landing Defense Department contracts [Brian Gormley, WSJ, June 14, 21]
After decades of slowing entrepreneurial dynamism, 4.4 million new businesses were started in 2020, by far a modern record. During the first quarter of this year U.S. start-ups raised $69 billion, 41 percent more than the previous record, set in 2018. [David Brooks, New York Times, Jun 17, 21]
Novan (Morrisville, NC; $8M SBIR) up 62% [Jun 11, 21] announced positive topline efficacy and safety results for the B-SIMPLE4 pivotal Phase 3 clinical study of SB206, a topical antiviral gel, for the treatment of molluscum contagiosum ("molluscum"). Molluscum is a common, contagious skin infection caused by the molluscipoxvirus, affecting approximately six million people in the U.S. annually, with the greatest incidence in children aged one to 14 years. [company press release, Jun 11, 21]
Vaxart up 22% [Jun 11, 21]
Heat Biologics down 22% [Jun 11, 21]
Acumen Pharmaceuticals (Livermore, CA; $800K SBIR) is filing for a $100 million [IPO] hot on the heels of the FDA’s conditional approval of Biogen's controversial Alzheimer's disease drug Aduhelm (aducanumab). [Kyle LaHucik, Jun 10, 2021, Fierce Biotech]
ViaCyte (San Diego, CA; $1.7M SBIR) More than two and a half years after raising an $80 million series D, ViaCyte has expanded the round with a $45 million financing tranche. The San Diego-based clinical stage biotech is developing multiple programs aimed at treating type 1 diabetes. [Kyle LaHucik, Fierce Biotech, Jun 9, 2021]
The FDA has lifted a clinical hold placed on bluebird bio’s sickle cell gene therapy in February, making way for the company to get a phase 1/2 trial and phase 3 study of the treatment back on track. [ Amirah Al Idrus, Fierce Biotech, Jun 7, 2021 ]
Some estimate that by 2040, the world's computer chips will demand more electricity than is expected to be produced globally [Max Kozlov reviewing The Ascent of Information: Books, Bits, Genes, Machines, and Life's Unending Algorithm by Caleb Scharf, Science, Jun 4, 2]
Heat Biologics (Morrisville NC; $300K SBIR) up 40% [Jun 10, 21]
Aethlon Medical (San Diego, CA; $2.7M SBIR) down 26% [Jun 10, 21] announced that it has entered into a definitive agreement with a single institutional investor for the purchase in a registered direct offering of 1,380,555 shares of its common stock, [comapny oress release, Jun 10, 21]
Aethlon Medical (San Diego, CA; $2.7M SBIR) up 388% [Jun 9, 21] after major news emerged from the company last week regarding the fight against the novel coronavirus. [Nick Clarkson, Investor Place, Jun 9, 21]
First Solar (Tempe, AZ; $1.6M SBIR) The biggest American-owned solar-panel maker announced plans to invest $680 million in a new Ohio factory, in one of the largest bets on domestic solar manufacturing since China began dominating the industry a decade ago. .... said it plans to begin construction after necessary permits and local incentives have been secured and is aiming to open the plant early in 2023. [Bob Davis, Wall Street Journal, Jun 0, 21]
INmune Bio (La Jolla, CA; $700K SBIR) up 19% [Jun 7, 21]
PDS Biotech (Lawrenceburg, IN; $1.7M SBIR) down 26% [Jun 7, 21]
The Senate approved a bipartisan, $250 billion bill boosting government spending on technology research and development amid rising competition from China and other nations. [Wall Street Journal, Jun 9, 21] big new tech money likely after House passes its version. Then will come the challenge of hiring innovative govenment investors. SBIR history says federal agencies not up to it; only DARPA has succeeded.
Daxor (Oak Ridge, TN; $700K SBIR) up 38% [Jun 4, 21]
American Superconductor up 37% [Jun 4, 21] announced over $19 million of new energy power system orders. [company press release, Jun 2, 21]
Chicago tech hub mHUB is expanding its accelerator program offerings with a new initiative focused on med-tech. mHUB announced it's launching an accelerator program for medical device startups that have "the potential to transform health care." The program expects to launch in the fourth quarter of this year, with applications opening this summer. [Jim Dallke, Chicago Inno, Jun 4, 21]
Ford and BMW are investing $130 million in auto battery maker Solid Power (Louisville, CO; $4.6M SBIR) [Nick Greenhalgh, WiscInno, Jun 4, 21]
ColdQuanta (Boulder, CO; $9M SBIR) has brought on $20 million to help commercialize its quantum computing technology. ... brings ColdQuanta’s total funding to $74 million [Nick Greenhalgh, Colorado Inno, May 13, 2021]
43North (Buffalo, NY) is calling for startups to apply to their seventh competition. The competition, which ultimately selects eight companies, offers founders a chance to secure up to $1 million in funding and land a spot in 43North’s accelerator program. Investments are made in exchange for five percent equity. [43North, Jun 2, 21]
Stellanova Therapeutics (Houston, TX, no SBIR) announced raising $15.5 million in Series A funding ... is developing an antibody that targets fiber blast cells, which protect cancer cells against treatment and promote cancer cell growth. [Chris Mathews, Houston Inno, Jun 6, 21]
Bivacor (Houston, TX; $3M SBIR) raised $22 million through a Series B capital raise and a grant award .. to support the first human studies using its artificial heart device. [Chris Mathews, Houston Inno, May 19, 21]
Grove Biopharma (Chicago, IL; no SBIR), a startup that's creating a novel class of “protein-like polymers” to make drugs that could treat Parkinson's, Alzheimer's, Multiple Sclerosis and other difficult to treat conditions, raised $4 million [Chicago Inno, May 10, 21]
CincyTech, based in the University of Cincinnati’s 1819 Innovation Hub in Avondale, raised $19.7 million for its fifth investment fund. ... to invest in seed-stage startups, as it has done for the past 15 years. [Steve Watkins, CincyInno, May 19, 21]
[Samuel Hammond of the Niskanen Centre] believes that government agencies that fund research have become sclerotic: he sees a “compliance culture” resulting from a risk-averse leadership wary of heavy-handed congressional oversight. That is a problem, says Benjamin Reinhardt, an independent researcher who has studied DARPA, because big wins come from taking risks. “All the value,” he says, “is in the long tail.” ... On paper, the approach is straightforward. Take enormous, reckless gambles on things so beneficial that only a handful need work to make the whole venture a success. [The Economist, Jun 5, 21] SBIR could have done that for the last forty years, but it was invented instead as a fair-share program for uncompetititve R&D companies with only one absolute rule -- spend the money.
Annovis Bio (Berwyn, PA; $900K SBIR) up 27% [Jun 1, 21] announced the notable finding that in a test that measures speed, AD and PD patients both respond with a statistically significant increase in correctly coded fields after 25 days of treatment with ANVS401. The test was part of the Company's ongoing Phase 2a study in AD and PD patients. [comapany press release, Jun 1, 21]
C2N Diagnostics (St Louis, MO; $3.M SBIR) which offers the PrecivityAD™ blood test that can help detect if certain markers for Alzheimer’s disease are in the brain, now has its results available for review. The study appears in Clinica Chimica Acta, the official peer-reviewed journal of the International Federation of Clinical Chemistry and Laboratory Medicine. [company press release, May 27, 21]
San Francisco-based MetaVC Partners is raising $100 million for its first fund, and has already received capital from Bill Gates, co-founder of Microsoft Corp. and an anchor investor in the fund, and Nathan Myhrvold, formerly chief technology officer at Microsoft who runs intellectual-property firm Intellectual Ventures. .... to invest in startups commercializing metamaterials, a budding area of materials science that could improve the performance and reduce the size and weight of devices such as lenses and sensors ... Messrs. Alliegro and Burke estimate that about $1 billion has been invested in metamaterials startups to date. [Yuliya Chernova, Wall Street Journal, Jun 3, 21] An innovation enterprise unlikely to get bogged down in predictable incremental improvements for the mission of a government agency.
miRecule (Rockville, MD; $1.7M SBIR) raised $5.7M in fresh funding investments to take its RNA therapies for drug-resistant cancers to the clinic, CEO Anthony Saleh [said] positioning the company to start human testing for its lead candidate to treat head and neck cancer. [DCInno. May 27, 21]
Dynetics (lots of SBIR), a wholly owned subsidiary of Leidos , has secured a potential $90 million contract to build a laser-based technology to measure the temperature, pressure, carbon dioxide and oxygen within the Orion spacecraft during NASA's planned human missions to the moon. [govconwire.com, Jun 1, 21]
Annovis Bio (Berwyn, PA; $900K SBIR) up 127% [May 21, 21] announced new results from a double-blind, placebo-controlled study of ANVS401, its lead drug candidate for the treatment of AD and PD. Patients treated with ANVS401 for 25 days showed statistically significant cognitive improvement as measured by the Alzheimer's Disease Assessment Scale-Cognitive Subscale 11 (ADAS-Cog11). The 11-part test is one of the most frequently used tests to measure impaired cognition in clinical trials for AD. [company press release, May 21, 21]
Ultralife up 23% [May 18, 21]
Bivacor (Houston, TX; $2M SBIR) recently closed a series B funding round for a total of $19 million, ... also received another $3 million from the National Institutes of Health, in the form of a small business grant from the National Heart, Lung and Blood Institute. [Andrea Park, Fierce Biotech, May 20, 21]
In conflict zones around the world today, impunity is on the march. [Ed Milliband, Foreign Affairs, J/J 21] Impunity brings on war and disease to naturally reduce world population.
“Right now in Washington, D.C, it would be hard to get members of Congress to agree on the proper way to butter toast", Sen. Ron Wyden (D-OR), the committee chair, said.
New political math. US Representtive from Texas says not a single Covid death in Texas from March 2 ending of mask mandate. Texas health department says 3600 such deaths. Does 3600=0?
CEL-SCI (Vienna, VA; $2.6M SBIR, founded 2007) down 15% [May 17, 21]
ColdQuanta (Boulder, CO; no SBIR) announced it raised $20 million to continue commercializing cold atom quantum technology and accelerate hiring initiatives. ...has developed technology that allows engineers to cool atoms to a few millionths of a degree above zero and use lasers to manipulate the make-up of the atom. By altering their atomic composition, ColdQuanta is able to manufacture components for computing, radio frequency sensing, timekeeping and communications. [Cassidy Ritter, bulletincolorado.com, May 12, 21]
Interline Therapeutics (San Francisco, CA; no SBIR), which launches out of Foresite Capital’s incubator with $92 million to develop drugs that alter protein communities to treat disease. [Amirah Al Idrus, Fierce Biotech, May 13, 21]
Whatever the progress, Business leaders are confident that they can stop almost all of President Biden’s proposed tax hikes by pressuring moderate congressional Democrats, Politico’s Ben White reports. [Yuval Rosenberg and Michael Rainey, Fiscal Times, May 18, 21], someone else should pay for it.
“I cannot believe that we used to celebrate birthdays by eating a cake that someone has blown all over,” said Brian Labus, an epidemiologist at the University of Nevada, Las Vegas.
Second Sight Medical Products up 28% [May 12, 21] announced two-year results of its Early Feasibility Study (Study) of the Orion Visual Cortical Prosthesis (Orion). The Study is a single arm six subject study at UCLA and Baylor College of Medicine. The Study was paused due to the COVID-19 pandemic, but is now resumed at both centers. [company press release, May 12, 21]
Bren-Tronics (Commack, NY; $1M SBIR), Inventus Power (no SBIR), Navitas Systems (Woodridge, IL; $1.6M SBIR) government solutions group and Ultralife (Newark, NY; $200K SBIR) have secured spots on a potential nine-year, $1.25 billion contract for a lightweight wearable battery being developed under the Army's Tactical Power Generation Program [Christine Thropp, govconwire.ccom. May 13, 21]
Plug Power up 18% [May 11, 21]
Fluidigm up 18% [May 11, 21]
Dynaxax Tech down 19% [May 10, 21]
The pandemic has shown how hard it can be to change the minds of ideologically driven politicians and hardened vaccine sceptics or to beat back disinformation on Twitter. [Helen Pearson, Nature, May 12, 21]
ChemoCentryx down 62% [May 7, 21]
The most recent annual report from the (SBA) concludes that a majority of participating federal agencies did not comply with the mandated minimum spending requirements for the (SBIR/STTR) programs. [SSTI, May 6, 21] The only thing Congress really cares about, and is easy to understand, for SBIR is getting the money to their constituents. Whether SBIR is worth the bother is too hard to judge witout some deep economics.
BioCryst Pharma up 21% [May 6, 21] reported quarterly earnings
COnovate (Milwaukee, WI; $1.4M SBIR) startup developing a novel anode material for lithium-ion batteries, announced the successful completion of its initial round of financing. The COPHITE material is a patented 2D material that is the first solid form of carbon monoxide that exists at room temperature and pressure. It was discovered by Dr. Hirschmugl and her co-founder Dr. Marija Gajdardziska-Josifovska at the University of Wisconsin-Milwaukee. [company press release, May 4, 21]
OnLume (Madison,WI; $3.4M SBIR, founded 2015) announced the completion of its [$7M] Series A funding to assist its plans for commercial launch. [company press release, Apr 30, 21]
RNAimmune, a biopharmaceutical company specializing in discovery and development of mRNA-based therapeutics and vaccines, announced execution of definitive agreements for a seed round financing of $10 million. RNAimmune is a spin- off entity from Sirnaomics (Gaithersburg; $1.2M SBIR), a biopharmaceutical company engaged in the discovery and development of RNAi therapeutics against cancer and fibrotic diseases. [company press release, Apr 21, 21]
CryoLife up 24% [Apr 30, 21] reported quarterly financials
Vaxart up 17% [Apr 30, 21]
Novel Microdevices (Baltimore, MD; $1.3M SBIR) a developer of an innovative molecular diagnostics platform, announced today that CARB-X has awarded it up to $13.8 million in non-dilutive funding to develop its next-generation rapid molecular test for the diagnosis of sexually transmitted bacterial infections, including Chlamydia trachomatis and Neisseria gonorrhoeae. [company press release, Apr 6, 21]
Galera Therapeutics (Malvern, PA; $900K SBIR) up 20% [Apr 29, 21] announced "The data from this trial continue to impress, showing consistent and durable benefits across multiple measures, including the most important for the patient, overall survival," said [CEO] Mel Sorensen, [company press release, Apr 28, 21]
Arcadia Biosciences (Davis, CA; $5M SBIR) announced it has acquired the assets of Agrasys SA, a food ingredients company based in Barcelona, Spain. The transaction includes the physical and intellectual property assets to enable Arcadia to commercialize Tritordeum, a proprietary cereal grain that was developed at the Instituto de Agricultura Sostenible — Consejo Superior de Investigaciones Científicas, (IAS-CSIC) the largest public institution dedicated to agricultural research in Spain [company press release, Apr 19, 21]
[Biden’s plans] represent the most dramatic shift in federal economic and social welfare policy since Ronald Reagan was elected 40 years ago. Reagan’s small-government philosophy resulted in a decades-long squeeze on the federal government, especially domestic spending, and on tax policies that mainly benefited the wealthiest Americans. [Dan Balz, WashPo, Apr 28, 21] The otherwise eloquent Republican response conveniently omitted the facts that Reagan’s trickle-down supply side economics has disproportionately further enriched the already rich. But Biden’s grand plan will be met by a hailstorm of objection by anyone who is called upon to pay for the many benefits. After all, it's American democracy to want more than you're willing to pay for.
“Humanity is running an ecological Ponzi scheme in which society robs nature and future generations to pay for short-term economic enhancement today.” “Most economies operate on the basis that counteraction now is too costly to be politically palatable. Combined with disinformation campaigns to protect short-term profits it is doubtful that the scale of changes we need will be made in time” Professor Ehrlich says. [Flinders University (Australia), Apr 25, 21] The readiness to borrow trillions for the pandemic bailout will eventually repeat with any climate "solution."
Inovio Pharma down 25% [Apr 23, 21] said early Friday that the U.S. government had decided to pull funding for a Phase 3 trial of the company’s experimental Covid-19 vaccine, given the “broad availability” of Covid-19 vaccines in the U.S. Inovio (ticker: INO) said it now plans to run a Phase 3 trial largely outside of the U.S. That would likely impact its ability to get the vaccine approved by the Food and Drug Administration. [Josh Nathan-Kazis, Barron's, Apr 23, 21]
CEL-SCI up 22% [Apr 22, 21]
INmune Bio (up 18% [Apr 21, 21]
Dynavax Technologies (Berkeley, CA; $6.5M SBIR) down 18% [Apr, 20, 21]
INmune Bio (La Jolla, CA; $700K SBIR) down 17% [Apr 19, 21]
Volexion (Wilmette, IL; $200K SBIR) landed $1.1M to improve the performance of lithium-ion batteries just landed funding from a pair of climate-focused VC firms. [Jim Dallke, ChicagoInno, Apr 8, 21]
this country sent us to the front lines with none of the equipment needed for the battle [Sharon Griswold, an emergency room doctor in Pennsylvania, quoted by WashPo, Apr 22, 2012] The medics see a country objecting to a simple, cheap anti-virus defense - a nose and mouth mask that would have made life safer and more tolerable for medics. ‘You don’t have to set yourself on fire to keep other people warm.’ [Mona Masood, a psychiatrist who has counseled dozens of doctors in mental crisis in recent months]
Trump’s $27m-a-mile border wall being scaled with $5 ladders [The Guardian, Apr 24, 21] Trump's generals may well have told him that an unguarded wall is little barrier to crossing. But the wall was only ever an expensive poltical symbol. Arizona governor Janet Napolitano pronounced long ago "Show me a 50-foot wall, and I'll show you a 51-foot ladder."
Recursion Pharmaceuticals (Salt Lake City, UT; $3.5M SBIR) up 74% [Apr 16, 21] announced its [IPO] pricing to raise $436M [company press release, Apr 16, 21]
Akoya Biosciences (San Francisco, CA; $150K SBIR) up 30% [Apr 16, 21]
INmune Bio (La Jolla, CA; $700K SBIR) up 26% [Apr 16, 21]
Cleveland BioLabs up 20% [Apr 13, 21]
What researchers hope for is the unexpected. What funders prefer is to know the outcome in advance. [Andrew Crumey reviewing Genesis by Guido Tonelli, WSJ, Apr 17, 21] Safe SBIR by government agencies and experienced conpanies won't make for much innovation, even though both company and agency declare SBIR success.
FLIR Systems announced it has won a [DARPA] contract to rapidly develop novel fabrics with embedded catalysts and chemistries that can fight and reduce chemical and biological threats upon contact. The revolutionary fabrics will be incorporated into protective suits and other equipment such as boots, gloves, and eye protection that can be worn by troops on the battlefield, medical experts, healthcare workers, and more. FLIR received $11.2 million in initial funding for the potential five-year effort worth up to $20.5 million, including options. [company press release, Apr 12, 21]
Magic economics. The U.S. budget deficit grew to a record $1.7 trillion in the first half of the fiscal year [John McCormick, WSJ, Apr 13, 21] And nobody has (wants) to pay more taxes for the extra spending. Meanwhile, the lightly taxed profits from that spending flow upward to the wealthiest few percent of the population. And the share of the national wealth held by the richest keeps growing. At the bottom part of the economy, jobs are disappearing and pay barely keeps up with cost of living for decades. Yet the people keep electing friends of the wealthy to Congress and state legislatures. Is that not magic? And now more magic: Republicans have taken to calling themselves the party of the working class... shattering traditional conservative economic positions. [Gerald Seib, WSJ, Apr 13, 21]
Volexion (Chicago, IL; $200K STTR, founded 2018) materials startup developing a graphene coating for lithium-ion batteries to improve the performance ... just landed $1.1 million part of a $2.2 million round from a pair of climate-focused VC firms. ... founded by Northwestern professor Mark Hersam, [Jim Dallke, ChicagoInno, Apr 9, 21]
ValenzaBio (Bethesda, MD; no SBIR) reeled in a $70 million series A round that will propel a pair of monoclonal antibody programs toward the clinic. Those include a treatment for an autoimmune kidney disease, which is poised to start a phase 1b/2a study in the second quarter of this year, and a treatment for thyroid eye disease (TED) licensed from Pierre Fabre Medicament. [Amirah Al Idrus, Fierce Biotech, Apr 8, 21]
Traditional skepticism about government’s economic role is rooted in the belief that private markets, driven by the profit motive, are efficient, while governments are wasteful. But the excesses of private markets in recent decades – the rise of monopolies, the follies of private finance, extreme concentration of income, and rising economic insecurity – have taken the shine off the private sector. [Dani Rodrik, Project Syndicate, Apr 3, 21] Warning: good ideas must withstand political grandstanding.
Fibrogen (South San Francisco, CA; $1.3M SBIR) down 43% [Apr 7, 21]
China is increasing its strategic R&D as a share of its economy, as a share of whatever metric you want to use in a way that we have let deteriorate. And so the thing that has changed is that we’ve lived through a decade where China has been meticulously thinking about making those investments, marshaling those investments — not all successful, but all with a deliberate focus on trying to build its own industrial base and its own intellectual and innovation base. And we have, for the better part of a decade, ignored or derogated and undermined those levers. [Brian Deese, Presidential economic advisor, Apr 8, 21]
Our self-government experiment struggles as 75% approve of the President's pandemic management while resisting any enforceable ccommands to act responsibly. The acts of a teenager groping for independence. Meanwhile our politicians hustle to get in front of the crowd they profess to lead. The bad news: there is probably no better altenative as famously expeessed by Winston Churchill
Second Sight Medical Products up 27% [Apr 6, 21]
Molecular Templates (Austin, TX; one SBIR) down 23% [Apr 5, 21] announced that, following discussion with its co-development partner Takeda, MTEM will assume full rights to TAK-169 including taking control of clinical development from Takeda. In addition, MTEM announced the decision to discontinue development of MT-3724, MTEM's only first-generation ETB. [company press release, Apr 5, 21]
ACADIA Pharmaceuticals down 17% [Apr 5, 21]
By 2050 output of cobalt, graphite and lithium, for instance, would have to be more than 450% higher than in 2018 to meet battery demand. [The Economist. Apr 3, 21]
Double standard. Apparently McConnell and these guys are decrying the influence of corporations but not their money? I don’t understand where the line is. They can pack your pockets with cash, but they can’t talk to you or try to persuade you? [Dick Harpootlian, state senator in SC, Apr 6, 21]
Rgenta Therapeutics (Cambridge,MA; $400K Phase 1 SBIR), focusing on developing RNA-targeting medicines for historically undruggable disease-relevant targets, raised $4M in equity in a $38M funding round, per an SEC filing. [Rowan Walrath, BostInno, Apr 2, 21]
NBD Nanotechnologies (Lexington, MA; $1.6M SBIR) which develops advanced liquid repellant surface coatings and additives, raised $1.4M in debt in a $1.5M funding round, per an SEC filing. [Rowan Walrath, BostInno, Apr 2, 21]
An accelerator program from U.S. Air Force Lab and MassChallenge, a two-year pilot, has its second cohort. The second group includes Atomic-6, BoatBox Technologies, CorePower Magnetics, Inergy, Kinnami Software, Measure Global, OxbyEl Technologies, Particle.One, Rhoman Aerospace and Sentenai. The group gets special mentorships and support from experts at MassChallenge and the Air Force. [BostInno, Apr, 1, 21] One company had one SBIR. Maybe SBIR's rigid structure, and SBIR mills with hundreds of awards over three decades, should be shrunk, and more flexible opportunities opened. SBIR was always a fair-share handout program that Congress focused only on the mandated money being spent with the small biz world.
Intevac (Santa Clara, CA; $5M SBIR) up 32% [Mar 31, 21]
Kopin up 17% [Mar 31, 21]
Emalex Biosciences (Chicago, IL; no SBIR) The biotech startup that's developing treatments for central nervous system movement disorders raised $35 million. The startup says there are currently three Phase 2 clinical trials underway for its medicine, which will evaluate the efficacy and safety of its drug. [Katherine Davis, Chicago Inno, Mar 31, 21]
fix 20,000 miles of roads and 10,000 bridges, while also addressing climate change and racial inequities and raising corporate taxes. ... plus $180 billion for research and development [Jim Tankersley, NY Times, Mar 31, 21] What's not to like? Paying for it by any living person. Don't tax you, don't tax me/ Tax that guy behinnd the tree. [late Sen Robert Byrd]
Annovis Bio (Radnor, PA; $900K SBIR) down 16% [Mar 29, 21]
Ecovative Design (Green Island, NY: $4.5M SBIR) raised $60M in Series D financing (Albany Business Review, Mar 30, 21]
The JobsOhio Capital Growth Initiative picks up where last year's JobsOhio innovation Fund [with $50M] to help young companies survive the pandemic and be ready to grow again left off. [Mary Vanac, Cleveland Business Journal, Mar 29, 21]
Bills are for bragging. the US House of Representatives Committee on Science, Space, and Technology introduced a bipartisan bill that outlines plans to more than double the National Science Foundation’s budget and create a new technology directorate. [Asher Jones, The Scientist, Mar 29, 2021] In a world of pandemic and unlimited government spending, it might even happen.
XOMA up 20% [Mar 26, 21]
Rubius Therapeutics down 20% [Mar 26, 21]
Vaxess Technologies (Cambridge, MA; $4.3M SBIR) which is behind a smart patch designed to slowly release vaccines and other treatments into the skin, raised $2M in debt, according to an SEC filing. [BostInno, Mar 29, 21]
Coherent announced that its board of directors has determined to accept the II-VI merger proposal for a value of $7B. [Coherent press release Mar 25, 21]
More fuel for the flame. Biden also reiterated his call for government investment in science and research as a way to compete with China. "Back in the ‘60s we used to invest a little over 2% of our entire GDP in pure research and investment in science. Today it’s 0.7%. I’m going to change that." [The Fiscal Times, Mar 25, 21]
It is difficult to know whether Mr Trump, a huckster raised on the all-American dictum that the best salesmen believe their own spiels, actually thinks the election was stolen from him. The con-man’s eternal excuse is that he says what the rubes want to hear. [The Economist reviewing Cass Sunstein's Liars, Mar 20, 21]
Second Sight Medical Products down 20% [Mar 24, 21]
Debt before taxes. Indeed, the whole idea of paying for government spending with new revenues is apparently so foreign to Republicans and their Senate leader Mitch McConnell that they think it’s some sort of devious trick: "The Trojan horse will be called infrastructure. Inside the Trojan horse will be all the tax increases," McConnell said. [Jonathan Bernstein, Bloomberg, Mar 24, 21] Tax cuts and understaffed IRS for the wealthy and unlimited military spending make the Republican core dogma that has kept them in effective control of lawmaking for four decades.
Ionis Pharma down 22% [Mar 23, 21] after the biotech firm announced the halt of a Phase 3 trial of an experimental Huntington’s disease treatment called tominersen. [Barron's Mar 23, 21]
Hydrogeologic (Herndon, VA; three Phase 1 SBIRs long ago] won a spot on a $240 million [Army] contract to help the military branch mitigate potentially hazardous munitions found at defense training and testing areas. [Matthew Nelson, govconwire, Mar 22, 21]
Inflammatix (Burlingame,CA; $1M SBIR) a pioneering molecular diagnostics company, announced the closing of a $102 million Series D round of financing to support development and commercialization of its novel immune response diagnostics portfolio. [company press release, Mar 16,21]
Solid Biosciences down 32% [Mar 16, 21] reported encouraging interim functional (NSAA, 6MWT and PFTs) and biomarker data, and patient reported outcome measures (PROMs) from six patients after treatment in the ongoing IGNITE DMD Phase I/II clinical trial of its lead gene therapy candidate, SGT-001. [company press release, Mar 15, 21]
Zynerba Pharma down 27% [Mar 16, 21]
Rubius Therapeutics (Cambridge, MA; no SBIR) up 84% [Mar 15, 21], a clinical-stage biopharmaceutical company that is genetically engineering red blood cells to create an entirely new class of cellular medicines called Red Cell Therapeutics(TM), announced initial clinical, pharmacodynamic and tumor trafficking data from its ongoing Phase 1/2 clinical trial of RTX-240 in patients with advanced solid tumors. [COMPANY PRESS RELEASE, Mar 15, 21]
Zynerba Pharma up 49% [Mar 15, 21]
the Air Force wants a shortcut to an unmanned electric vertical takeoff and landing (eVTOL) concept for urban transport. The secret sauce? Pairing emerging electric vehicle technology with an innovative rotary internal combustion engine to keep batteries charged and extend flight times. ... AF awarded an STTR contract to LiquidPiston (Bloomdfield, CT; $400K prior SBIR), a developer of an advanced rotary internal combustion engine called the X-Engine. Paired with a generator, the X-Engine can be configured to charge the eVTOL vehicle's battery and keep it charged during flight, significantly extending the range of an electric propulsion system. Alternatively, it can be configured in parallel with an electric drive, using the engine directly to produce thrust or lift. [Greg Nichols for Robotics, zdnet.com, Mar 15, 21]
Pluton Biosciences (St Louis, MO; no SBIR) signed a research agreement with global life sciences company Bayer AG to investigate the development of an all-natural, microbial-based carbon-capture soil amendment for growers. Collaborating with Bayer, Pluton will use its Micromining Innovation Engine to identify and develop microbes currently found in soil that can store carbon and nitrogen. [company press release, Mar 2, 21]
COnovate (Shorewood, WI; $1.3M SBIR) is receiving a $100,000 phase 2 state matching grant. developing materials designed to add battery capacity and charging speed to lithium ion batteries. [Nick Williams, WisconsinInno, Mar 11, 21]
Scienss Biotechnology (one SBIR) which makes recombinant proteins for use as therapeutics in the livestock industry is receiving a $100,000 phase 2 state matching grant [Nick Williams, WisconsinInnoInno, Mar 11, 21]
GoDx (Madison, WI; one SBIR) developing and commercializing low-cost, rapid diagnostics for infectious diseases. The company has developed a paper strip test that can detect the bugs that cause diarrheal diseases from stool, which will help treat the second leading cause of death in children under age 5 is receiving a $100,000 phase 2 state matching grant [Nick Williams, WisconsinInnoInno, Mar 11, 21]
Second Sight Medical Products up 36% [Mar 12, 21]
Novavax has linked its COVID-19 vaccine to 100% efficacy against severe disease in countries where variants of concern are prevalent. The final phase 3 data suggest NVX-CoV2373 may protect against the worst outcomes caused by the coronavirus variants, even though the mutations limit its efficacy. [Nick Paul Taylor, Fierce Biotech, Mar 12, 21]
Prometheus (Sharon, MA; $8M SBIR) has upsized its IPO, positioning it to reel in $190 million to bankroll clinical development of an anti-TL1A monoclonal antibody in IBD. [ Nick Paul Taylor, Fierce Biotech, Mar 12, 21 ]
PhaseBio Pharma (Malvern PA; $3.6M SBIR) is signing a manufacturing partner for its Brilinta reversal agent as it ushers the drug through phase 3 and, it hopes, FDA approval. [Amirah Al Idrus, Fierce Biotech, Mar 11, 21]
Grifols is dropping $80 million to acquire the outstanding shares of its partner, polyclonal antibody developer GigaGen (South San Francisco, CA; $10M SBIR) . [Amirah Al Idrus, Fierce Biotech, Mar 10, 21]
Vuzix up 21% [Mar 11, 21]
In this edition of SSTI Useful Stats, we attempt to go beyond these measures to estimate states’ untapped potential for capturing future SBIR awards. [SSTI, Mar 10, 21] Pure fair-share politics which explains part of SBIR's mediocre results after three decades.
Second Sight Medical Products down 25% [Mar 10, 21]
The traditional skepticism toward industrial policy is well deserved. Once Washington starts writing checks for semiconductors, other industries may get in line with the outcome determined more by political clout than economic merit. [Greg Ip, WSJ, Mar 10, 21] Meanwhile, Asia makes more and more chips - an unavoidably strategic commodity.
Northvolt (Sweden) announced the acquisition of Cuberg (Emeryville, CA; $1.4M SBIR) battery technology company delivering high-performance lithium metal cells produced on existing lithium-ion manufacturing lines for electromobility solutions. Cuberg spun out of Stanford University in 2015 with the goal of commercializing next-generation battery technology based on a groundbreaking liquid electrolyte combined with a lithium metal anode. [Northvolt press release, Mar 9, 21] terms not disclosed
Second Sight Medical Products (Sylmar, CA; $200K SBIR) up 32% [Mar 9, 21]
Fuel Cell Energy up 21% [Mar 9, 21]
Graybug Vision (Redwood City, CA; $700K SBIR) down 51% [Mar 9, 21] provided preliminary topline data from the 12-month treatment phase of its Phase 2b ALTISSIMO trial of GB-102 for the treatment of wet age-related macular degeneration (wet AMD), Graybug's proprietary microparticle depot formulation of sunitinib malate injected intravitreally. [company press release, Mar 8, 21]
ACADIA Pharmaceuticals down 45% [Mar 9, 21] with the news that the [FDA] had “identified deficiencies” in the company’s application to expand the label of its drug pimavanserin. [Josh Nathan-Kazis, Barron's, Mar 9, 21]
Second Sight Medical Products (Sylmar, CA; $200K SBIR) up 103% [Mar 8, 21] announced U.S. Food and Drug Administration (FDA) has approved the Argus 2s Retinal Prosthesis System, a redesigned set of external hardware (glasses and video processing unit) initially for use in combination with previously implanted Argus II systems for the treatment of retinitis pigmentosa (RP). [company press release, Mar 5, 21]
Vuzix down 14% [Mar 8, 21]
The USG announced on February 19th a plan for an Advanced Research and Invention Agency (ARIA), which is modelled on America’s Advanced Research Projects Agency. That is a promising start. ARIA’s purpose is to fund high-risk, high-reward research, probably by directly funding exceptional scientists. But money is not all that matters. The successful translation of life-science research into treatments during the pandemic (see article) suggests some inexpensive measures that can also make a difference. [The Economist, Feb 27, 21] It's easier to announce a new DARPA-like creature but hard to make one work like the original now several decades old.
Five Prime Therapeutics (no SBIR) up 79% [Mar 4, 21] Amgen and Five Prime Therapeutics, a clinical-stage biotechnology company focused on developing immuno-oncology and targeted cancer therapies, today announced an agreement under which Amgen will acquire Five Prime Therapeutics for an equity value of approximately $1.9 billion. This acquisition adds Five Prime's innovative pipeline to Amgen's leading oncology portfolio. [joint companies press release, Mar 4, 21]
Vuzix down 23% [Mar 4, 21]
Pushing the wet noodles. DARPA will start formalizing and expanding a pilot program that connects its research teams to business expertise to help take technologies out of the lab and into production. In a partnership with nonprofit venture capital firm In-Q-Tel, the Embedded Entrepreneurship Initiative will provide 150 DARPA research teams with funds to hire business executives to develop go-to-market strategies, commercialization mentors and engagement with a DARPA working group stacked with corporate investors over the next five years. [Mila Jasper, govconwire.com, Mar 5, 21] Although DARPA is the most imaginative DOD R&D program, it is still a government program limited by appropriation law to doing government R&D. Its last big push into commercialization died a horrible death with firing of the DARPA Director by the GHWBush administration. A proper use of its R&D is to select companies and technologies that have the best potential for attracting private capital after proof of the concept. One useful step is to require third party validation investment during R&D to pursue the post-development. Anyway it's unlikely that a government hired business advisor will have the inspiring vested interest in the technology and its owner. For further perspective, troll thru the Clinton adminstration files of the DARPA spin-off efforts. Been there, done that.
NanoViricides (Shelton, CT; no SBIR) up 58% [Mar 2, 21] reported on the strong pan-coronavirus effectiveness of its two COVID-19 clinical drug candidates for which the Company is preparing a pre-IND application. [company press release, Mar 2, 21]
Solid Biosciences up 26% [Mar 2, 21]
FibroGen (South San Francisco, CA; $1.3M SBIR) down 25% [Mar 2, 21] FibroGen and partner, AstraZeneca announced that the Cardiovascular and Renal Drugs Advisory Committee of [FDA] will hold an advisory committee (AdCom) meeting to review the new drug application for roxadustat in the U.S. [company press release, Mar 1, 21]
Pear Therapeutics (Boston, MA; $1.6M SBIR) prescription digital therapeutics company, raised an additional $20M in equity, per an SEC filing [BostInno, Mar 3, 21]
Fearing not the virus. Texas businesses will be able to operate at full capacity and state residents will no longer be required to wear masks to visit them beginning March 10, Gov. Abbott said. [Wall Street Journal, Mar 3, 21]
modern American politics can be reduced to a single question: How long can Paducah tell Seattle what to do? [Ronald Brownstein, Atlantic, Oct 30, 20]
Vuzix up 25% [Mar 1, 21] announced that the Company's M400 and M4000 Smart Glasses now support Microsoft Teams. [company press release, Mar 1, 21]
Iteris (Santa Ana, CA; $700K SBIR in 2012) up 23% [Mar 1, 21] the global leader in smart mobility infrastructure management, today announced that its Board of Directors has reviewed and unanimously rejected the non-binding, unsolicited proposal disclosed today by Rekor Systems to acquire Iteris for consideration consisting of approximately 17% cash and 83% Rekor shares at current stock prices. [company press release, Mar 1, 21]
Athenex down 55% [Mar 1, 21]
ChromaDex (Irvine, CA; $800K SBIR) down 26% [Feb 26, 21]
Applied Optoelectronics down 17% [Feb 26, 21]
Vigilance still needed. Taking the first hint of a downward trend as a reason to reopen is how you get to even higher numbers. aid Marc Lipsitch, an epidemiologist at the Harvard T.H. Chan School of Public Health. .... But Looking ahead to late March or April, the majority of scientists interviewed by The Times predicted a fourth wave of infections. [Apoorva Mandavilli, NY Times, Feb 27, 21]
Ideas that might once have been confined to a pamphlet are now easily available on the internet, a space where anyone can be an expert and where conspiracy theories can provide a splendid living for those who peddle them. [Andrew Stuttaford reviewing Michael Butter’s The Nature of Conspiracy Theories, WSJ Mar 1, 21] Alas, America has a large audience of gullible netizens.
ChromaDex (Irvine, CA; $800K SBIR) up 92% [Feb 25, 21] announced results from the study "Combined Metabolic Activators Accelerates Recovery in Mild-to-Moderate COVID-19" were published Feb. 20 on medRxiv, a preprint publication website. The Phase 3 study demonstrated that patients with mild-to-moderate COVID-19 receiving standard of care experienced a 3.5 day reduction in recovery time when receiving an added nutritional protocol. Aimed at improving mitochondrial function, the protocol included nicotinamide riboside (NR), L-serine, N-acetyl-L-cysteine (NAC), and L-carnitine tartrate. [company press release, Feb 24, 21]
Elixirgen Therapeutics (Baltimore, MD; one SBIR) is gearing up to launch a pair of clinical trials this year — one for its new drug that targets bone marrow failure syndromes, and another for its version of a Covid-19 vaccine. [newsbreak.com, Feb 25, 21]
Theradaptive (Frederick, MD; $1.1M SBIR) biotechnology company specializing in regenerative therapeutics, announced the closure of a $6.2 million Series A investment round ... brings the total investment to $17.4M to date [company press release, Jan 9, 2021]
Novavax has fully enrolled its late-stage clinical trial of its experimental Covid-19 vaccine with 30K participants at 118 sites across the U.S. and Mexico. The study population focuses on people across diverse populations in age, race and ethnicity, and co-morbidities most vulnerable to the virus. And it advances the candidate aiming to report data at the end of Q1 or in early Q2 — which, if positive, would pave the way for it to reach patients. The Gaithersburg vaccine maker also has a new MOU with Gavi, the Vaccine Alliance, to ultimately provide 1.1B doses of its vaccine to at-risk groups as part of an international initiative. [Sara Gilgore, DCInno, Feb 25, 21]
NexImmune (Gaithersburg, MD: $3300K SBIR) closed its IPO with $126.5M in gross proceeds for two product candidates, now in early-stage clinical trials for acute myeloid leukemia and multiple myeloma, and its preclinical pipeline, which includes candidates for solid tumor and autoimmune diseases. The funding would also fund manufacturing activities, further use of its tech platform, as well as working capital and general corporate purposes, the company said. [Sara Gilgore, DCInno, Feb 25, 21]
Immunome up 52% [Feb 24, 21]
Cancer Genetics up 22% [Feb 24, 21]
Aqua Metals (no SIR) up 18% [Feb 24, 21] announced it has filed a provisional patent for recovering high-value metals from recycled lithium-ion batteries. [company press release, Feb 24, 21]
Solid Biosciences up 42% [Feb 23, 21]
AeroVironment has acquired the intelligent systems group [ISG] of Progeny Systems (Manassas, VA; $130M SBIR) through a $30 million cash transaction as part of efforts to drive autonomy and artificial intelligence technology development work and expand robotic systems engineering support for defense and commercial clients. AeroVironment said it will merge ISG with its MacCready Works Advanced Solutions team and make an additional payment of up to $6 million to Progeny Systems over three years if the acquired group meets specific performance targets. ISG is headquartered in Manassas, Virginia, and has 40 employee [Jane Edwards, govconwire.com, Feb 25, 21]
Controlling the enemy's counter-attack. Moderna said it has made the initial batch of doses of a new Covid-19 vaccine designed to better protect people against a new strain of the coronavirus that has shown some resistance to the company’s original vaccine. .... said it shipped the new shots to the National Institutes of Health to conduct the first human study of the variant vaccine, which could start within weeks. The new vaccine, code-named mRNA-1273.351, is designed to better match the virus variant that was first identified in South Africa but has since spread elsewhere. [Peter Loftus, Wall Street Journal, Feb 24, 21]
You can't beat something with nothing. instead of looking to the U.S. for help, Latin America is so far relying on Washington’s global rivals: China and Russia. In Argentina and Bolivia, authorities have begun vaccinating with Russia’s Sputnik V, which will soon arrive in Mexico. Chile began inoculating this month with 4 million doses of China’s Sinovac vaccine. [Ryan Dube and Luciana Magalhaes, Wall Street Journal, Feb 25, 21] America Firsters will say so what.
Choose better parents. Thanks to advances in technology, the cost of sequencing an individual’s DNA has declined a million-fold since 2003—the equivalent, he says, of a Ferrari plummeting from $350,000 to less than 40 cents. At the level of DNA, humans are 99.9% identical. On the other hand from science, Your ZIP Code, it’s said, is often a better predictor of health than your genetic code. [David Shaywitz reviewing The Genome Odyssey By Euan Angus Ashley WSJ, Feb 25, 21]
ChromaDex (Irvine, CA; $800K SBIR) up 16% [Feb 22, 21] announced that it has entered into a securities purchase agreement for the sale of $25.0 million of its common stock in a private placement. [company press release, Feb 22, 21]
Immunome (Exton, PA; one SBIR) up 76% [Feb 18, 21] biopharmaceutical company that utilizes its human memory B cell platform to discover and develop first-in-class antibody therapeutics, announced its discovery engine has isolated potent antibodies capable of neutralizing several SARS-CoV-2 variants, including the South African Variant (B.1.351), in pseudovirus testing. [company press release, Feb 18, 21]
Regenerative tissue developer Humacyte (Durham, NC: $8M SBIR) is going public through a special purpose acquisition company, or SPAC, and raising $275 million. .... The company is also pursuing work with the Department of Defense to study the vessel’s use in battlefield trauma care. [Amirah Al Idrus, Fierc Biotech, Feb 17, 21 ]
Bristol Myers Squibb is putting down up to $1.3 billion on a next-gen engineered toxin body cancer platform from Molecular Templates (Georgetown, TX; one SBIR). [Ben Adams, Fierce Biotech, Feb 12, 21]
[Rush Limbaugh] was not trying to lead people through thought but simply to divine where his followers were going and rushing to the head of the line so he could look as if he was leading them. [Peggy Noonan, WSJ, Feb 18, 21] an idea from Ghandi
Applied Genetic Technologies up 31% [Feb 16, 21] announced financial results for the quarter
Kopin (Taunton, MA; $6.4M SBIR going back SBIR start) up 25% [Feb 16, 21]
bluebird bio down 38% [Feb 16, 21] said that it was suspending marketing of its gene therapy Zynteglo, which treats beta thalassemia, and suspending two trials of another gene therapy for sickle cell disease. The suspensions came after a patient who received the sickle cell gene therapy more than five years ago was diagnosed with acute myeloid leukemia. [Barron's Feb 16, 21]
Inhibrx down 30% [Feb 16, 21]
AVROBIO down 28% [Feb 16, 21]
Hachigian and her team launched ImmuneID in 2020 using Elledge's technology. (The two had worked together previously on the launch of TScan Therapeutics, a Waltham-based cancer drug developer that raised a $100M Series C round just last month.) Hachigian now heads up the startup as CEO, and on Wednesday, the company officially emerged from stealth with $17M in seed funding. [BostInno, Feb 17, 21]
NexImmune (Gaithersburg, MD; $300K SBIR) up 49% [Feb 12, 21] after $110M IPO ; developing a novel approach to immunotherapy designed to employ the body's own T cells to generate a specific, potent and durable immune response that mimics natural biology. [company press release, Feb 11, 21]
Immunogen up 30% [Feb 12, 21] reviewed recent progress in the business and reported financial results for the quarter
Vuzix up 27% [Feb 12, 21]
II-VI made a roughly $6.5 billion bid for Coherent, setting up a seldom-seen, three-way takeover battle for the laser maker. [Wall Street Journal, Feb 13, 21]
Cyteir Therapeutics (Lexington, MA; $2,2M SBIR), a leader in the discovery and development of next-generation synthetic lethal therapies for cancer, today announced the close of an oversubscribed $80 million Series C financing. The company will use the new funds to advance its lead compound, the first-in-class inhibitor of RAD51-mediated DNA repair, CYT-0851, into phase 2 monotherapy trials in hematologic cancers and solid tumors, to initiate trials combining CYT-0851 with other cancer therapies, and to expand preclinical research to identify and advance additional novel cancer therapies. [company press release, Feb 11, 21[
You're flying on your own as CDC says it is not recommending required point of departure testing for domestic travel [CDC press release, Feb 12, 21]
The world wasn’t ready for Covid-19. [and] for the next, inevitable pandemic? ... must start by understanding that the lessons from battling Covid-19 aren’t just about Covid-19. We will fail if we learn nothing more than how to fight the last war better. ... I suggest a goal of “7-1-7”: Every country should be able to identify any new suspected outbreak within seven days of emergence, start to investigate the event within one day and report it then, and mount an effective response—defined by clear, specific benchmarks for different pathogens—within seven days. [Tom Frieden, Wall Street Journal, Feb 12, 21]
We would be riding the tiger of rapid [technology driven] change. The economy would grow faster but millions of people would have trouble finding a place in it. Universal basic income would become a red-hot topic. [David Brooks, NYTimes, Feb 11, 21] A bigger economy with higher profits and higher concentrated wealth would make a world with huge wealth at one enad and huge poverty at the other end. On the inevitable road to that end, The Trumps will gloat on the economy and markets and the Democrats will represent the bottom end, Eventually the numbers of poor with voting rights wiil demand relief. But for now the Reagan trickle-down philosophy still reigns.
They’re fine with hell, so long as they’re re-elected. [Frank Bruni, NYT, Feb 14, 21]
Law or force? A survey conducted by the American Enterprise Institute this week found that 55 percent of Republicans back the use of force as a way to “arrest the decline of the traditional American way of life,” as compared with 35 percent of independents and 22 percent of Democrats. [Lisa Lerer, NY Times, Feb 13, 21] The Republicans favoring force seem not to have read about the rise and inadequacy of Mussolini.
Zynerba Pharmaceuticals down 30% [Feb 11, 21]
Fluidigm down 21% [Feb 11, 21]
Cancer Genetics down 18% [Feb 11, 21]
Thanks in part to public investment, clean energy innovation has been fast and plentiful. The price of solar modules has declined by 99.6 percent since 1976. [David Brooks, NYTimes, Feb 11, 21]
Friends, you are the elected representatives of a great nation. The template is supposed to be Atticus Finch standing up to the crowd, not Atticus Finch endlessly sharing his retrospective terror on YouTube. [Peggy Noonan, WSJ, Feb 11, 21]
Cancer Genetics up 50% [Feb 10, 21]
Zynerba Pharmaceuticals up 47% [Feb 10, 21]
TransEnterix up 38% [Feb 10, 21]
PLx Pharma up 27% [Feb 10, 21]
PhaseBio Pharmaceuticals up 22% [Feb 10, 21]
LinQuest (Los Angeles, CA; $1M SBIR around 2006) announced that it had received a five-year contract from the Space Force worth $500 million. Under the indefinite delivery, indefinite quantity contract, LinQuest will provide analytical support to the federal agency and the other defense firms it works with [Elijah Chiland, LA Business Journal, Feb 5, 21]
Marrone Bio Innovations, maker of biologically based products to replace farm chemicals, has filed a $90 million [SEC] shelf registration statement to be able to quickly move to sell securities over the next three years. [Mark Anderson, Sacramento Business Journal, Feb 8, 21]
PDS Biotechnology (New Brunswick, NJ; $1.8M SBIR) up 53% [Feb 9, 21]
Heat Biologics (Durham, NC; $300K SBIR) up 50% [Feb 9, 21] reported positive interim data of the Company's fully-enrolled Phase 2 trial of HS-110, in combination with Bristol-Myers Squibb's (BMS) OPDIVO(R) (nivolumab) in advanced non-small cell lung cancer (NSCLC). HS-110 is an "off-the-shelf" allogeneic cell-based therapy designed to activate patients' immune system against multiple cancer testis antigens to elicit a diverse and robust immune response against tumor cells. [company press release, Feb 9, 21]
Cancer Genetics down 20% [Feb 9, 21]
Vaxart up 24% [Feb 8, 21]
news and views about government programs, politics, attitudes ...1996-1997; 1998; 1999; Y2K; 2001 , 2002-2003 ; 2004-5; 2006; 2007-08 2009-2010; 2011-2012; 2013-14 ; 2015; 2016; 2017-18; 2019-20
BMDO/ MDA including SBIR the doings of star wars
Miscellaneous Stories 1996-1997; 1998-1999; 2000-2001; 2002-2003 ; 2004-5 ; 2006; 2007 2009-2010 ; 2011-2012; 2013-2014; 2015; 2016; 2017
IPO and Venture Markets 1996-1998 .... 1999-2005 ... 2006-present
Quotes steal them if you like
Note: in these old stories, many links are dead, obsolete, or missing
Stories about companies; 1-Al .. Am-Az .. B .. C ... D-E .. F .. G-H .. I-J .. K-L .. M ... N-O ... P ... Q-R .. S1-Se .. ... Sf-Sz .. T-U .... V-Z
10 Kardiac Devices .... 10X Genomics ..... 1366
Technologies ... 1st Detect ...
21-Century Silicon ... 21st Century
Systems .... 23andMe ... 24M Technologies
... 30
Second Software ... 360fly ..... 3Bar Biologics .... 3C Semiconductor
... 3DEO .... 3D Glass Solutions ..... 3Dnamics ..... 3D
Robotics .... 3D Systems
..... 3D Technology
Laboratories
.... 3F ... 3iNanotech .... 3PrimiR ...
3Scan ..... 3-V
Biosciences
.... 3VR ... 410 Medical Innovation .... 454 Life Sciences .... 4C
Medical Technologies .... 4D Molecular Therapeutics ..... 4s3
Bioscience ... 5D Robotics
..... 65Bio ... 7AC
Technologies ... 89Bio ... 908Devices ... 9Mile Labs
A10 Networks ... A123Systems ... A4 Pharma .... A&G
Pharmaceutical ... Aastrom
Bioscience
.. Abacus Technology ... ... Abaxis .... Abcombi Sciences
..... Abcuro .... Abeona Therapeutics
..... AbGenomicsInternational ..... Abilitech
Medical ... Abiomed ... Ablative Solutions ....
Ablexis
...... ABL
Technologies .... Abpro
Therapeutics ..... AbSci .... Absorbent
Materials ... Abundant Robotics ..... AbVitro ...
Acadia Pharma ... Acambis
.. Accel Diagnostics ..... Acceleron Pharma
... Accelrys
... Accentia
BioPharmaceuticals ... Accent Therapeutics ..... Accera ....
Access Pharmaceuticals
...
Access
Scientific .... Access Vascular ... Accion Systems .....
Accumetrics
... AccuraGen ..... Accurate
Automation
.. Accuray ... Accuri Cytometers
... Acelerox ....
Acelity .... AcelRx
Pharmaceuticals ...
Acera Surgical .... Acer Thrapeutics .... Acetylon
Pharmaceuticals ... Achaogen ... Achates
Power .....
Achillion
Pharmaceuticals ... ACIST Medical Systems .... Acorda
Therapeutics
... Acorn
Cardiovascular ... Acquia .... AcroMetrix
... AcryMed ...
ActaCell ... Actasys .... ACT Biotech ... Active
Power ...
ActivBiotics
... ActivMedia Robotics .... actnano .... Acton
Pharmaceuticals
...
Actuality... Actuate
Therapeutics .... Acucela ... AcuFocus ....
Aculight
...
Acumentrics ... AcuraStem .... Acutus Medical .... Adagio
Therapeutics .... Adamas Pharmaceuticals ......
Adamis Pharmaceuticals
... Adapteva .... Adaptimmune Therapeutics .... Adaptive
Biotechnologies ..... Adaptive
Computing
... Adaptive
Phage Therapeutics ..... Adaptive TCR ... Adarza BioSystems
.....
Addiction
Therapeutix
...
Addrenex Pharmaceuticals ... Adelor ... Adenosine
Therapeutics
... Adesto Technologies .... Adeza Technologies ... Adherex
Technologies ... Adhesys Medical .... Adial Pharmaceuticals .... Adicet
Bio .... AdiMab
... ADispell ... Adlyfe .... ADMA
Biologics .... Admittance
Technologies
.... Admune Therapeutics ..... Adnexus
Therapeutics ... Adrenergics .... Advanced
BioHealing ... ADS Biotechnology ... Aduro BioTech
.... Advanced Animal Diagnostics .... Advanced Biologics ..... Advanced
Bionics
... Advanced Cell Diagnostics ... Advanced Cell
Technology (now sub to Bio-Techne) ... Advanced Ceramics
.... Advanced
Circulatory .....
Advanced Countermeasures
Systems ... Advanced Diamond
Technologies .... Advanced Electron Beams ...
Advanced Fuel
Research ...Advanced Life Sciences ... Advanced Lighting
Technologies ... Advanced Liquid Logic
...
Advanced Magnetics ... Advanced Photonix ....
Advanced
Programming Concepts ... Advanced Receiver
Technologies .... Advanced Scanners .... Advanced Scientific Concepts
..... Advanced Targeting
Systems
.... Advanced
Technology
Materials.(ATMI) ... Advanced Uro-Solutions ..... AdvanDx ...
Advantic ..... Advaxis ..... Adventrx
... ADVENT TECHNOLOGIES .... Adverum
Biotechnologies ..... Advion BioSciences
...
Adynxx ...... Aegea
Medical ... AEgis Technologies .... Aegerion Pharmaceuticals
....
Aeglea
BioTherapeutics
Holdings ..... Aerial BioPharma .... Aerie
Pharmaceuticals
... Aerin Medical ..... AerisPhotonics ...... Aerius
Photonics
... Aerodyne Research ... Aero Farms System
... Aerovate Therapeutics .... Aerovel .....
AeroVironment ... Aerpio
Therapeutics .... AesRX
...
AETC ... Aethlon Medical
... Aethon .... Aevi Genomic Medicine .....
Affectiva
.... Afferent
Pharmaceuticals ..... Affigen .... Affinia Therapeutics< .....
Affinimark
Technologies
... Affinity BioReagents ... Affinium
Pharmaceuticals ..... Affinivax .... Affomix ....
Affymax ....Affymetrix ... aFraxis ... AgBiome ..... AgeneBio
....
Agennix ... Agenovir ..... Agenus .... Agere
Pharmaceuticals ..... Agile
Materials
... Agile
Planet ... Agile RF Systems .... AgileSwitch ....
Agile
Therapeutics ....
Agility
Robotics ..... Agilis Biotherapeutics .... Agiltron...Agilvax ....
Agilyx ....
Aagios
Pharmaceuticals... AgraQuest .... Agritope... Agrivida
... Agro Biosciences .... Aguila
Technologies.....Ahura Scientific.... Aiko Biotechnology
... Aileron Therapeutics .... Aimmune Therapeutics
(formerly
Allergen Research) ..... airtricity... Airware .... Airxpanders ....
Airway Therapeutics .... ait laboratories... Akadeum Life Sciences ....
Akamai
Physics
Akarna
Therapeutics
..... Akashi Therapeutics ..... Akcea Therapeutics ..... Akebia ....
Akero Therapeutics ... Akermin ..... Akers BioScience ..... Akita
Innovations
... Akouos ....
Akrevia Thera {now Xilio Thera) .... Akron
Polymer Systems ..... Akron Surface
Technologies ..... Akros Medical ....
Alabama
Cryogenics ... Alafair Biosciences ....Albamunity .... Albany Molecular
(AMRI) ...A?
nanotech .... Albireo Pharma ..... Alcon ....
Alcresta
.... Aldagen
... Aldatu Biosciences ..... Aldea
Pharmaceuticals
... .
Alder biopharma Aldevon ..... Aldeyra Therapeutics (formerly
Aldexa Therapeutics) .... Alector .... Alexar Therapeutics .....
Alexion
... ....Alexza ....
Alfalight.... Algaeventure Systems ... Algenetix .... Algeternal
.... Algorithmia ..... Alien Technology
.... Alimera sciences.... Alios BioPharma ....Aliva
biopharmaceuticals ..... AliveGen .... Alivio Therapeutics .....
Alkermes...
Alkeus Pharmaceuticals ...
Allakos ... Allcast ....
Allegro Diagnostics ....
Allegro
microsystems ... Allena Pharmaceuticals .... Allergy Amulet
.....
Allerquest
.... Alleviant Medical .... Allied BioScience ..... Allied Minds ....
Alliqua .... Allos .... AlloVirs (formerly VeraCyte) .... Alloy
Polymers .... Alloy
Surfaces .....
Allurion Technologies ... Allylix ... Ally Therapeutics ....
Alnara Pharmaceutical
...
Alnylam... Alper Biotech ... Alphabet Energy .... AlphaCore Pharma ...
Alphamed.... Alphatec
Holdings .....
Alphavax ... Alpine Biosciences .... Alpine Data
Labs .... Alpine Immune Sciences ..... Alseres ..... Algeternal
.... Alta Devices ... AltAir Fuels ... Altair
Therapeutics
... Altamira Technologies .... AltaRock
... Altavian .... AltheaDX .... Althea
Technologies ... Altimmune .....Altis Biosystems
.... Altor ...
Altra ...
Altura Medical ... Altus Pharmaceuticals ...
ALung
Technologies
... Alvine Pharmaceuticals .... ALX
Oncology .... Alycone
Lifesciences .... Alzeca ..... AMAG Pharmaceuticals
... Alzheon ..... Amaranth Medical .... Ambarella .....
Amberwave
... Ambiq
Micro ....
Ambit
Biosciences .... AMBP
Technology ... Ambri .... Ambrx ...
Ambry .... Ambys Medicines .... Amendia .... American Bionics .....
American
Gene Technologies International .... American Lithium Energy ....
American Medical Systems ....
American Science and Engineering
... America Stem Cell, now Targagyme .... American
Superconductor
... American XTAL .. Ames
Technology ... Amgen ... Amicus Therapeutics .... Amionx ..... Amnis
...
AMO
Pharma ..... Amphivena Therapeutics .... Ampio Pharmaceuticals .....
Ampla
Pharmaceuticals ... Amplimmune .... Amplyx Pharmaceuticals
.....
Amprius .... ARMO
BioSciences .... Amunix Pharmaceuticals .... Amylin
Pharmaceuticals ... Amylyx ..... Amyris
Biotechnologies ... AN2 Therapeutics .... Anacor
Pharmaceuticals ...
Anadys
Pharmaceuticals ... Anakim Biologics ....
Analog Computing
Solutions .... Analytical Space ..... AnaptysBio
... Anavex Life Sciences .... Anchor Therapeutics ...
Ancora Pharmaceuticals
... AnDAPT ..... Anexon .... Anew Optics ... Angeion ...
AngioDynamics
... Angiologix ... Angstrom Medica .... Angstron
Materials
... Animalgesic Labs .... ANI Pharmaceuticals ...
Animetrics .... Anivax .... Anivive Therapeutics ..... Annexon
Bioscience ..... Annovis Bio .... ANP Technologies
..... Ansoft
... Ansun Biopharma (formerly NexBio) .... Antegrin
Therapeutics
..... Anthera
Pharmaceuticals .... Anthos Therapeutics .....
Antibody
Biopharm .... Antigenics ... Anue Systems ... Anulex
Technologies
... Anybots ... AOBiome Therapeutics
(formerly
Nitrocell) .... AOptix Technologies
... Aortica ..... APA
Optics (Enterprises) ... Apellis Pharmaceuticals
.....
Apexigen ... Aperiomics .... Aperion Biologics .... Aphios
... Apic Bio .... Apieron ... Apnex Medical
... ApniCure .....
ApoCell ....
ApoGen Biotechnologies .... Apollo
Diamond
... Apollo Endosurgery ... Apollomics
(previously CBT
Pharmaceuticals) .... Apoplogic Pharmaceuticals
... Applied Biomolecular Technologies .... Applied Biosystems
.... Applied Defense Solutions ..... Applied DNA
Sciences .... Applied Genetic Technology ... Applied Molecular
Transport
.... Applied Nanotech
....
Applied
NanoWorks ... Applied Optimization ..... Applied
Optoelectronics ... Applied Physical Electronics ...
Applied Physical Sciences ... Applied Precision ..... Applied
Proteomics ..... Applied Quantum Technologies .... Applied Quantum
Technology
.... Applied Research Associates
... Applied
Science and Technology ... Applied Signal
Technology
... Applied
Technology Associates .... Applied Therapeutics ...... AppThwack ....
Aprea Therapeutics .... Aprecia Pharmaceuticals ....
Apricus
Biosciences
... APS BioGroup .... Apse .... Aptalis Pharma .... Aptevo
Therapeutics .....
Aptima ... AptamiR
Therapeutics .... Aptinyx .... Aptose
Biosciences .... Aptus
Endosystems ... Aquaback Technologies ...
Aqua Bounty
... Aquacue .... AquaHarmonics ..... Aqua Metals .... AquaMost
...
Aquarius
Technologies ... Aquestive Therapeutics ....
AqueSys
... Aqueti .... Aquion .... Aradigm ....
AragonPharmaceuticals
...
Aratana
Therapeutics ..... Arbor Biosciences< ..... Arbor Biotechnologie
..... Arbor Pharmaceuticals
...
Arbovax
... Arbutus BioPharma (formerly OnCore) ..... Arca Biopharma ....
Arcadia Biosciences ..... Arcadia Pharma ..... Arcantatura...
Archemix
... Arcellx .... ArcherDX ......Arch Innotek ..... Arch
Oncology ..... Arch
Therapeutics
... Arctic Sand Technologies .... Arcturus Therapeutics ....
Arcus Biosciences ..... Arcutis Biotherapeutics .... Ardea Biosciences
...
Ardelyx .... Ardian .... Arena Pharmaceuticals
... Argentum ..... Arginetix
... Argo AI ..... ArgonST ... Argos Therapeutics ... Aria CV
...
Ariad Pharmaceuticals .. Aria Insights (previously CyPhy
Works) .... Ariosa Diagnostics ..... Arista MD
....
Arista Networks .... ARIZ Precision
Medicine .... Arkansas Power Electronics ..... Arkuda Therapeutics ...
Armadillo Aerospace
... Armata
Pharmaceuticals .... Armetheon .... ARMO BioSciences .... Armonica
Technologies .... Armorworks
... Armune BioScience ..... Aro Biotherapeutics
.... Aronora ..... Arpeggi
.... ArQule ... Arrakis Therapeutics .....
Array ... Arranta Bio .... Array Information
Technology ..... Arresto
Biosciences .... Arrien Pharmaceuticals ... Arrivo
BioVentures ..... Arrowhead Pharmaceuticals ..... Arrowhead
Research .... Arsanis ... ArsenalBio ...
Arsenal Medical
.... Arstasis ... Artel .... Arteriocyte
... Arterys
..... ArthroCare
...
Arthrosurface ... Artisan Pharma ... Artiva Biotherapeutics
.... Artizan .... Artrility
Medical ..... ArunA Bio .... Arvegenix ..... Arvinas .... Arxan
Technologies .... Aryx
Therapeutics ..... Aryx
... Arzeda
... Asana Medical (now Regentsys) .... Asante Solutions .....
Ascelegen
Therapeutics .... Ascension
Orthopedics ... Ascent
Solar Technologies ....
Ascent
Therapeutics .... AsclepiX Therapeutics .... Aseptia .... Ash
Access Technology .... Asklepios
Biopharmaceutical .... Aspinity< ...
AstroWatt .... Aspen Aerogels
.... AspenBio
Pharma .... Aspen
Neuroscience .... Aspen Products Group ....
Aspen Technology
... Aspyrian Therapeutics .... Assembly Biosciences
Assurex Health ..... Astex
Therapeutics ...
Asthmapolis .... Astralux
... Astrobotic Technology ....
Astronautics Corp. of
America ... AstroPower... AstroTerra ..
Astrum Solar ... Astute
Medical ....
Astute Medicales ... Asuragen
... Atacama ..... Atara Biotherapeutics ..... Ataxion ....
Athenex
(formerly
Kinex) ..... Atea Pharmaceuticals .... Athenen
Therapeutics ... Athenex .... Athenix
... Athens Research ..... AtheroGenics ... AtheroMed ....
Athersys .... Athira Pharma ... ATI Industrial
Automation
... Atlantia ... Atmocean .....
Atmospheric Glow
Technologies ...
Atomate ... Atomic Medical Innovations .....
Atomometrics
... Atomwise ..... Atoptix .... Atossa
Genetics
... Atreaon ....
Atreca .... Atreon Orthopedics
..... AtriCure ... Atrium
Medical ... ATRP Solutions ... aTyr Pharma .....
Audentes
Therapeutics ..... Audience
... Augmenix
.... AUM
Cardiovascular ... Aura Biosciences ....
Auris Health .... Auris Medical .... Auris Surgical Robotics
..... Aurora
Algae ... Aurora Flight
Sciences ....
Aurora
Imaging Technology ...
Aurora Spectral Technologies
... Auspex
Pharmaceuticals ... Ausra ... Auterra
.... AuthenTec .... Autolus Therapeutics .... Automated Dynamics ...
Automated
Medical Instruments .... Autonet ... Aushon
Biosystems ... AutoGenomics .... Autonomic Materials
.... Autonomic Technologies ..... Autonomous Technologies
.... Autonomous Therapeutics .... Auxilium
Pharmaceuticals ... Avalanche
Biotechnologies .... Avalyn Pharmaceuticals .... Avanir Pharmaceuticals
... Avant Immunotherapeutics ... Avanti Metal ...
Avaxia
Biologics ... Avedro ... Avelas Biosciences ....
Aveo
Pharmaceuticals
... Avery Therapeutics ..... AveXis .... Aviation Resources
Delaware .... AVI
BioPharma ... Avici Systems ... AvidBiotics
.....Avidity
Biosciences .... Avid
Radiopharmaceuticals
... Avila Therapeutics ... Avinger ....
... Aviragen Therapeutics (formerly Biota
Pharmaceuticals)
..... Aviron ..... Avisa Pharma .... Avita Medical Americas .....
Avitude .... Avrobio
..... AVT Simulation .... Aware ... Axcella Health (was Pronutria)
.....
Axelo .... Axerion Therapeutics
... Axial
Biotech .... Axial Biotherapeutics ..... Axion BioSystems
.....
Axion Power
... Axis Clinicals .... Axis
Semiconductor
... Axium Nanofibers ...... Axium Pharmaceuticals .... Axogen
.... Axonia Medical ....Axonics Modulation Technologies
Axsome Therapeutics ..... Axsun Technologies ... Ayasdi
..... Azaya
Therapeutics ... Azelon Pharmaceutical ... Azimuth
.... Azitra ..... Aziyo Biologics ..... Azure Biotech ..... AzurRx
BioPharma
Babson Diagnostics .... Baby Genes .... Bacterial Robotics
.... BacterioScan ....
Baebies ..... Bagaveev .... Ballard
Power ... Bamboo Therapeutics ..... Bandgap ... Banner Life
Sciences ..... Banyan Biomarkers ... Bardy
Diagnostics .... BarioSurg ..... Baryonyx .... Barrier
Therapeutics ... Baseload Renewables .... Basis
Science
.... Bastion
Technologies
.... Batu Biologics ..... Bauhaus Software ..... Baxano ...
Baxano Surgical .... BayoTech ..... BCD Bioscience ... Beacon
Biomedical ..... Beacon
Power ... Beam Therapeutics ..... Beat
Biotherapeutics .... Beeco
... Beeken Biomedical .... Behavioral Recognition
Systems .... Bellerephoon
Tera .... Bellicum
Pharmaceuticals .... Belmont Instrument ....
Benchmark
Automation ... BeneChill
... Benefuel ... BeneVir Biopharm ....
Bennett
Aerospace .... Benson Hill
Biosystems ..... Benvenue
Medical .... Berg .... BerrieHill
Research
... BESS Technologies .... BetaBatt
...
BetaLED ....
LEDBG Medicine
... Bettergy .... Bexion Pharmaceuticals .... Bina
Technologies .... Bind
Bioscience ... Bind Therapeutics .... BinOptics ..... BiO2
Medical
... BiO2
Technologies
...
BioAmber ... BioAdvanTek ... BioAffinity
Technologies .....
Bioanalytical Systems
... BioBehavioral Diagnostics ... BioBridge
Global
..... BioCardia .....
BioCentra Molecular Innovations ..... Biocept
...
BioChemics ..... BioClin Therapeutics .... Bicycle Therapeutics .....
Bien-Etre
Labs ..... BioCold Genesys .... Bioconnect Systems .... BioConsortia
..... BioCritica
... BioCryst Pharmaceuticals ...
BioDelivery Sciences ... Biodesix .... BioDirection ..... BioDtech ...
BioFactura ... ..... BioE ...
BioFire .... BioFluidica ..... Biogenic
Reagents
.... BioGreenChoice ... BioHaven Pharmaceuticals ..... Bioheart
...
Biohelix ... Bio-Imaging Technologies
...
Bioincept .... Biointervene .... BioIQ .... BioKier ..... Biolex
Therapeutics
... BioLife4D ..... BioLink Life
Sciences
... Biolinq (formerly Electrozyme) .... Biologics
...
BioMagnetic Solutions ....
BioMarin
Pharmaceutical
... BioMarck
Pharmaceuticals .... bioMASON ..... Biomatrica ...
BioMedical
Enterprises
... Biomedical Sciences ..... Biomedical
Structures ...
BioMedix .... Biomeme .... Biomerica .... Biometric
Signature
... BioMimetic Therapeutics
... BioMotiv .... BioNano
Genomics ... BioNanomatrix ... Bionostics
Holdings
... Bio-Path Holdings ..... Biophan Technologies
... Biophysical ... BioProcessors ...
Bioptigen
... Bioptix .... BiOptix Diagnostics ..... BioPulping
International
...
Biopure ... Biorasis ..... BioRelix ... BioResource
International
...
BioRestorative Therapies (formerly Stem Cell Assurance) ....
BioSante Pharmaceuticals ... BioScale
.... BioSense
Technologies ... BioSensics .... BioSentinel
Pharmaceuticals
... BioSig Technologies ..... Biosortia Pharmaceuticals ....
BioSphere Medical
.... Biostage (formerly Harvard Apparatus
Regenerative
Technology) ..... BioStructures .... Biosurfaces .... Biosym
Technologies later Accelrys
....
BioSystem
...
Biota Pharmaceuticals .... Bio-Techne ..... BioTechnique ....
BioTechPlex .....
Biotectix
....
Biotel
.... BioTelemetry (formerly CardioNet) ..... BioTex
....
Biothera
... BioTheranostics ... Bio Time ...
Biotix
... Biotronic NeuroNetwork ..... Biotronik ....
BioTrove
... BioVaxys .... Bioventus ..... Biovest International ....
BioVex
... BioVirtua ..... Bird Rock Bio (formerly RuiYi) .....
Birich
Technologies .... Biscayne Neurotherapeutics ..... Bitstream
... Black
Diamond Therapeutics .... Black-I Robotics
... Black Sand ... BlackThorn
..... BladeLogic
... Blasch Precision Ceramics .... Blaze
Bioscience ... Blend
Therapeutics ....
BL Healthcare ... Block Engineering ...
Bloom Energy
... Bloo Solar ..... BluDiagnostics ..... Blue Belt
Technologies
...
Bluebird
bio ...
BluDiagnostics .... Bluefin Robotics ... Bluegrass
Proteins
.... Bluegrass
Vascular
Technologies .... Blueprint
Medicines ...
BlueRock Therapeutics ..... Blue
Sky Batteries ... Bluewater Bio International ... Blue Water
Vaccines .... Bolder Surgical ... Bolt
Biotherapeutics .... Bolt Threads ....
Boom Supersonic ..... Boragen .... Boston Biochem
... Boston Biomedical ... Boston Dynamics
...
Boston Engineering ... Boston Micromachines ... Boston
Micromachines (formally Boston
Electrometallurgical .... Boston-Power
...
Boston
Therapeutics ... Bot Dolly .... Boundless
... Boundless Bio ... BoXZY
..... Braeburn Pharmaceuticals ..... BrainCells
... BrainScope .... Brain Sentry ....
Brain Tunnelgenix
Technologies .... BrainXell ..... Bra-Ket Science ... Branch Medical
Group ..... Brayton
Energy
.... Breathe
Technologies ... Breethe .... Breonics ...
BreviTest
Technologies
..... Brewer
Science ... Brickell Biotech .... Bridger Photonics .... Bridgelux
... Brightsource Energy ... Bright View
... Brilliant ...Brilligent Solutions .... Brimrose Corp of
America ... Briteseed .... Brock Rogers Surgical
...
Bromium
.... Brooks
Automation ...
Bruker Daltonics .... Buffalo BioLabs ..... Burl
Concepts ..... Burr Oak
C12 Energy ... C2Sense .... C3Nano
... C4 Therapeutics .... C8
Sciences ....
C9 ... Cabaletta Bio .... CABG Medical ....
Cadence Pharma ....
CadheRx
Therapeutics
.....
Caisson Biotech .... Calabazas
Creek
Research .... Caladrius
Bioscience ... Cala Health ..... Calando
Pharmaceuticals
... Calbiotech .... Calera ... Caliber Biotherapeutics ....
Calibra
Medical ... Calient ... California Wave Power
Technologies ..... Calimmune ..... Caliper Life Sciences
....
CaliSolar ... Calistoga Pharmaceuticals ...
Calithera
BioSciences .... Calixa
Therapeutics ... Callidus Biopharma ... Calporta
Therapeutics
.... Calspan .... Caltech Metals ... Calysta .... Calyxt ..... Cambrian
Innovation ... Cambridge
Endoscopic Devices ... Cambridge Heart
.... Cambridge
Research & Instrumentation ... Cambrios
Technologies .... CAMX ..... Candela Laser ....
Cancer
Genetics .... Cancer Prevention
Pharmaceuticals .... CanDiag .... Canopy Biosciences ..... Capesym
... Capillary
Biomedical ..... Capio Biosciences .... Capnia
... CAPP Medical ..... Capricor Therapeutics .... Cara
Therapeutics .... Carbon .....
Carbon
Design
Systems ... Carbon Engineering .... Carbtex Technology
.... Carbylan Therapeutics ..... Cardeas
Pharma ....
CardiacAssist ..... Cardiac Concepts ...
Cardiac
Dimensions
... Cardiac Science ..... Cardialen ..... CardiAQ Valve
Technologies ... Cardica
... Cardiff Oncology ... CardioDx
... Cardio Flow ..... CardioFocus ... CardioInsight
Technologies .....
Cardiokinetix ..... CardioMag ... CardioMEMS .... Cardionomic ....
CardioNXT ..... Cardiorobotics
...
Cardiosolutions ... Cardiosolv .... CardioSpectra ... CardioTech
... Cardiovate ..... CardiOx ...
Cardioxyl
Pharmaceuticals
.... CareDx (formerly XDx) .... Caribou Biosciences
.....
Carigent Therapeutics .... Carisma Thera (formerly CARMA Therapeutics)
..... Carlsme .... Carmot Therapeutics
..... Carnegie Robotics
.... Carnegie Spee .... ... .... Carnot BioSciences ....
CaroGen .... Carter Aviation Technologies .... Carticept
Medical ... Cartiva ..... Cascade Designs ...
Cascade
Microtech
... Cascadian Therapeutics (formerly Oncothyreon) ..... Casma
Therapeutics .... Castle Pharmaceuticals .... Castle Creek
Pharmaceuticals
Catabasis Pharmaceuticals ... Catadon
Systems ... Catalyst Biosciences ... Catalyst Pharma
.... Catalytic Innovations ..... Catalyze ..... Catelectric
.... Cebix .... Cedarburg Pharmaceuticals .... Cedilla
Therapeutics ..... CeeTox
... Celadon ... Celator Pharmaceuticals
... CelcuityCeldara Medical ..... Celladon .... Cellara .... Cell Care
Therapeutics ..... Cellceutix
.... CellCyte
Genetics ... Cell Design Labs ..... Celldex Therapeutics
... ..... Cellectar ... Cellerant
Therapeutics
... Celleration .... Cell Genesys ... CellRight
Technologies
..... Cellular
Bioengineering
...
... Cellular Bioengineering ..... Cellular Biomedicine Group
.....
Cellular Dynamics International .... Cell>Point
.... CellSavers ..... Cellscape .... Cellscript
..... Cell
Signaling Technology ...Cell
Therapeutics (now CTI
BioPharma)
... CellTraffix ... CeloNova Biosciences
..... Cel-Sci
.... Celsion ...
Celtaxsys ..... Celula..... Celularity ..... CellzDirect ...
Cempra Pharmaceuticals.
.... CeNeRx
BioPharma ... Censa Pharmaceuticals .... Centocor ....
Centrexion Therapeutics .....
Centrose ... Centice .. Century Therapeutics .... Centritec
Seals ... Cephalon
... Cepheid
... Cephalon ... Ception Therapeutics
... Cequent
Pharmaceuticals ... Cerebras Systems ..... Ceradyne ...
Ceramic
Tubular Products .... Ceramitron ... Cerapedics
.... Ceramatec
... Cerevast Therapeutics .... Cerealus Holdings
... Cerebral
Therapeutics .... Cerecor .... Ceregene ...
Cerahelix
.. Ceres Nanosciences ..... Cerevance .... CereVasc .....
Cerexa
.... Cerion
Enterprises ...
Cermet ... Cernostics ..... Cerulean Pharma
... Cerus ... Cervel Neurotech .... Cesca
Therapeutics .... Ceterix .... Orthopaedics ... CFD Research ..
CFX Battery
.... CGI Pharmaceuticals ... ChaCha
... Chantilly BioPharma .... Chapman
Innovations ... Charles River Analytics .... Charles
River Lab ... Charter Medical ..... Chase Therapeutics ....
CHASM
.... Chatham
Therapeutics ..... Checkerspot ..... Chemat ... Chembio Diagnostic
Systems .... ChemImage ... Chemir Analytical
Services ...
ChemoCentryx
... Chemtura ....
Chesapeake Sciences
...Chesson Labs ... Chiasma .... Chimera
Bioengineering ..... Chimerix
... Chlorogen ... Choice Therapeutics
... Chondrogenics
... Chordia
Therapeutics .... Chorum Technologies
.... ChromaCode
..... ChromaDex
..... Chronix
Biomedical
... Chrysalis BioTherapeutics .... Cibus
Global
... Cidara Therapeutics .... Ciena
....Ciencia ...
Cilion .... CimaBay Thera ..... CinCor Pharma .... CinRx ....
Ciranova
... Circle
Technologies ..... Cirius Therapeutics ..... CivaTech
Oncology ... Civetta Therapeutics .... .... CiVi Biopharma .....
Civitas Therapeutics
..... Claret Medical .... Clarassance ..... Claresta
Solutions
.... Clark-MXR ...Claros
Diagnostics
.... Clean Diesel
Technologies ... Clear Catheter Systems .... ClearCount
Medical
Solutions .... ClearEdge
Power .... Clear Guide Medical .... Clearside
Biomedical ... Cleave Biosciences ... Clene Nanomedicine
.... Cleveland BioLabs ...
Cleveland
Polymer Technologies ..... CleverSet ... Clinical Data
... Cloudant ... CloudMade ... Cloud
Pharmaceuticals
(formerly Teradiscoveries) .... Clovis
Oncology ... Clovis Tech ..... CMC Biologics .... C-Motive Technologies
.... CoAdna,Holdings ..... CoAxia ....
Cobalt Biofuels ... Cocoon Biotech .... Cocrystal
Discovery ... Coda
Biotherapeutics .... Codexis
... Co-Diagnostics< ... Codiak
BioSciences ..... Codon
Devices ... Co-D Therapeutics .... Cofactor
Genomics ....
Cogenra .... Cogentix Medical ..... Cognex
...Cognition
Therapeutics .... Cognitive Code
... Cohera
Medical .... Coherus Biosciences .... Cohesive
Technologies ... ColdQuanta .... ColdWatt ... Collagenex
Pharmaceuticals ...
Collegium Pharmaceutical ... CoLucid Pharmaceuticals
... Columbia Labs ..... CombiMatrix ...
CombinatoRx
..... Combined Energies .... Combinent
BioMedical Systems ... Comet Therapeutics .... Comfort Motion
Technologies
...
Commonwealth Biotechnologies ... Commonwealth
Fusion Systems ..... Compact Membrane Systems ...Compass
Therapeutics .... Compellent Technologies ... Compendia
Bioscience
.....
Complete
Genomics ....
Complexa
..... Conatus
Pharmaceuticals ... Concert
Pharmaceuticals
.... Concordia Fibers ...Concurrent Technologies ...
Conductus
.. Confluence Life Sciences ..... ConforMIS ...
Cognigen
.... Conispire
.... ConjuGon .. Connecticut
Valley Bindery ... COnovate ... Consonus
Technologies
... Constant Therapeutics .... Constellation
Pharmaceuticals .... Context Therapeutics ..... Contour Energy
Systems ControlRadSystems ..... Convelo
Therapeutics ....
Conventus
Orthopaedics ..... Convergen
... ConverGene .... Convio .... Convoy
Therapeutics
.... Cool-Bio
.... CoolCAD Electronics .... CoolChip Technologies
....
Cool Earth
Solar
.... Cooligy ... CoolTech .... Corbus
Pharmaceuticals
..... Corcept
Therapeutics
...
Cordex Systems .... CoreStreet ... CoreTek ...
.Corgenix
Medical
... Corindus ....Corinthian
Ophthalmic ... Corium International .... Corixa
....
CorMatrix
Cardiovascular
.... Cormedix ... Cornami ..... Cornerstone Research
... Cornerstone BioPharma then Cornerstone
Therapeutics
..... Cornerstone Therapeutics .... Coronado
Biosciences ... CorQuest Medical ..... Correx ... Corridor
Pharmaceuticals
... Cortana ..... Cortendo AB ..... Cortexyme ....
Corvidia
Therapeutics ..... Corvus
Pharmaceuticals
..... CosmosID ..... CoStim Pharmaceuticals
.... Cougar
Biotechnology ...
Coulbourn
Instruments .... Coulter Pharmaceuticals ... Cour
Pharmaceutical
Development .... Coverity ..... Creare ...
Creative
Hybrid Solutions .... Creatv MicroTech .... Cree
Research ... Crescendo Bioscience .... Crinetics
Pharmaceuticals
....
CrispTek .... Critical Therapeutics .... CritiTech
... Crossbar .... Cross Current ..... CrossFire
... Cruise Automation .... Crux Biomedical
...
CryoCor ...
CryoLife ... Cryomedical Sciences ..... Cryosa ....
Cryptonite .....
Crystal
IS
...
Crystal Systems ... Crystallume ... CSA
Engineering ... CS-Keys ... CTD Holdings
..... CTI
BioPharma (formerly
Cell Therapeutics) .... Cubist
Pharmaceuticals
... Cue Biopharma .... Cullinan Oncology ..... Cumberland Pharma ....
CuraGen ... Curamir Therapeutics ... Curative .... Current Motor
...
Curtana Pharmaceuticals .... Custom Electronics .... CVD
Equipment ..... CVRx
... CV
Therapeutics ... Cyanotech ..... Cyberdyne .... CyberKey Solutions
... Cyberkinetics Neurotechnology ... Cybernet Systems
... CyberOptics ... Cyclerion
Therapeutics .... Cydan ....
Cygnal
Therapeutics .... Cykloburn
Technologies ..... CymaBay
Therapeutics
.... Cymbet ... CyMedica Orthopedics ..... Cymer
...
Cynosure ... Cyntellect ... Cypher Genomics ... CyPhy Works
... Cypress Bioscience ... Cyrus Biotechnology .....
Cyteir
Therapeutics ..... Cyterix
Pharmaceuticals ...
CytImmune .... CytoBioScience ..... Cytocentrics ..... CytoCore
(formerly Molecular
Diagnostics) ..... Cytocybernetics ..... CytoDyn
.... Cytogel Pharma
.... Cytokinetics
... Cytometix ....CytomX ...
Cytonome
....
Cytori Therapeutics ... Cytophil CytoSolv
... Cytosorbents ..... Cytovas ... CytRx ..... Cytyc
...
CyVek
E25 Bio .... E3 Clean .... Eagle
Optoelectronics ... Earl Energy .... EarLens .... Earth Networks ....
Earthrise
Nutritionals ... eASIC ..... Eboo Pharmaceuticals .... EBR
Systems ..... Ebullient
....
Echelon .... Echodyne
..... Echogen Power Systems .... Echometrix ... EchoPixel
..... Echo Therapeutics (was
Sontra)... ECI Biotech
... ECM Technologies ..... Ecocurrent
... EcoPesticides .... EcoPro Polymers .....
Eccrine Systems ..... Ecovative
Design ... Edaptive
Computing .... Eden
Bioscience
... Edenspace
Systems ... Edge Therapeutics ..... Edico Genome .... Edison
Agrosciences ..... Editas
Medicine .... EEStor
... Effector
Therapeutics .... Egalet .... eGenesis .... Eiger BioPharmaceuticals
..... Eikos ... E-Ink
... EIS .... Eko Devices .... Ekos ... EKR
Therapeutics .... Ekso
...
Elcelyx Therapeutics ... Electrical
Geodesics ..... Electric Power Systems .... ElectroCell
Technologies
... ElectroChemical Systems ... Electro Energy
...Electromed ... Electro Optical Sciences ...
Electro
Scientific ... Electrozyme ....
Elementary Robotics ....
Elemetric Instruments
... ElevateBio .... Elevation Pharmaceuticals
... Eleven
Biotherapeutics ... Elevian .... Elicio
Therapeutics
.... Elira Therapeutics
..... Elixir Biopharm ... Elixirgen Therapeutics ..... Elixir
Pharmaceuticals ...
Ellipse Technologies ..... Elon ... Eloxx Pharma ... Elstar
Therapeutics ..... eMagin .. Embera
NeuroTherapeutics .... Embodied ....
EmboMedics
.....
Embrex ..
EMCORE
... Emendo Biotherapeutics .... Emerald BioStructures
.... Emergent BioSolutions ...
Emergent
Technologies ... EM Photonics .... Empire Genomics
.... Empire
Robotics ....
EMRes Technologies
... Emtora Biosciences (formerly Rapamycin Holdings) .... Emulate ....
Enable
Injections ...... Enanta Pharmaceuticals ..... EnChroma ..... Encite
...
Encoded Genomics .... Encoded Therapeutics .... Encompass Bioscience
..... Encore
Vision .... Encysive
Pharmaceuticals ... Endeavor Robotics ..... Endece
...
Endgame Technologies
... EndoChoice .... Endocyte ... EndoGastric
Solutions
... Endo International ..... Endoscopic
Technologies ... Endosee ..... EndoStim
.... Endotherapeutics ..... Ener1
... EnerG2 ... Energen
... Energesis Pharmaceuticals .... Energetiq
Technology ... Energid Technologies ... Energous
..... Ener-G-Rotors
... Energy Control ... Energy Conversion
Devices .
.. Energy Focus ..... Energy Materials .... Energy Recovery
... Energy
Solutions
... Energy Storage Systems ..... EnerMat Technologies .....
EnerMed ..... Enertech
Environmental ... EnerVault ... Engineered
BioPharmaceuticals
.... Engineered Propulsion ...Engineous
Software
... Enlibrium ..... Enlight
Bioscience ... EnSync Energy Systems (formerly ZBB Energy)
.....
Ensysce Biosciences ... Entasis
Therapeutics ..... Entech
... Entegrion ... Entellus Medical .....
Entera
Biotech .... Entergem Ventures .... EnteroMedics
... Entia Biosciences ..... Entira Bio .... Entopica
Therapeutics
...
EntreMed
... Entrada Therapeutics ..... Entra Pharmaceuticals
... ENTrigue Surgical ...
Envia
Systems .. Entrotech Life Sciences ..... Entvantage
Diagnostics
..... EnviroFlight ..... Envisia Therapeutics
..... Envistacom .... EnVivo
Pharma ... Enzenia ... Enzium
... Enzo Biochem ... Enzymatics ... EnzyMed ..... Enzyvant
.....
EO2
Concepts
.... EOIR
... Eonix ....
EpiBiome ....
EpiBone .... Epicentre
Biotechnologies .... Epic Sciences .... Epic Systems ..... Epicypher
.... EpiEP ...
Epion
... Epiphany Solar Water Systems .... Epitomics
...
Epiva Biosciences ..... EpiVax ... EpiWorks .... Epix
Pharmaceuticals ... Epizyme
...
Eppin Pharma .... EQRx ... EqualLogic ... Equex
... Equillium .... Equipment
Concepts ...
EraGen Biosciences ... Erallo Technologies
... Erasca .... Ercole
Biotech ... ERT ..... Escalier Biosciences BV ..... Escalon
Medical
.... E-Scape
Bio ..... Escient Pharmaceuticals ..... Escoublac
....
eScription
... eSolar ... Eso-Technologies
... Esperance Pharmaceuticals ..... Esperion
Therapeutics
..... Essential Biotechnology
..... Essential Medical .... Essentient ....
Essex... Eta Devices ..... Eta-Gen .... Etegent
Technologies
... E-Tek
Dynamics ... Eton Pharma ..... Euclid
Labs .... Euclises Pharmaceuticals ..... Eureka
Therapeutics ..... Euthymics
Bioscience ... EVapt .... Evelo
Therapeutics ....
Evena Medical ..... Ever Cat Fuels
...
Evergen Biotechnologies ... Evergreen Solar ... Everspin
Technologies .... Evestra ....
Evident
Technologies ... Evofem Biosciences ....
Evoke Pharma .....
Evolution
Robotics ... Evolv .... Evolve BioSystems ....Evolved By Nature .....
Evozyne .... EWI .... Exact
Sciences .... Exagen
Diagnostics ... Excelimmune ... Excel
Technology .... Excision BioTherapeutics ..... Exelixis .....
Exelixis
Plant Sciences ... Exemplar Genetics .... Exicure .... Exo
.....
Exogenesis
..... Exone .... Exonics Therapeutics .... Exosome
Diagnostics ..... Exovita .... Biosciences .... ExploraMed
NC4 ...
Expression
Analysis .... Exquadrum .... Exsulin
....Extreme Molding ... Extremity Innovations ... EyeGate
Pharmaceuticals ... EyeNetra .... EyeTel
Fallbrook
Technologies
... Famigo ... Faraday Pharmaceuticals .... Farodox
Energy
Storage
...
FarSounder ... Far-Tech.... FastCAP Systems ...
Fate
Therapeutics
... Fathom .... Fe3 Medical .... FEI ... Femasys
.... Femta
Pharmaceuticals
.... Ferrate
Treatment Technologies ... Ferric Contrast ...... FerroKin
BioSciences ....
Fervo Energy .... Feuz Manufacturing ... FGC Plasma Solutions
..... Fiber and Sensor ....
Fiberight ...
Fiber Materials ... Fibersense ... Fiberstar ....
Bio-Ingredient
Technologies ... Fibertek .... Fibrocell Science
... FibroGen ... Filter
Sensing Technologies ...
Finally Light
Bulb ..... Finch Therapeutics Group ..... FineLine Prototyping ....
Finisar
... Fire Alarm
Specialty Design .....
Firefly
BioWorks ... Firefly Energy .... Firefly LED
...
First Solar ... Fisker Automotive ... Five Prime
Therapeutics .... Flex Biomedical
... Flexion Therapeutics ... Flex Pharma
.... Flextronics
America ....
Flexus Biosciences .... FLIR Systems
.. FloDesign
Wind Turbine ... FlowCardia
...
FlowMedica .... FlowMetric .... Flow Metrix
...
FluGen
... Fluidic Energy ... Fluidigm ... Fluid Innovation
Group
... Fluidnet ... Fluidnet
FluoroPharma
... Fog Pharma ..... Foghorn
Therapeutics .... FokusLabs .... FoldRx Pharmaceuticals
...
Follica ...
Footnote .... Foresight Biotherapeutics .... Forest Devices .... Forge
Therapeutics .....
F-Origin
... Forma
Therapeutics ...
Formlabs
.... For-Robin ..... ForSight Vision5 .... Fortis Therapeutics .....
Forty Seven ..... Forum Pharmaceuticals ..... Forus
Health ... Foster-Miller .... Foundation Medicine
... Fox Chase Chemical Diversity Center ....
Fractal
Antenna Systems ... Fractyl Labs ..... Freedom Meditech
... Free
Flow Power ... Free Form Fibers .... Freenome ..... Froedtert
Health ..... Frontier
NanoSystems ..... Frontier Technology ..... Front Range Biosciences
.... FTL Solar
...
FuelCell Energy
... Fuel Tech
.. Fulcrum Therapeutics ..... Fulgent Therapeutics ..... Full
Spectrum Genetics .... Furiex
.... Fused
Innocation.
...
Fusion
Coolant Systems ... Future Technologies
G1 Therapeutics ..... G3
.... Gadusol Laboratories (aka
Seaceuticals) ..... Galderma .... Galectin Thera ..... Galenea ...
Galena
Biopharma
.... Galera
Therapeutics ..... Galil Medical ..... Galleon
Pharmaceuticals ... GAM Enterprises .... GameSalad
... Gamma Medica Ideas ... Garland
Technology .....
Garwood Medical Devices ..... GATR Technologies ..... Gateway
Biotechnology .... G-Con .... Gecko
Biomedical .... Gecko Robotics .... Gel Combs .... Gelesis ... GelSight
.... Geltech ...
Gema Diagnostics .... GEMFIRE .. Gemin X Pharmaceuticals
... Gemmus
Pharma ... Gemneo Bioscience ..... Gemphire Therapeutics
...... Gemstone Biotherapeutics
..... Gen9 ...
Genaera ...
Genalyte
... Genapsys .... GenAudio .... Gene by Gene .... GeneCentric
Diagnostics
... Genelabs Technologies ... Gene
Logic ... Geneoscopy ..... General Compression
... General Fluidics .... General Pneumatics
..... Generation Bio ..... Generex
Biotechnology ... Gene Security Network .... GeneSegues
Therapeutics ..... GenesisLabs ....
GeneSystems ... Genetesis .... Genetic Networks ..... Genetix
Pharmaceuticals
... GeneTx Biotherapeutics ..... Geneu .... Genia
Technologies
.... GenMark Diagnostics
.... Genoa Pharmaceuticals ..... Genocea
Biosciences
... Genomatica
... Genome Profiling ... GenomeQuest ... Genomic Health
...
Genomind ....
Genoptix
Medical
Laboratory ... Genor ... Genprex .... Gen-Probe
...
GenSpera
.... GenTel BioSciences ... GentiBio .... Gentris
... GenturaDx
...nbsp; GenVec ... GenWay Biotech ..... Genzyme .... Geocent
.... Geocove ..... Geomagic
... GeoMed
Analytical ... GeoVax Labs ...
Geospiza
... Germfalcon ..... Geron ...
Gevo
..... GI Dynamics
... GigaGen ..... GigOptix
... Gilead Sciences .... Giner . ..
Ginkgo BioWorks .. GI Windows
Medical .... Glauconix ..... Glaukos
.... GlideLine
Systems ... Gliknik ... Global Blood
Therapeutics
...... Global Cancer Diagnostics ..... Global Positions ...
Global Blood Therapeutics ....
GlobeImmune ....
Gloucester Pharmaceuticals ... Glowforge ..... GlucaGo ...
GlycoFi
... GlycoMimetics .... GlyGenix ... Glympse Bio
.... Glyscend .....
GlySens
... GMZ
Energy
... GnuBio
.... Goddard Labs .... Goldfinch Bio .....Goodman
Technologies< ..... Good Start Genetics
.... Gore
Photonics ... Gossamer Bio ..... Gotham Biotech .... Gotham
Therapeutics ..... GPC-Rx
... gRadiant Research ... Gradiant ....
GraftWorx
..... Grail ..... Graphene
Energy
... Graphenix Development .... Graphic
Surgery ... GraphLab (now Dato) .... Grassroots Biotechnology
...
Greatbatch
... GrayBug ..... Graybug Vision ..... Great Basin Scientific .....
GreatGrow Maryland ....Great North Lab .... GreatPoint Energy
... Green & Grow .... GreenFuel
Technologies .... Greenlight Biosciences .... GreenMark Biomedical
..... Green Mountain Radio
Research .... GreenSight Agronomics ..... Green Sulfcrete
.....
GreenTech America
... Greenwich Geriatrics .... Greenwich LifeSciences ...
GridBridge .... Grid
Therapeutics
..... Gritstone
Oncology
..... GRO Biosciences ..... Group14 Technologies ..... Grove
Instruments
... Grow Home Organics
.... GSI Technology ... GT Advanced
Technologies ...
GTC Biotherapeutics ... G-Tech Medical .... GT
Equipment .... GTI
Diagnostics
... GT Medical
Technologies ..... GTx .... Guardant Health .... Guided Surgery
Solutions
....
Guided
Therapeutics
.... .... Guided Therapy Systems ..... Gynesonics .....
G-Zero
Therapeutics
Energy Now ...... H2O
Score ..... H2Pump ...
H2Sonics
.... H3
Biomedicine ... HNC Software ... Halozyme ...
Hana
Biosciences .... Hansen Energy and Environmental
....
Hansen Medical ... Haplogen Genomics ..... Harbor
Technologies .. Harbour BioMed ....Hardcore Computer ...
HarkerBio .... Harmony
Enterprises ....
Harpoon Medical .... Harpoon Therapeutics .... Harvard Apparatus
Regenerative Technology .... Harrisvaccines .... Harvard Bioscience
... Harvest Automation .... Harvest Power ...
Harvest Technologies .... HDL Therapeutics .... Healionics
.. Health Diagnostics
Laboratories .... HealthMyne ....
Healthtronics
.... Hearforward
... Heartland Robotics .... HeartWare International
... Heat
Biologics .... ... HeatGenie ... Helicos
BioSciences
... Helion Energy .... Heliovolt ...
Helius Medical
Technologies ..... Helix .... HelixBind .... Helix
Therapeutics
... Helomics (formerly Precision Therapeutics)
.....
Hemadvance ..... HemaQuest Pharmaceuticals ... Hemarrest ... Hememics
Biotechnologies< .... Hemera
Biosciences .... Hemispherx Biopharma .... HemoGenyx .... Hemoshear
Therapeutics ..... HemoSonics..... Hemostasis
... Hennepin Life Sciences .... Hepion
Pharmaceuticals .... Hepregen ... Heraeus Medical
Components .... Herley Industries
... Hermemics
Biotechnologies .... Hermes Biosciences ... HexaTech
.... Hexfuel .... Hibernaid .... Highbury Defense
Group .... High Impact
Environmental
.... HighPassBio .... High Performance
Technologies ... High Point Pharmaceuticals .....
Histogen
.... HighRes Biosolutions .... Histogenics
... HistoRx
... HistoSonics .... HJM
Precision .....
HocusLocus ..... Hoku
Scientific
... Holaira .... Hollingsworth & Vose .... Hollis-Eden
Pharmaceuticals ... Holomni .... Holos .... Homology
Medicine
.....
Honeycomb Batteries .... Hontek
... Hookipa Pharma .... Hoopers Island
Oyster Aquaculture ...
Hoppe Tool
.... Hoth Therapeutics ..... HotSpot Therapeutics .... Howe
Industries .... Hsiri Therapeutics ..... HTG
Molecular ..... HTSS ... Humacyte
...
Humanetics ..... Human
Genome
Sciences ...
Human
Metabolome Technologies .... HuTerra .... Huya Bioscience International
.... Hybritech ..... Hybrivet .... HYCOR
Biomedical ...
Hydra Biosciences ...
HydroCision ... Hydrogen
Safety ... HydroLogic Industries .... Hygeia
Therapeutics
... HyperBranch Medical
Technologies ... Hyperion Therapeutics ... HyperMed
... HYPRES .. Hy-SyEnce
... HyTrust
i20 Therapeutics .... IAP ... IBC Advanced
.... iBio .... iBiquity Digital ..... Ibis
....
Iblogix
.... IBT
Laboratories
... Icagen .... Icardiac.... Ichor Medical Systems .... Iconic
Therapeutics ..... Icos.... Icosavax ... ICX....
Idaho.... Ideal
Converters ... Ideapaint.... Ideaya Biosciences ..... Idera
Pharmaceuticals ..... ID Genomics ....
Idevices
... IDx ..... iFirst Medical Technologies ...... IFM
Therapeutics
..... Igenica
Biotherapeutics .... IGM Biosciences ..... Ignyta.... Ii-IV
.... Ikaria... Ikonisys... Illinois Superconductor.... Illumigen....
Illumina.... Illuminating Diagnostics ..... Illuminoss....
Illumitex.... Imagen Energy .... Imagevision.... Imaging
Biometrics... Imagineoptix ... Imago Instruments... Imanis
Life... Imara .... Imbed Biosciences... Imetalx... Immco...
Immersion... Immtech...
Immucell .... Immucor .... Immunai .... Immune...
... Immune... Immune Pharma .... Immunetics...
Immunex...
Immunexcite...
Immuneworks... Immunexpress ..... Immunic ..... Immunicon... Immunitas
Therapeutics ..... ImmunoCellular Thera .... ImmunoChemistry
Technologies ..... Immunocore...
Immunogen... Immunome ..... Immunomedics..... ImmunoMolecular
Therapeutics .... Immunomic Therapeutics
.....
Immunophotonics ... Immurx... .... Immusant...
Immusoft ..... Impact Biomedicines .... Impact Proteomics
.... Impact Science...
Impel
Neuropharma... Imperium Renewables... Impinj... Implant
Sciences... Impossible Foods .... Imprimis Pharmaceuticals .... Imprint
Energy .... Impulse
Monitoring ... Imricor Medical Systems ..... Imris .....
Imthera... ImvaxA .... I-nalysis ... Inari Agriculture ....
InCarda Therapeutics ....
INCELL .... Incelldx
..... Incitor (now XF
Technologies) .... Incodema3D ..... Incontrol
Research... InCube Labs ..... Incyte ....Incytu... Indalo
Therapeutics ..... Indiana
Nanotech... Indi Molecular ... Industrial Heat ..... Industrial
Perception...
Inentec ... InfaCare Pharmaceutical .... Infarct Reduction
Technologies .... Infinera...
... Infinia... Infinite Electronics .... Infinity... Infinium
.... Inflammatix .... Inform
Genomics... Infoscitex... Inframat... Infraredx... Infrascan... Inf
Robotics ... Infusion Medical ... Ingeneus... Ingeneron ..... Ingenia
Therapeutics ..... Inhibitex... Inhibkase
Therapeutics .... Inhibrx< .... INI
Power... Inland Labs ..... Inmobly .... INmune Bio .... InnAVasc
Medical ....
Inneroptic...
Innerpulse... Innocrin Pharmaceuticals ..... Innography...
... Innopad... Innotec ..... Innovalight...
Innovari Energy Design Microplate Scientific...
pulmonary solutions.... silicon... Innovate Biopharmaceuticals .....
Innovative Spinal...
Innovative... Innoventiontech ... Innovention (now
Ccardiorobotics) ... Innovative Trauma or...
Innovolt ...
Innowave... ... ... Innoviva ...
Innov-x... Inocucor ..... Inorganic Specialists... Inotek...
Ino
.... Inova
Labs
Biomedical... Inovio... Inovise Medical ..... Inozyme Pharmaceuticals
..... Inphase...
... Inphi... Inpria ..... Inscripta ..... Insert MRI...
Insight...
..Insite Vision...... Insitu... InSitu
Biologics ..... Insmed... Inspired Solar Systems ...
Inspire...
Insulet
Labs
... Intact Vascular... Intaglio... Intalio ... Intarcia
Therapeutics ...
Integenx... Integra Group Diagnostics... Integral Molecular .....
Integrated BioTherapeutics
.... Integrated
Diagnostics .... Integrated
Diagnostics InDi .... Integrated DNA Technologies ..... Integrated
Fuel...
... Integration Associates... Intelect
Medical
Intelleflex ... Intellia Therapeutics .....
Intellicyt
Automation Bio-systems ...
Intelligent Devices .... Intelligent Epitaxy Technology .....
Intellimedix ..... Intelliphage.... Intellirad
Control...
.Intellisense .... Intelomed ....Inter-4... Interactive Supercomputing
... Interdigital
Interlace ....
Intermagnetics General ...Intermolecular ... Intermune....
International Stem Cell ... Interpace
Biosciences ..... Interrad Medical ..... IntersectENT ....
Intersense... Intersystems ...
Intervalve.... InterVene .... Intevac.... Intra-Cellular Therapies
.....
Intralase ...... Intralytix .... Intrepida Bio .... Intrexon .....
Intrinsic Therapeutics
.... Intrinsity....
Introgen....
... Intuitive Biosciences .... Intuitive Genomics ..... Intuitive
Surgical.... Invenra ....
Invensense .... Inventev ..... Inverness
Innovations.... Invirsa ..... Invertix.... Invictus.... Inview
Technology....
Inviragen.... Invisage Technologies ....
....InvisionHeart .... Invision Medical ....
Invitae....
Invitrogen.... ...Invivosciences.... Invivo Therapeutics=
Holdings .... Invuity....
Inx Medical.... IoGyn .... Iomai.... ... Iomed....
IOmet
Pharma ..... Ion America Optics..... Ionic Materials ..... IonQ ....
Ion
Torrent.... Iovance Biotherapeutics ..... Iovation.... Iowa Thin
Film.... IgGenix .... Ipierian.... IPG Photonics....
... Iquum
...Irhythm...
iRobot... Iroko...Ironbridge.... ... Ironwood....
... .... Irvine Sensors... .... biopolymer
. .... Ischemia Care.... iSee ..... iSIGHT
Partners
.....
Isis.... Island Ddata....
Isogenis.... Isomark.... IsoPlexis .... Isoray....
Isothermal....
Isthmus Biosciences ..... IstoTechnologies....
itaconix....
I-Therapeutix..... Itherxm Pharmaceuticals.... Itraumacare... .. Itseez
..... Itzbig ..... Iveric bio .... Iwalk
Jade Therapeutics ..... J&Y ... Janpix .... Janssen Biotech .... Janus Biotherapuetics ... Javelin Pharmaceuticals ... Javelin Semiconductor ... JDP Therapeutics ..... Jennerex ... Jnana Therapeutics ..... Joule Biotechnologies .... Jounce Therapeutics .... Joyent .... Joylux .... Joyn Bio .... Juno Therapeutics ..... Just Biotherapeutics
K2M .... K2 Therapeutics
.... KAER
Biotherapeutics .... Kala
Pharmaceuticals ... Kalion .... Kaleido
Biosciences .....
Kallyope ..... KaloBios Pharmaceuticals ..... Kalocyte .... Kalon
Biotherapeutics ..... KalVista Pharmaceuticals .... Karius ..... Karuna
Therapeutics ...
Karyopharm Therapeutics ... Kateeva
..... Kayo
Technology ..... KaZaK
... KC BioMediX ... KCI .... KDH Defense Systems
... Kebotix .... Keithley Instrument ...
Kelyniam ...
Kenall
Manufacturing
..... Kensey-Nash
... Kent Displays ... Kentucky
BioProcessing ....
KeraNetics .... Keros Therapeutics ..... Kezar Life Sciences ..... KeyW
.... Kilawatt
Technologies ... Kinaset Therapeutics .... Kindara .... KinDex ...
KindHeart ..... KineMed ....
Kinestral Technologies ..... Kineta ...
Kinetic
Concepts .... Kinex
Pharmaceuticals .... Kingbright .... Kinnate Biopharma ... Kior .....
Kips Bay
Medical ... Kite Pharma ..... Kitware ...
Kiva Systems ... KLD
Energy Technologies .... Klotho Therapeutics .... KMel
Robotics .... Knightscope
.....
Knome ...
Knopp
Neurosciences .... KNOW Bio ..... Know Labs .... KnuEdge ....
Koam
Engineering Systems .... Kodiak Sciences
.... Kolltan
Pharmaceuticals
...
Komoku ... Kona Medical .... Konarka ... Koning ...
Kopin
.. KOR
Electronics ...
Koronis Pharmaceuticals ... Korro Bio ... Kosan Biosciences
... Kosmetikos
....
Kovio ... KPI
Therapeutics (from Kineta)... Kraig Biocraft ..... Kratos Defense
& Security
Solutions
.... Kronos Advanced
Technologies ... Krystal Biotech .... KSE
... KSQ Therapeutics ..... Kultevat ..... Kura Oncology ....
Kumu Networks .... KVH
.. Kylin
Therapeutics
...
Kyma ....Kymera Therapeutics ..... Kymeta
... Kyn Therapeutics .... Kyocera
Solar .... Kypha ..... Kyras Therapeutics ..... Kyron Clinical Imaging
.... Kytopen
LAAMScience
... LaBelle
Associates .....
LabNow
...Laborie Medical Technologies ... Labrys Biologics ... Lacerta
Therapeutics ..... Lactic
Solutions ..... Laguna
Pharmaceuticals (formerly ChanRx) ..... La Jolla
Pharmaceutical
... Lake Shore Cryotronics .... Landec
.... Landos Biopharma .... Lantern
Pharma ..... Lantheus
...
Lantos
Technologies ... Lariat Biosciences .... Laser
Design .... Lasergen ..... LaserMax ..... LaserMotive
... Laser Tissue
Welding .... Lassen Therapeutics .... Lattice
Biologics ..... Lattice
Biotech .... LaunchPad Medical .... Lawrie ... Lazarus Effect
..... LDR
Holding
..... Leading Edge Crystal Technologies ..... Lead Therapeutics
... LeafBio .... LeCroy ... LED Lighting
Fixtures
... Lehigh
Technologies .... Leica Microsystems
.....
LetoSolutions .... Lexicon
Genetics
... LexaGene ..... Lexeo Therapeutics ... Lexicon Pharmaceuticals ...
Lexington
Medical .... Leuko .... Leyden Energy ... Libra
BioSciences .... LifeCell ... LifeGen
Technologies ...
Life Image ... LifeMine Therapeutics .... LifeSprout ....
Life Technologies
....
Ligand
Pharmaceuticals ....Ligon Discovery ... Lightpointe
... Light Sciences Oncology ... LightWorks Optics
....
Lilliputian Systems
.... Lily Robotics ..... Linares Management
Associates
.. Lingotek
... Linnaeus Therapeutics .... LinQuest .... Lionano .... Lion
Biotechnologies ..... Lipocine ....
LipoScience
...
Liquid Biotech ..... Liquidia
Technologies ...
Liquid Light ...
Liquid Metal
Battery ...
LiquidPiston ... Liquid Robotics ... Liquid X Printed Metals
....
LiQuifix ...
Lithium Technology
... LiveData ... . LiveLeaf
Bioscience .... LKC Technologies ... Locana.... Locus Biosciences ....
Lodo
Therapeutics .... Logical
Therapeutics
... LogicBio Therapeutics ..... Logos
Tech
... Lohocla Research
.....
Lombard Medical ..... Longeveron ..... Longeviti .... LonoCloud .....
Lookingglass ..... Loon Medical
..... Lotus Tissue
Repair
...
Loxo Oncology ... LPath Thera .... Lq3 Pharmaceuticals ....
LS9
...
Luca
Technologies .... Lucerno Dynamics .... Lucidux ...
Lucigen
.... LumaSense Technologies .... Lumena
Pharmaceuticals .... Lumen Bioscience .... Lumencor
... Lumense .... Lumera ... Lumicell Diagnostics
... Luminar Technologies ..... Luminary Micro ...
Luminex .... Luminus Devices ... Lumisyn
..... Lumitex
... LumiThera .... Lumos Pharma .... Luna Innovations
... Luna Technologies
... Lung Therapeutics .... Lutonix
... Luxtera
... Lycera ... LyGenesis ..... Lyncean ..... Lyndra
Therapeutic ... Lynntech ... Lynx Biosciences ... Lyra Therapeutics
..... Lysosomal Therapeutics ....
Lytro Therapeutics
M3 Biotechnology ....
MabVax .... MacAulay-Brown
..... Macrochem ...
MacroFab ..... Macrogenics
... Macrolide Pharma ..... Macrophage Therapeutics ....
Madison
Vaccines .... Madrigal Pharmaceuticals ..... MagBioSense ..... Magenta
Therapeutics ..... Magic Leap
..... MagneMotion ...
Magnesium Development ..... Magnetek ... Magnolia
Medical
Technologies .... Magnolia Optical
Technologies
... Magnolia Solar ... Mainstay Medical International ......
Mainstream Engineering ... Major
Pharmaceuticals .... Mako Surgical
... Mammoth
Biosciences .... Manhattan Scientifics ..... Manifold Bio .... Mantra
Bio .....
>Manufcturing Techniques ..... MapInfo
...MAP
Pharmaceuticals
... Mapp
Biopharmaceuticals .... Marathon Pharmaceuticals ..... Marcadia
Biotech
... Marina Biotech ... Marinus
Pharmaceuticals
... Maritime Applied Physics ....Marker Therapeutics ....
Marrone Bio Innovations
....
Martek Biosciences ...
MarvelBiome .... Mascoma ... Mashery
... Mason Box ... Masten Space Systems
... Masterson Industries .... Mast Therapeutics
(formerly
ADVENTRX) .... Material Sciences ... Material
Technologies ... MathStar ... Mati
Therapeutics .... Matouk
Textiles ... Matritech ... Matrix Product Development
.....Matrix
Research ....
Matrix Sensors ... Maverick Therapeutics .... MAX
BioPharma
...
MaxCyte ...... Maxdem
... Maxpower ... Maxygen ....
Maze Therapeutics .... MBio Diagnostics
.... MC10 .... MCube .... M
Cubed Technologies .... MD Biosciences ..... MDSolarSciences
... Mebias Discovery ..... Mechanical
Technology
...
Mechanology ... Medafor ...
Medarex ...
MediBeacon .... Medicago USA .... Medical21 ..... Medical Cyberworlds
.... Medical
Device Logistics ...
MedicaMetrix... Medgenics ..... MediciNova .....
Medicool
Technologies .... MedImmune ..
Medina Medical .... Mediomics .... Medior Therapeutics .... Medis
... MEDITE Group .... Medivation ... Mednology Solutions ....
Medrobotics ...
MedShape .... MedSocket (formerly 1CDS) ...... Medsphere Systems .....
MedTel ..... MEI Pharma
..... Meka .... MELA
Sciences .... Melinta Therapeutics .... Melior Discovery .... Memjet
...Memry ...
Memsic ... MEMS Optical... Mendel Health .... Menlo Therapeutics .....
MER
... Menogenix ... Mercator Therapeutics ... Mercury
Computer
Systems .... Merganser Biotech ....
Merge
Technologies ... MeriaGTx ..... Meridian Bioscience
... Meritage Pharma ..... Merkatum ... Merrimack
Pharmaceuticals
... Meryx .... Mersana Therapeutics ... Mesa
Photonics ... Mesocopic
Devices ... Metabasis ... Metabiota .... Metabolic Solutions
Development .... Metabolex .... Metabolix
... MetaCarta ... Metacrine .... Metactive Medical
.....
Metal Oxygen
Separation Technologies ... Metamark Genetics ...
MetaModix
... Metavention ..... Metompkin Seafood .... MetroLaser ...
MGC
Diagnostics
...
MIACH Orthopaedics ..... Misaole .... Micell
Technologies
... Michelman ... Micracor .... Micrel ... Microbiotix ....
MicroCoating ...
Microbe Detectives
... Microbia ... Microbot Medical ... Microfluidics International
(Microbia)
... MicroGreen
Polymers .... MicroIslet ...
Microlin Bio ....
MicroMask ...
Micronics ... Micronic
Technologies .... MicroOptical (New Mexico)... MicroOptical
(Massachusetts) ... MicroOptx ..... MicroPower Technologies
...
MICROrganic Technologies .... MicrowSat
Systems .... Microscopy Innovations ..... Microstaq
... MicroTransponder ..... Microvision ... MicuRx
Pharmaceuticals
.... Midori Renewables
..... Mid Valley
Industries
... Milestone Pharma ..... Millendo
Therapeutics (born as
Attercor) ..... Million Concepts ..... Miltec .... MiMedx Group ....
MimiVax ....
Minerva
Biotechnologies
... Minerva Neurosciences .... Minerva Surgical
.... Minimally Invasive Devices .... Minnesota
Thermal Science ..... Minnetronix ... MIOX ..... Mirador Biomedical
... Mira Dx ... MiRagen
Therapeutics .....
Miramar Labs .... Mirati Therapeutics ..... miRecule .... Mirimus ...
Mirina ... Mirna
Therapeutics.... Miromatrix Medical ...
Mirus Bio ....Mirum Pharmaceuticals ..... Mission Bio ..... Mission
Research ...
Mississippi Polymer ... Mithridion ...
Mitochon Pharmaceuticals ..... Mnemosyne
Pharmaceuticals ...
Mobile Robots ... Mobius Therapeutics ..... Moderna Therapeutics ....
Modern Meadow .... Modern Technology Solutions
.... Modis Therapeutics ..... Moduline Systems .... Modumetal .....
MOgene Green Chemicals ....
Molecular
Biometrics
... Mohawk
Innovative Technology ..... Molecular Assemblies .... Molecular
Detection ... Molecular Diagnostics .... Molecular Imprints
... Molecular Insight
Pharmaceuticals ... MolecularMD ... Molecular
Sensing ... Molecular Templates
.... Moleculin Biotech ..... Molten
Metal .. >Moma Therapeutics ..... MoMelan
Technologies ... Momenta
Pharmaceuticals ... Monebo ... Monogram Biosciences
.... Monopar Therapeutics ..... Monteris Medical
..... Morphic Therapeutics
.....
Morphormics
... Morphotek
...
Morris
Innovative Research ... Mortara Instrument ...
MortaSecurity .... Motif ... Motricity
... Motus Therapeutics .... Mound Laser
& Photonics Center ..... Movia Robotics ..... Moximed ....
mPower Technology .... MPP
Group ... MPSP ...
MSNW ....
Mudawar Thermal
Systems
.....
Munksjo Paper ... Muons ... Muse bio .... Myco
Technology
....
Myocor
... MyoKardia
...
Myomo
... Myonexus Therapeutic ..... Myovant Sciences
.....
Myriad Genetics
...
Myriant
Technologies
... Mystic Pharmaceuticals
N12 Technologies
... (N30 Pharmaceuticals) now Nivalis Thera .... NABsys
... Nalas
Engineering ....
Nammi Therapeutics ..... NanOasis Technologies
... NanoBio
...
Nanobiosym ... Nano-C ... NanoCellect (formerly NanoSort)
..... Nanochon ... Nanocomp Technologies ...
NanoCoolers ... Nanocopoeia ... NanoCor Therapeutics
...Nanodynamics (Buffalo) ... Nano DX ..... Nanodynamics
(NYC)...
NanoeXa
.... Nanofiber Solutions ... Nanogen ... NanoGraf (formery SiNode)
..... NanoGram .... nanoGriptech
..... NanoGuard Technologies .... NanoH2O ...
Nanohmics ... NanoLab
... NanoLite Systems ... NanoLogix ...
NanoLumens
..... Nanomaterials
Research
... NanoMatrix ... NanoMedex ... NanoMedicalSystems
...
NanoMedical Systems .. Nanomix ... nanoMR ..... Nanophase
Technologies
... NanoPhotonica ... Nanopore Diagnostics ..... Nanoptek
... Nanoramic
Laboratories (formerly FastCap Systems) ..... nanoRETE .... Nanoscale
Components ...
Nanoscale
Materials
... Nanoscope Technologies .... Nanosolar ...
Nanosonic ... Nanospectra Biosciences .... Nanosphere ... NanoSteel
...
Nanostim .... NanoString
Technologies .... Nanosys ...
NanoSystems ... Nano Tailor ... Nanotech Energy
..... Nanotek Instruments
.....
Nano-Terra ... Nanotherapeutics ..... NanoTune Technologies
... Nanova
....
Nanovation
Technologies ... NanoVault Medical .... NanoVibronix ... NanoViricides
... NanoVision Diagnostics .... NantCell
..... Nantero .... NantHealth ... NantKwest ..... Napo
Pharmaceuticals ... Narus
Biotechnologies ..... Nascentric
... Nastech
Pharmaceutical ... Natera .... National Technical Systems
..... Natural Molecular Testing ..... NaturalNano ...
Nature's
First .....
Natus Medical ... Naveris ... Naverus ... Navidea
Biopharmaceuticals ... Navini Networks
... Navire Pharmaceuticals .... Navitor Pharmaceuticals ....
Navmar Applied Sciences
... NBD Nanotechnologies ....NCD Technologies
.... nContact
Surgical ...
Neah Power ... Near Infinity .... Neato Robotics ... Necci
.... Nektar
Therapeutics ... Nekton
Research
.... NemaMetrix .... NeoChord ... Neogen
.... NeoGenomics ..... Neograft
..... Neoleukin Therapeutics ..... NeoLight .....
Neon Therapeutics ....
NeoPhotonics ... Neoprobe
...
Neos Therapeutics ..... NeoSync ..... Neothetics .... Neotron
...
NephroGenex .... Nereus
Pharmaceuticals ... Nest .... Netcentric .... Netezza ...
NetLogics
Microsystems... Netspeed Systems ...... Net Watch
Solutions
..... NetworkFab ... NeurAccel Biosciences ...
Neurala .... Neural Analytics .... Neuralstem .... Neuraly
..... Neuraptive
Therapeutics .....
Neuro
Amp .... Neurobiological
Technologies
...
NeuroChaos Solutions .... Neurocrine Biosciences
...
NeuroDx Development ... NeuroEM .... Neurodyne Medical ...
NeuroFlow .... Neurofluidics ....Neurogastrx .... Neurogen
... NeurogesX ...
Neurognostics .. NeuroHabilitation .... NeuroLogica
.... NeuroLutions ..... NeuroMap
... Neuro Kinetics ....
NeuroMetrix... Neurona Therapeutics .... Neuronetics .
Neuronex .. NeuroOne ..... NeuroPace
...
NeuroPhage
Pharmaceuticals
... Neuron Systems ... NeuroPointDX
..... Neuroptix
... NeuroRecovery
Technologies .... Neuroscience .... NeuroSigma .... NeuroTek ....
Neurotrack ....
NeuroTronik .... Neurotrope ..... Neurovance
... NeuroVigil ...
Neurovascular
Diagnostics ..... NeuroVision Imaging .... NeuroVista ....
NeuroVive
.... NeuWave
Medical ...Nevro ... New Dominion Enterprises ..... NewLeaf
Symbiotics .... NewLink Genetics
.... Newlink genetics england ... biolabs ...
new
era technology ... New Haven Pharmaceuticals ... Nexant
...Nexbio
... NexImmune .... NexPlanar .... NextCODE Health ....
NextCure ..... Nextio ....
NEXTracker
....Nextreme Thermal Solutions ... NextStep Robotics .....
Nexus
Biosystems ..... NFlection Therapeutics ..... NG1 Technologies .... NGM
Biopharmaceuticals .... Nico
..... Night Vision ... Nido Biosciences ....
Nimblegen Systems ... Nimble Storage .... Nimble Therapeutics
.... Nimbus Discovery ... Nimbus
Therapeutic
.....
Ninepoint
...Niowave ... NIRvana Sciences .... Nitero....
Nitric Biotherapeutics
....Nitricgen ... Nitride Solutions .... Nitrogenics ..... Nitrome
Biosciences ..... Nitromed ...Nitronex
... Nivalis Therapeutics formerly N30 Thera ..... NKT
Therapeutics ...
Nlight ... NMT Medical .... Noah
Technologies ....
Noble Fiber
... Nocion Therapeutics .... Nohla Therapeutics
.... Noivatone .... Nok Nok
Labs .... Nomadics .... NONA Composites .... Noninvasix ....
Nonvolatile
Electronics .... Nora Therapeutics .... Norian ... NorMedix
.....
Normoxys
.... Norse .... Northeast Photosciences
... Northstar Medical
Radioisotopes .... Northstar Photonics...
Northwest Biotherapeutics .. Norwich Technologies ....
Nostopharma .... Notice
Ttechnologies ... .Novacea
... Novalar Pharmaceuticals ... Novalux
... Novan
Therapeutics .... NovaScan
... Nova Synthetix .... Novatek ... NovaTorque
... NovaTract
Surgical
... Novavax .... Novazyme Pharmaceuticals ..... Novecon
Technologies ... Novella
Clinical
.... Novelos
Pharmaceuticals
... Novelos Therapeutics ... Noveome Biotherapeutic
.....
Novian Health .... Novira
Therapeutics ...
Novocell ... Novogy
... Novome Biotechnologies .... Novomer
...
Novophage ... Novo Sol-u-tions MD .... Novosource ...
Novozymes .... Novus Biologicals ....
Noxilizer
... Nox Technologies ... NP Photonics ...
NPS Pharma ..... NRGindependence ..... NSS Labs
..... Nucelis
.... Nuclea
Bioechnologies ... Nufern .... NuGEN Technologies ..... NuMat
Technologies ..... NuMedii
.... NumereX .... NUMiX Materials ..... NuPathe .... Nurel
(now PeriphaGen) .... Nurix Therapeutics ... Nuron
Biotech ... Nutrabiotix
... Nutrient Recovery and Upcycling .... NuVant
... Nuvaira .... NuVascular Technologies ....Nuvation Bio ....
Nuve .....
Nuventix ...
Nuvera Biosciences ... Nuvera Fuel Cells.. . Nuvotronics
.....
Nuvox
Pharma ..... Nu Waves ..... NxThera ... Nvision
Biomedical
Technologies ..... NZ
Applied Technologies
Oak-Mitsui .... Oasys
...
ObjectVideo
... Obsidian Therapeutics ..... OBS
Medical ... Ocarina Networks ... Ocata Thera ...
Occipital .... Ocean Bio-Chem .... Ocean Power
Technologies
... Ocean Renewable Power .... Ocera Thera .... OCI ...
Ocugen ..... Ocular
Therapeutix
....
Oculeve
... Oculogica ..... Oculus ... Oddpost
... Odyssey Systems
Consulting Group ... Oil Chem
Technologies ... OLEDWorks .... Olema Oncology .... Omega Therapeutics
.... Omeros
... OmniGene Bioproducts ... OmniGuide ...
OmniLytics
... Omniox ..... OmniSonics Medical Technologies
... Omnis
PharmaRebiotix .... Omni
Water Solutions ... Onboard Dynamics .... ONCE Innovations
.....
OnChip
Power .... Oncobiologics .....
Oncoceutics ... OncoCyte
.... Oncogenex
... Oncolmmune ..... Oncolinx .... Oncolix ..... Oncolytics
Biotech
...
OncoMed
Pharmaceuticals .... OncoNano Medicine .... Onconova
Therapeutics
...Oncoscope
...
OnCore Biopharma ..... OncoResponse ..... Oncorus .....
OncoSec
Medical
.... OncoTartis ...... Oncothyreon
... Oncovista Innovative Therapies ..... Oncternal
Therapeutics ... Onduo ..... One
Resonance Sensors .... Onexio Biosystems .... Onko Solutions ....
OnKure Therapeutics ..... ONL
Therapeutics .... OnLume ....
On-Q-ity .... Onspira Therapeutics .... On Target
Laboratories
.... Ontela ..... On-X
Life
Technologies ....
Onyx
Pharmaceuticals ... Oorja
Protonics .... Open Algae ... Open Monoclonal Technology
.....
Open Silicon
... OpenWater
Power .... Opertech Bio ..... Opexa
Therapeutics
... OpGen ... OPNET Technologies
... Opsonix .... OptTek
Systems ... Optelecom ...Optelecom-NKF ... Optherion ...
Optical
Concepts .. Optigain .. Optimal Technologies ... Optimus
Technologies .... OptiNose .... Optivision
...
Optofluidics ... OptoLum ..... Optonicus .... Opto Technology
...
Optomec
....
OPX
Biotech
... Oragenics .... OraMerix
... Orasi Medical ... OraSure
Technologies .... Orbital Insight .... Orbital Sidekick ... Orbital
Technologies
... Orbotix .... Orca Bio .... Orchard Therapeutics
.....
Orchestra BioMed .... Orchid
Cellmark
... Oregon Iron
Works .... Orexigen
Therapeutics
... Organic Research .... Organogenesis ...
Organovo
..
ORIC Pharmaceuticals ..... Oricula Therapeutics .... Origin
Medsystems ..... OriginOil
... Orion Energy Systems ... Orion Genomics ...
Ormet
Circuits ... Oroboros Bio .... Orologic...
OrphoMed ..... Ortel ...
OrthoAccel
Technologies ... Ortho Kinematics
.... Oryx Technology ... Osazda Energy ... Oscient
Pharamceuticals ...Oscilla
Power
.... Osiris
Therapeutics ... OSI Pharmaceuticals ... Oso Biopharmaceuticals
Manufacturing .... Osprey Medical ....
Ossianix
... OSSIO ..... Ostendo Technologies ...
Osteotech ... Osterhout Design Group .... OtoNexus Medical
Technologies .... Otonomy .... OtoSense
.... Ottomatika .... Outset Medical .... OvaScience ...
>Ovid Therapeutics ..... Oxalo Therapeutics .... Oxford
Performance Materials ... Oxis International .... Oxygen
Biotherapeutics ... Oyster Point Pharma
P3I ... Pace Packaging
.... Pacific Biosciences
.... Padlock Therapeutics .... Pain Therapeutics ...
PaizaBio .... Palvella Therapeutics ... Palantir Technologies ....
Palleon Pharmaceuticals ....
Palmaz Scientific ..... Palmer
Labs
...
Paloma Pharmaceuticals ... Panacea Solutions ....
Panacos
... Pandion ..... Pandromics ..... Pan Genome Systems .... Panomics
..... PanTheryx .... Paper
Battery ....
PapGene .... Parabricks .... Paradigm Diagnostics
.... Paradigm Sensors
... Paradromics ..... ParaGen Technologies ..... Paragon
Bioservices ..... Paragon Dynamics .... Paragon Space
Development ...
Paragonix Technologies .... Parasol Therapeutics
... Paratek
Pharmaceuticals .... Parexel International .... Parhelion .... Parion
Sciences
... ParkerVision .... Partner Therapeutics ..... Partpic ....
Passage Bio ... Passport
Systems ... Pasteuria Bioscience ... Pathfinder ...
PathoGenetix
... PathoVax ..... Pathway Genomics .... PatientStream ...
PatientWise ...
Patton Medical Devices ... Patton Surgical .... Pavilion
Technologies ... Pax Streamline ... PaxVax ...
PDI Therapeutics ..... PDL
BioPharma ... PDS Biotechnology ..... Pearl
Therapeutics
... Pear Therapeutics ..... PECA Labs
.... Pediatric Bioscience .... Peerless Technologies .... Pegasus
Sustainability Solutions ....
Pelican
Products ..... PellePharm .... Pellion
Tech ... Peloton Therapeutics ..... Peninsula
Pharmaceuticals ..... PennAlt Organics ..... Penumbra .....
PeproMene Bio .... Peptimed
... Peptilogics .... Peptimmune
... Perceptive Navigation ..... Perceptive Sciences
... Perceptron ....
PercipEnz
Technologies
... Peregrine Semiconductor .... PeriphaGen .... Permeon
Biologics
...
Perosphere .... Perscitus Biosciences ... Perseon .....
Persimmon
Technologies ....
PersonalBee ... Personalis ...... Personal Genome
Diagnostics
.... Pervasis Therapeutics
... Pervasive
.... Petra Pharma ..... Pfenex ...
Pharmacyclics
.... PharmaJet .... PharmAkea Therapeutics ....
Pharmasset
... PharmAthene
... PharmatrophiX .... PhaseBio
Pharmaceuticals .... Phase Bioscience ... PhaseRx ....
Phigenix
..... Phoenix (formerly Phoenix Nuclear Labs) ..... Phoenix Analysis
and Design Technologies ..... Phoenix
Biotechnology .... Phoenix Molecular Designs .... Phoenix
Nuclear Labs ...
Phio Pharmaceuticals .... Phoenix Science
.. Phononic
Devices
... Photobit ... Photolitec .....
PhotoMedex
... Photonics
Innovations ... Photon-X ....
PhotoniCare .... PhotoSonix Medical ....
PhotoThera
...
Photronics ... Phoundry Pharmaceuticals .... Phraxis
.... Phrixus
Pharmaceuticals ..... Phurnace
Software ... PhylloTech ..... Phylonix
.... Phylos Bioscience ..... Physcient .... Physical
Optics... Physical
Sciences
... PhysioGenix
... PhysioSonics ... PhytoTech ... Picolight ....
Picometrix
... PIC Therapeutics .... Piedmont Biofuels .... Pieris
Pharmaceuticals ..... Pika
Energy ... Pilus
Energy ....
Pinger
...
Pinnacle Technology ... Pioneer Surgical
Technology .... Pionyr Immunotherapeutics ..... Pivot
Bio ..... Pixelligent .... Pixel
Optics .. Pixim ... Pixtronix ... Plakous Therapeutics .....
Planar Energy
...
Planar Systems ... Planet Labs .... Plano Microwave ..... Plasan ...
PlasmaTech Biopharmaceuticals .... Platelet
BioGenesis .... Platypus
... Play-i
.... PLC
Medical Systems
... Plextronics ... Plexxikon
... Pliant Therapeutics .... Plug
Power ... Pluromed ... Plus Therapeutics .... PLx Pharma
..... PLX Technology ....
PMT
.... PMV Pharmaceuticals .... PneumRx .....
Point Source .... Polarean ..... Polatis
.... Polychromix
...
Polyera ... PolyMedica ... PolyMedix ...
PolymerPlus ... Polymer
Technology
Systems ... Polynoma ..... PolyNova .... PolyPlus ... PolyRemedy ...
Polysciences ... Polystor ...POP
Biotechnologies .... Portola
Pharmaceuticals ... Poseida Therapeutics .... Possis
Medical ... Pothole Pros ... PowerGenix ...
Powerlight
... Power
Precise Solutions ... PowerVision ... Pozen ... PQ
Bypass .... Prairie
Technologies ..... Pranalytica ... Praxis Biotechnology .....
Precipio ... Precision Biopsy
... Precision BioSciences
.... Precision for Medicine .... Precision Genome
Engineering .... Precision Ocular Metrology ..... Precision Optics
...
Precision
Therapeutics (now Helomics) .... Precision Virologics .... Precisive
Surgical .... Predictive
Biosciences
... Pregmama ..... Prellis Biologics .... Prelude
Therapeutics ... Presage Biosciences
... Presidio
Pharmaceuticals
.... Pressure BioSciences
... PreTalen ..... Prevail Therapeutics ..... Preventice .....
Prevention
Pharmaceuticals ....
Prieto Battery ..... Primary Data ..... Primera
Biosciences ... Primordial .... Primorigen Biosciences
... Primus Power .... Princeton Satellite
Systems ..... Principia Biopharma ....
Prism
Solar Technologies .... Procept BioRobotics ..... ProCertus
BioPharm
... Processa Pharmaceuticals .....
Proclara
Biosciences (formerly
NeuroPhage
Pharmaceuticals) .... Procyrion .... Profectus BioSciences .
.. Progenics
Pharmaceuticals
... Progenity .... Progeny Systems ..... Prologic
...
Promedior
...
Promega ..... Promentis .... Prometheus Laboratories
.... PROMISS
Diagnostics ...... Pronutria ..... Propagenix ..... Propeller
Health .... Propulsive Wing .... ProstaGene ....
Protagonist
Therapeutics .... Protein Foundry ..... Protein Sciences
... ProteinSimple (formerly Cell
Biosciences) .... Proteon Therapeutics
...
Proteostasis
Therapeutics
... Proteotech ... Proteus
Biomedical
... Proteus Digital Health .... Protez Pharmaceuticals
.... Prothena .... ProThera Biologics ...
Proto Labs ... Proton Energy Systems ...Protonex ..
Prototype
Productions .Provagen ... Provenance Biopharmaceuticals
... Provention Bio .... Proventys
... Provista Diagnostics .... Pryor Medical Devices .....
PsiKick
..... pSivida
... PTC Therapeutics
.... Pulmatrix ... Pulmonx .... Pulmotect ..... Pulse
Aerospace .... Pulse
Electronics ....
PulseTherapeutics .... Puma Biotechnology ..... PUR
Biologics ..... Pure Bioscience .... Purfresh
... Purillume ..... Purinomia Biotech .... Pursuit
Vascular ... PurThread
.... PvP
Biologics ..... Pylum Biosciences ... Pyramid .... Pyran ... Pyxis
Oncology
Q32 Bio .... Qcept Technologies ....
Qcue .... QD Vision
... QED ... qFuzion ..... Qioptiq
... QM Power
... Qpex .... QPixel ... QR
Pharma
... QSpex .... Qteros
... QuaDPharma .... Quadra-Aerrow International ...
Quadraspec
...
Quad Technologies .... Qualcomm ... QualityMetric
...
Qualtech Systems ....
Qualtré ... Quanterix
... QuantRx Biomedical
.... Quanttus .... QuantTera .... Quantum Circuits ..... Quantum
Epitaxial
Designs ... Quantum Fuel Systems... Quantum Logic
Devices
... Quantum Materials .... QuantumSphere
.... Quantum Xchange .... Quark
Biotech ... Quark
Pharmaceuticals ... Qubitekk ..... QQuench Bio .... Quentis
Therapeutics .....
Quick–Med
Technologies .... Quid ..... Quidel
... Quincy
Bioscience
... Quintessence Biosciences ... Quorum
Systems QurAlis
Radant Technologies ... Radiabeam Technologies
... Radiance Technologies .... Radiant Photonics...Radiation
Monitoring Devices
... RadioMedix ... Radius
Health ....
Rafagen ... Rainbow Organic Farms ... RainDance
Technologies
...
RainStorm ...
Rain Water Solutions ... Rallybio ..... Raland Therapeutics .... RaNA
Therapeutic ...
RAN Biotechnologies .... Range Fuels
... Rapamycin Holdings ..... RaPharmaceuticals
... Rapid Diagnostek ... Rapid
Micro Biosystems
... Rapiscan ... Rapt Therapeutics ... RareCyte
..... Raser Technologies
.... Raydiance ... Raydiant Oximetry .... Raymond
.... Raze
Therapeutics
.... RE2
.... ReadCoor ..... Ready Robotics ..... ReAlta Life
Sciences .... Reata Pharmaceuticals ....
Rebellion
Photonics .... Rebion ..... Rebiotix ....
Receptor Logic ...
Receptos
..... Recodagen ... ReCode
Therapeutics .... Recombinetics
... ReconRobotics
.. Recovery Engineering ..... Recro Pharma ....
Recursion
.... Redox Power
Systems .... Redpin Therapeutics .... Red Rock Biofuels .... RedShift
BioAnalytics .... Redwood Robotics .... RedZone
Robotics .... RefleXion
Medical .... Refuge Biotechnologies .... Regado
Biosciences
... ReGear Life Sciences ..... ReGen
Biologics ... Regenerative
Medical Solutions ..... Regenerative Sciences ... Regentys
(formerly Asana Medical) .... Regenxbio
....
Regulus Therapeutics ... Rehabtics .... Relativity Space ....
Relay Therapeutics
..... ReliantHeart ....
ReliefBand Technologies ..... Relievant Medsystems
..... Relypsa .... Remedy Plan Therapeutics .... Remedium
Technologies ... RemoteReality .... Rempex
Pharmaceuticals .... Renaissance Services ..... Renegade
Materials .... Reneo
Pharmaceuticals ..... Renerva ..... ReNeuroGen .... Renewable
Alternatives
... Renewable Energy Group .... Renmatix .....
Renovacor
..... RenovoDerm ..... Renovia .... Renovion .... Renovis ...
Rentech ... Repare Therapeutics .... Replidyne
...
Repligen .. Replimune Group .... Reprieve
Cardiovascular .... Research Frontiers
.. Research Innovations ..... Resolve
Therapeutics
... Resolvyx
Pharmaceuticals ... Resonetics ..... Respicardia
... Respira
Therapeutics .... Response Genetics
...
Restoration Robotics ..... resTORbio ..... Restore Medical ... Retectix
..... Retek
...Rethink
Robotics ... Retia Medical .... Retriever
Technology
.... Retrophin< ... RetroSense Therapeutics .....
Revacom ... Reva
Medical
... Revance Therapeutics Pharmaceutical ....
Revegen
... ReVision Optics ....
ReVision
Therapeutics .... Revitope Oncology ..... ReVivo Medical
....
RevMedx .... ReVolt Tech
... Revolution
Medicines .... ReWalk
Robotics (Israel) .... Rexahn
Pharmaceuticals
... Rex Computing ..... RF Code ...
RFMicron
.. RFS Pharma ..... RF Surgical.
.... Rgenix .... Rgenta Therapeutics .... Rhenium
Alloys .. Rheos Medicines ..... Rheostat
Therapeutics ..... Rheumco .... Rhevision
... Rho ... Rhythm Pharmaceuticals ... Rhythmia
Medical
... Ribometrix ....
RiboNova .... Ribon Therapeutics ..... Rib-X
Pharmaceuticals ... Rice Technology ..... Ridgeback BioTherapeutics
.... Ridgetop
Group ... Rigel Pharmaceuticals .... RightEye ..... RightHand
Robotics .... Rinat
Pharmaceuticals
.... Rinovum Women’s Health ..... Rio Grande Neurosciences .....
RipCode ... Rite
Solutions .... Ritter
Pharmaceuticals ..... River Vision Development ..... Rive Technology
... RJA Dispersions ... R.L. Phillips ...
RMH
Sciences ...
Robb Surgical Devices .... Robopsy ...
Robotic FX ... Robotics VISION
Technologies ..... Robotic Research .... Robotic Technology
... Rocket Pharmaceuticals .... Rockwell Medical
..... Rocky Research .... Rodeo Therapeutics ..... Rodin
Therapeutics ... Roka
Bioscience
.....
RoosterBio .... RootPath .... Rosina Food Products ....
Ross Valve ..... Rotational
Medical .... RotoMetrics ..... RoverMed Biosciences ..... Rowbot
Systems .... Royole ..... RQx
Pharmaceuticals .... RRE
Solar ....
Rubicon Tech ...
Rubigo Therapeutics .... Rubitection ..... Rubius Therapeutics ....
RubrYc Therapeutics ..... Rules-Based
Medicine
... Rushford Hypersonic ... Ruud Lighting ..... RxFunction
...
RXi Pharmaceuticals
...
RxMedic .... Rypos
S2 ... Sadasis
.... SafeShot .... Saffron
Technology
.... Sage
Electrochromics ... SADAR 3D .... SafeLi .... Sage Science
... Sage
Therapeutics ... Sakti3 ... Salarius
Pharmaceuticals .....
Salient Surgical
Technologies
... Salix
Pharmaceuticals ... Salutaris Medical Devices ..... SAM Medical ....
Sancilio
Pharmaceuticals .... Sand 9 .
.. Sandia Biotech .... Sangamo
Biosciences
... Sangart
... Santalis Pharmaceuticals ..... Santarus .... Sanuwave
Health
.... Sapheon .... Sapphire
Energy ....
SARbarcode .... Sarda
Technologies ...
Sarepta Therapeutics .... SatCon
Technology ...
Satori Pharmaceuticals ... Satsuma Pharma
.... Savara Pharmaceuticals .... Savi ...
SBH
Sciences ...
Scanadu ..... Scholar Rock .... Sciaderm ..... SciClone
Pharmaceuticals
... Sciencescape ..... Scientific
Conservation .... Scientific Research ...
Scientific
Solutions ... Scientific Systems ... SciFluor Life Sciences ... Scilex
Pharmaceuticals .... Scinovia ..... Scioderm .... Scion Plasma ....
SciQuest ...
Scopic Software ... Scopus BioPharma ... Scorpion
Therapeutics .... Scout Bio
....
scPharmaceuticals ..... Scribe Therapeutics
.... Scynexis ...
SD Catalyst
Group ... SDL .. SeaChange ...
Seacoast Science
... Seahawk Biosystems ... Seahorse
Bioscience
... Seaside Therapeutics .... Seattle BioMed .....
Seattle
Genetics
...
Seattle Medical Tech .... Sebacia .... Second Genome ....
Second
Sight Medical
Products ... Securboration ..... Secure
Computing ... Sedia Biosciences ..... Seeo
....Segetis ... S.E.G-WAY Orthopaedics .... Seldon
Labs ... Selecta Biosciences
... SELLAS Life Sciences Group .... SeLux
Diagnostics .... Sema4
Natalis
..... Semiconductor
Laser ... SemiProbe ... Semler
Scientific
.... Semma Therapeutics .... Semnur
Pharmaceuticals .... Semprius ... Semprus
BioSciences .... Sencera International ...
SenesTech .....
SenGenix ....
Senior Scientific ..... Seno Medical
Instruments .... Senomyx
... SensAble Technologies ... Sense .... Sense
Diagnostics
....
Senseonics ..... Sensintel .... Sensiotec ...
Sensors
Unlimited
... SensorTran ... Sentelligence
... Senti Biosciences ..... Sentient
Technologies ..... SentreHEART ..... Sepracor
... SeprOx .... SeQual Technologies ... Sequella ...
Sequel
Pharmaceuticals .... Sequenom ... Sequenta ...
Sequent
Medical
.... SeraCare Life Sciences ... Seragon
Pharmaceuticals .... Seraxis ..... Seres Therapeutics (formerly Seres
Health) .... Serenex
... Serionix .... Sermonix
Pharmaceuticals .... Servergy .....
SetPoint Medical .... Seurat Therapeutics ..... Seventh Sense
Biosystems ...
SGB
Biofuels ..... SGX
Pharmaceuticals ...
Shamrock Energy ... Shape Pharmaceuticals ..... Shape Security ....
Shapeways .... Sharklet
Technologies ..... Sharp Edge Labs ..... Sherlock Biosciences
Shift Labs ..... Shift Pharmaceuticals ..... Shiloh
Labs ....Shine
Medical Technologies
... ShiraTronics ... Shore
Thing Shellfish .... Shuttle
Pharmaceuticals ..... Siamab Therapeutics .... Si-Bone ....
Sicel Technologies ...
SiCortex
... Sideris Pharmaceuticals ..... SI
Diamond Technology .... Sienna Biopharmaceuticals ..... Sierra Energy
..... Sierra Monolithics
... Sierra Nevada ...
Siga Technologies ...
SiGe Semiconductor ... Sigilon Therapeutics ....
Sigma Labs
(NM) .... Sigma
Technologies .... SignalFX (formerly Signal Fuse) ..... Signal Genetics
.... Signature
Genomic Laboratories
... Sila Nanotechnologies .... Silarus Therapeutics
.... Silatronix ..
Silent
Power ... Silicon Biosystems Menarini ..... SiliconBlue
....
Silicon Laboratories ...
Silicon
Mountain
Design .. Silicon Space Technology .... Silk .... SilkTech
Biopharmaceuticals ..... Silk Tech .... Siluria
... Silverbrook
... Silverback ..... Silvergate Pharmaceuticals .... Silver
Spring Networks
... Simbol Materials ... Simcha Therapeutics ... Simply
Incredible Foods ... SiMPore
...
Simulation
Technology and Applied Research ... Simulution
... Singlera Genomics ..... Singulex ... Sinmat
... SiNode Systems .....
Sintact Medical Systems
..... Sion
Power
... SiOnyx ... Sioux Manufacturing ...
Sirga Advanced
Biopharma .... Sirion Therapeutics ...
Sirnaomics ..... Sirna
Therapeutics ... Sirtris Pharmaceuticals ... Sisu Global
Health
..... Sitari Pharma .....
Skybox Imaging .... Skyhawk Therapeutics ..... Skyline Medical
....
Skyonic
... SLI .. SLIPS Technologies .....
SmartCells
... Smart Modular
Technologies ... SmartSpark Energy Systems ...
Smart
Structures .... Smart Wires ..... SmartZyme BioPharma ....
Smisson-Cartledge Biomedical ...
Smooth-Stone
...
SNP Bio ..... Socrates Health Solutions .... Sofregen ....
Soft Machines
....
Soft Robotics ..... SoftSwitching
Technologies
... Soft Tissue
Regeneration ... Soladigm (now View) ..... SolAero
Technologies ..... Solaicx ....
Solais Lighting
....
Solana Surgical ..... SolaranRx ..... SolarBridge
Technologies ... Solar Connection ....
Solarea .....
Solaria ...
Solarmer
Energy ...
Solar Power Technologies ... SolarWinds
... Solazyme
... Solexant ... Solexel ... SolFocus ... Soliant
... Solid Biosciences .... Solid Concepts ..... SolidEnergy
....
Solidus Biosciences
..... SolidWorks
... Soliris .... Soliton ..... Solixia
... Solix
Biofuels
... SolMap
Pharmaceuticals ... SoloHealth ... Solomon
Technologies
... Solo Power .... Solstice Biologics .... Soluble Therapeutics ....
Solx ....
Solyndra ... Soma .... SomaDetect .... SomaLogic
.... Somatic Labs ..... Somatus ..... Somaxon
Pharmaceuticals .... Somerset Therapeutics .... Somna Therapeutics ...
Sonalysts ....Sonavex .... Soneter .... Sonex Aircraft ... Sonitus
Medical
... Sonivate ..... SonoSite
... Sonovex .... Sontra Medical ... Sonus
Pharmaceuticals
...
Sophiris
Bio .... Sophono ..... Soraa .... Sorrento Therapeutics ....
Soteira
... Sostena .... Sotera Wireless ... Sound Pharmaceuticals
.....
Sourcefire
... Source MDx
... Southwall Technologies ... Southwest Windpower
...
Space Dev ...
Spaltudaq ... Spansion .... Sparkbuy ..... SparkCharge .... Spark
Therapeutics ....
Sparo Labs .....
Spatial Photonics
...
SPEC ..... Spectra254 .... Spectragenetics .... Spectral Energies .....
Spectral
Systems .....
Spectranetics ...
SpectraWatt ... Spectro Coating ... SpectrumS4 ....
Speech
Tails ... Speer Medical .... Spero Therapeutics ..... Spinal
Modulation ..... Spinal
Restoration
... Spinal Simplicity ..... Spinal
Stabilization Technologies ..... SpineEX .... SpineGuard ...
Spineology
... Spine Wave .. Spintech .... Spin
Transfer
Technologies ....
SpiralGenetics .... Spiral Therapeutics .... Spiration
... Spire
... Spirox (formerly Nasoform) ..... Spoonflower .... Spotfire ... Spot
On Sciences ...
Spredfast
... Spring Bank Pharmaceuticals ... SpringLeaf Therapeutics
... SpringWorks .... SpringWorks Therapeutics ....
SPR Therapeutics
.... Spyrix ....SQZ
Biotech ..... SRL ... Staktek Holdings ... Standard
Bariatrics .... STAR Cryoelectronics
... Starfire ... Startech Environmental
... Startup Circle Pharma .... StarVision
Technologies .... Stasys Medical ..... SteadyMed Therapeutics
..... Stealth BioTherapeutics ..... Stealth
Therapeutics ... Steel City Optronics ....
Stellaray
.... Stellar Biotech .... Stellar Science ....
Stellent .... Stemagen ... StemBioSys .... Stem Cell Assurance (Now
BioRestorative Therapies) .... StemCells
... Stemcentrx ..... StemCo
Biomedical ... Stemgent ...
StemImmune ....
Stemina Biomarker
Discovery ... Stemonix ..... Stem Pharm .... Stereotaxis ...
Sterilmed ...... Sterling
Semiconductor ..... StimMed ..... Stirling Energy .... Stoke
Therapeutics ..... Stottler
Henke ... Straight Flight .... Stratagene ... Strata Oncology
..... Stratasys
... Stratatech
... Strategic Response Initiatives .... Stratos
Genomics
... Strella Biotechnology ..... StrideBio ....
Stromedix ....
Strongbridge
Biopharma .....
Sucampo Pharmaceuticals ..... Summit
Technology
.... Sun BioPharma ..... Sun Catalytix
.... Sunesis
Pharmaceuticals
.... SunHealth Solutions ... Suniva ....
Sunovion
Pharmaceuticals
... SunPower ... Sun Power Biodiesel ...
Sunrise
Ridge Algae ....Sunshine Heart .... Suntech ...
Sunvapor .... Suono ..... Superconductive
Components ... Superconductor Technologies ... SuperDimension ...
SuperFlex ..... Superior
Organoid Technologies ..... Supernus
Pharmaceuticals .... SuperPower ... Superprotonic
.... SupraSensor .....
Surefire
Medical
.... Surface
Logix
... Surface Oncology ..... Surgient ...
SurgiQuest
.... Surmet
... SurModics ... Suro Biopharma .....
Suros Surgical Systems
..... Surrozen .... SURVICE Engineering ..... Sustainable
Bioproducts .... Sustainable Oils ....
SustainX ... Sutro Biopharma ..... Sutron .....
SutroVax ..... SuturePro
Technologies (now Ceterix) .... SuviCA .... SuVolta ... Suzlon Rotor
... SVS
... SPEC ... Swallow Solutions .... SweetSpot Diabetes Care
... Swift Biosciences .... Swift Coat ..... Syagen Technology
... Symbiomix Therapeutics ..... Symbiont Web
...
Symbotic ...
Symetrix .... Symic Biomedical ..... Symyx
Technologies
... Synack .... Synageva BioPharma ... SynAm Vaccine
....
SynapDx
....
Synaptics ... SynCardia Systems ..,.. Synchroneuron ....
SynchroPET .... Syndax
Pharmaceuticals
... Syndexa Pharmaceuticals .... Synedgen ....
Synergy
Biomedical
....
Synergy Pharma ..... SynGen .... Synlogic ..... Synopsys .... SynSonix
.... Synta
Pharmaceuticals ... Syntax-Brillian ... Synthekine
.... SyntheMed
... Synthetic Biologics ..... Synthetic Genomics
.... SyntheZyme .....
Synthorx ....
Syntimmune ..... Syntrix
Biosystems .... Syntronics .... Synvitrobio ..... Syros
Pharmaceuticals .... Sysgain .... Syslogic .... Systagenix Wound
Management .....
Systems and Processes Engineering
SPEC ... Systima Technologies ..... Sytera
T2
Biosystems ... T3D Therapeutics ..... Tabula ... Taconic
BioSciences ..... Tactical Engineering and Analysis ..... Tactile
Systems
Technology .... Tactiva Therapeutics ..... TAI Diagnostics .....
Talaris Therapeutics .... Talecris Biotherapeutics
... Talee Bio ..... Taligen Therapeutics
...
Talima Therapeutics ... Tal Medical ... Talon Therapeutics
... Tandem Diabetes Care ...
Tangen Biosciences
..... Tango
Therapeutics ..... Tanox ..Tantaline
.... TapImmune .... Tarari ...
.Targacept ...
TargeGen
... Targ-Anox ... Targanta
... Targazyme (formerly)America Stem Cell....
Targeson
... Targeted Genetics ... Targeted Growth
... Taris Biomedical .... Tarveda Therapeutics
..... Tascent .... Tauriga
Sciences
.... Taxa Biotechnologies ..... Taxon
Biosciences .... Taxus
Cardium (formerly Cardium Therapeutics) ... Taylor
Devices .....Taysha Gene Therapies .... TCR² Therapeutics ..... TDA
Research .... Tealium ..... TearScience
... TearSolutions .... Tech-X ....
Techniscan Medical Systems
... Technology
and Devices Int'l ... TechTol Imaging ... Tectus ..... TELA
Bio .....
Telecardia ...
TeleContinuity ... Telefactor ..... Telemedicine
Up Close operates as DxUpClose ...... Telik ... Tempest
Therapeutics ..... Templex
Technology... Tempus ..... Tenax Therapeutics .... Tenaya
Therapeutics ..... Tendril
...
Tendyne
Holdings ..... Tensha Therapeutics ...
Tepha
... TeraDiode .... TeraDiscoveries (now Cloud
Pharma) ....
Terapio ... TeraStor ...
Terrabon ...
Terrajoule ... TerraMetrics ... Terumo BCT .... Terus
Technologies .... TESARO ....
TeselaGen
Biotechnology .... Tessera
Technologies ... Tethys BioScience .... Tetra
Discovery
Partners .... Tetragenetics
... TetraLogic Pharmaceuticals ...
Tetraphase
Pharmaceuticals ... TetraVue ... Tezzaron
Semiconductor .... TFF Pharmaceuticals .... TGS Knee Innovations
... TG Therapeutics .... Thar Pharma .... Thalchemy ..... The
ExOne .... The Medicines ..... Therabron Therapeutics ..... Theraclone
Sciences ... Theradaptive ... Theragenics
.... Therametric Technologies ... Theranos
....
Therion
Biologics ... Thermacore ... Thermage
...
Thermal Gradiant .... Thermal Spray Technologies
....
ThermalTherapeutic Systems
... Thermedical ...
ThermoAura ....
ThermoCeramiX .... ThermoGenesis .... Thermon ... TherOx ....
Thesan
Pharmaceuticals .... Theseus...
Thetis Pharmaceuticals ...
ThingMagic... Third Wave Technologies .. Thoratech
Tech
... Thorley Industries .... ThreeRivers 3D ..... Threshold
Pharmaceuticals .... Thrive Earlier Detection .....
ThromboVision .... Thyritope Biosciences
.... Tiax ... Tibbetts Industries
... Tibion ..... Tiburio
Therapeutics ..... Tilera ... Tillges
Technologies ... Tilos Therapeutics .... Tioma Therapeutics .....
TissueGene ..... TissueLink
... Tissue Regeneration Systems .... Titan
Pharmaceuticals .... Titan Spine ..... TJ Technologies .... TLC
Precision Wafer
... Tmunity Therapeutics .... Tobira Therapeutics ....
Tocagen
...
Tokai Pharmaceuticals .... Tolerx .... TomoTherapy
... Tone Tree ..... Topia Technology .... TopicalRemedy ....
Topokine Therapeutics
.... Torax
Medical ... Torque Therapeutics ..... Total Immersion
...
TotipotentRx .... Totus Solutions .... Toyon Research ..... TP
Therapeutics ..... Trace
Genomics ..... Tracon
Pharmaceuticals
... Tranquis
Therapeutics .... TranS1
.... TransAstra .... Transatomic Power .... Transcend Medical
...Transcept Pharmaceuticals .... TransCorp
..... Transcriptic ..... TransEnterix ... Transgenomic
... Translattice ..... TransMedics
... Transmeta ... TransMolecular
... Transphorm .....
TransTech
.... TransTech Pharma (now vTv Therapeutics) ... Transzyme
Transzyme Pharma ... Travecta Therapeutics .... Traverse
Biosciences ... Traycer
Diagnostic Systems ..... Trefoil Thera .... Trellis
Bioscience
... Trellis Earth Products ... Trethera
.... Trevena
... Trevi Therapeutics ..... Trex Enterprises ... Triad
Semiconductor .... Tri Alpha
Energy ..... Triangle
BioSystems .... Tribogenics
....
Tribologix
.... Trice Medical .... Trice
Orthopedics .... Tricida ..... Trident Systems ... Trilumina ....
Trimble Navigation
.... Trimeris
... Triplet Therapeutics .... Triquint Semiconductor ...
Triton Systems ... >Triumvira
Immunologics ... Trius Therapeutics ...
TriVascular Technologies .... Trovagene ..... Trubion
Pharmaceuticals ... Trucode
Gene Repair .... Tru-D SmartUVC ..... True Bearing Diagnostics ....
True Diagnostics
....
True Health Diagnostics
.... True North Therapeutics .... Truestone ..... TruTouch Technologies
..... Try Eco ..... Tryton
Medical
... TScan Therapeutics ..... Tularik .... Turtle Mountain
Communications .... TVA Medical
... Tvardi Therapeutics .... Twelve .... Twentyeight-Seven
Therapeutics ...... Twin Star Medical ... Twist
Bioscience
..... TwoXAR ..... Tyme Technologies .... TypeZero Technologies
....Tyra Biosciences .... Tyrosine Pharmaceuticals .... Tyrx
uBiome .... UCAN
... UES
... Ulthera .... UltraCell ... Ultragenyx
....
Ultralife Batteries
...
Ultramet... Ultradian
Diagnostics ..... Ultraviolet Sciences ... Unbounded Robotics
.... Unchained Labs .... UNIAX
... Unica
... Unidym ... UniEnergy Technologies ..... Unified
Nexsys
.... Unilife ..... Uni-Pixel .... Uniqure
.... United
Devices ... United
Therapeutics
... United Therapies ..... Unity Biotechnology .... Universal
Cells ...... Universal
Display ... Universal
Robots ..... Universal
Technical Resources .... Universal
Technology .... Unleash Immuno
Oncolytics ..... Unum Therapeutics .... Unwired
Nation ... Uptake Medical
... UQM Technologies ... Urbix Resources ....
Urigen
Pharmaceuticals
.... UroGene Pharma ..... US
Nanocorp ... Uroplasty ..... Ursa Major Technologies .... US
Bioscience ..... US
Silicones ... UTC Power .... Utilidata ... Utron
.....
UVision360
Vaccinex .....
Vaccinogen .... Vader Systems ..... VakSea ....
Vala Sciences
....Valencell ... Valence Technology .... Validity
Sensors
... Valmont Industries .... Valulytics .... Vanda
Pharmaceuticals
... Vanguard Space Technologies ..... Vapogenix ..... Variant
Pharmaceuticals ..... Vascudyne ..... Vascular
Biogenics (also VBL Therapeutics) ..... Vascular
Designs ... Vascular Genesis ..... Vascular Pathways
...
Vascular Pharmaceuticals ....
Vascular Solutions .....
Vasculox .... VasoGenix
Pharmaceuticals ... Vasoptic Medical ..... Vast Therapeutics
.... Vativ
Technologies ... Vaxart ... Vaxcyte
(formerly Sutrovax) .... Vaxess
Technologies ....
VaxGen
... VaxNewMo ..... VaxInnate ... VBI
Vaccines .... vCalc
.... Vecna Tech ... Vectorlogics ....
Vedanta Biosciences
.... Vedere Bio ... Veeva Systems .... Veezyon
... VeinAid ... Velano Vascular .... Velicept
Therapeutic
..... Velocimed ...
Velomedix
... VelosBio ..... VenatoRx Pharmaceuticals ..... Venaxis
..... Vendormate
....
Veniti ... Vensun
Pharmaceuticals ....
VentiRx
...
Ventria Bioscience
... Ventrix ..... Ventrus
Biosciences ... Ventus Therapeutics .....
Veracode
... Veracyte (now AlloVir) ... Veralox
Therapeutics .... Veran Medical Technologies
..... Verastem
... VeraSun Energy
... VerAvanti .... Verax
Biomedical ... Verdezyne ... Vergent Bioscience .....
VerinataHealth ...
Verenium ... Vericel (formerly Aastrom Bio) .... Verifica-BG
... Veritas Genetics .....
Vermillion .... Vermont
Composites ...Veros Systems ... Verrica Pharmaceuticals .... Versar
.... Versartis ... Versatope ..... Verseau
Therapeutics ... Vesigen Therapeutics .... Vestagen Technical
Textiles .... Vestaron .... VerteCore ..... VerteraSpine ..... Vertex
Pharmaceuticals ... VeruTEK Technologies ... Verve
Therapeutic .... Vesper
Medical
..... Vextec
... VGBioCogCubed .... V-Glass .... VGo
Communications ... VGX Pharmaceuticals ..... ViaCell
... ViaCyte
.... Viacor
.... Viamet Pharmaceuticals
... ViaSat
... Via Separations .... Vical . .. Vicarious .... Vicus Technologies
.... Vidacare VIDA Diagnostics ..... ... View .....
Vigene Biosciences .... Viking
Therapeutics .... Vion
Pharmaceuticals
... ViraCor Laboratories ... Viracta Therapeutics ..... Viral
Genetics ....
Vir Biotech .... Virdante Pharmaceuticals
...
Virdia
.... Virent Energy Systems ... Viresco Energy
... Virna
Therapeutics .... Virobay .... ViroPharma . .. ViroXis ...
Virtify ... Virtualitics .... VirtualScopics
.... Virtusa
... Viscardia ..... VisEn Medical ... VisiGen
Biotechnologies
... VisionGate ..... VisionQuest ..... Vision-Sciences
... Vistagen
Therapeutics ... Vistec
Lithography ... Visterra ...
Visualase .... Vitae Pharmaceuticals ..... VitalMedix
... Vital Therapies ...... Vital Vio .... VitaPath Genetics
... Vitriflex .... Vium ..... Vivex Biomedical
.... Vividion Therapeutics ..... Vivisimo .... Vixar
... Vixel ... Vixiar Medical ..... Vizgen ... Vizzario ....
Vlingo
... VLST ..... VMware ... Voci Technologies .... Volcano ....
Voltron
Therapeutics .... VoltServer ... VORAGO Technologies
(previously Silicon
Space Technology) ..... Vorbeck Materials
... Vor BioPharma ..... Vortex Biosciences ..... Vortex
Medical
... Voxel
.. voxeljet ..... Voyager Therapeutics
.... Vtesse ....
VT
Silicon
.... vTv Therapeutics (formerly TransTech Pharma) ..... VUV Analytics
.... Vuzix .... Vyriad .... Vyrx
Pharmaceuticals ..... VytronUS
WaferGen
Biosystems ...
Wakonda Technologies ... Walden Biosciences .... Walker
Magnetics Group ...
Waste2Watergy
.... Waveband
..... Wave Computing ..... Waveguide ..... WaveRx ... Weinberg Medical
Physics .... WellStat
Therapeutics .... Werewolf Therapeutics ..... Whole Biome ..... Whole
Trees
.....
WiBotic .... Wicab ..... Wickr ... WildcatDiscovery ....
Wiliot .....
Willow Garage
... Wildcat ... Wilder Systems .... Wilocity
.... Wilson.... Greatbatch
.. Wilson Tool International .... Wilson Wolf Manufacturing
...
WiMax.com ...
Windlift ... Windtree
Therapeutics ..... WinSanTor .... Wintegra ... WISErg .... Wizbe
Innovations ...
WMR
Biomedical (now Arsenal Medical) ... Wolf Technical
Services ... WoundZoom .... Woven Orthopedic Technologies
....
Wright Materials Research
... Wright Therapy Products ..... W Solar
Group
X4 Pharmaceuticals .....
Xanofi ... Xanthus
Pharmaceuticals
... XBiotech USA ..... X-Biotix Therapeutics .... X-Body
Biosciences
... Xcede Technologies ..... XCELL BIOLOGIX .....
Xcell Biosciences
....
Xcellerex ... XChanger
Companies .... X-COR Therapeutics .... Xencor .... X-energy .....
Xenetic Biosciences ....
Xenex
Disinfection Services .... Xenex
Healthcare Services ... XenoGen Biosystems .... Xenomics
... Xenoport ... Xeris
Pharmaceuticals ... Xetrios Therapeutics .... XF
Technologies .... xG Technology .... Xidex ... Xilio Therapeutics
(formerly Akrevia Thera) .... Xitronix
... XL
Hybrids ... Xlumena .... Xoc Pharmaceuticals ..... Xollai ...
Xolve
(formerly
Graphene Solutions)
... Xoma
... XProSciences (now Icagen) ..... X-Ray Optical .... X-Spine
.... XSunX
...
Xtalic .. Xtant Medical
Holdings ..... Xtent ...Xtreme Power
... XTuit Pharmaceuticals ....
Xunlight .... XyloCor Therapeutics .... Xynomic
Pharma
Yan Engines ... Yardney Technical Products .... Y-Carbon ... Yield 10 .... Yulex .... Yumanity Therapeutics .... Yurie